EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle

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In mice, certain proteins show a highly confined expression in specific muscle groups. Also, resting and exercise/contraction-induced phosphorylation responses are higher in rat skeletal muscle with low mitochondrial content compared to muscles with high mitochondrial content, possibly related to differential reactive oxygen species (ROS)-scavenging ability or resting glycogen content. To evaluate these parameters in humans, biopsies from soleus, gastrocnemius and vastus lateralis muscles were taken before and after a 45 min inclined (15%) walking exercise bout at 69% VO2(max) aimed at simultaneously activating soleus and gastrocnemius in a comparable dynamic work-pattern. Hexokinase II and GLUT4 were 46-59% and 26-38% higher (p
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind7
Udgave nummer2
Sider (fra-til)e31054
Antal sider8
ISSN1932-6203
DOI
StatusUdgivet - 8 feb. 2012

Bibliografisk note

CURIS 2012 5200 069

ID: 38565955