Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a health claim pursuant to Article 13.1 of Regulation (EC) No 1924/2006 in the framework of further assessment related to alpha-cyclodextrin and reduction of post-prandial glycaemic responses. The food constituent that is the subject of the claim, alpha-cyclodextrin, is sufficiently characterised. The claimed effect, reduction of post-prandial glycaemic responses (as long as post-prandial insulinaemic responses are not disproportionally increased), may be a beneficial physiological effect. The proposed target population is individuals who wish to reduce their post-prandial glycaemic responses. In weighing the evidence, the Panel took into account that two intervention studies showed a significant effect of alpha-cyclodextrin added to starch on post-prandial glycaemic responses without disproportionally increasing post prandial insulinaemic responses, that one study on alpha-cyclodextrin added to sucrose did not show an effect on post-prandial glycaemic responses, and that there is some evidence in support of a plausible mechanism by which alpha-cyclodextrin could exert the claimed effect. On the basis of the data presented, the Panel concludes that a cause and effect relationship has been established between the consumption of alpha-cyclodextrin with starch containing meals and reduction of post-prandial glycaemic responses. The Panel considers that in order to obtain the claimed effect, at least 5 g of alpha-cyclodextrin per 50 g of starch should be consumed. The target population is adults who wish to reduce their post-prandial glycaemic responses.