Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. / Magkos, Faidon; Fraterrigo, Gemma; Yoshino, Jun; Luecking, Courtney; Kirbach, Kyleigh; Kelly, Shannon C; de Las Fuentes, Lisa; He, Songbing; Okunade, Adewole L; Patterson, Bruce W; Klein, Samuel.

I: Cell Metabolism, Bind 23, Nr. 4, 2016, s. 591-601.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Magkos, F, Fraterrigo, G, Yoshino, J, Luecking, C, Kirbach, K, Kelly, SC, de Las Fuentes, L, He, S, Okunade, AL, Patterson, BW & Klein, S 2016, 'Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity', Cell Metabolism, bind 23, nr. 4, s. 591-601. https://doi.org/10.1016/j.cmet.2016.02.005

APA

Magkos, F., Fraterrigo, G., Yoshino, J., Luecking, C., Kirbach, K., Kelly, S. C., de Las Fuentes, L., He, S., Okunade, A. L., Patterson, B. W., & Klein, S. (2016). Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. Cell Metabolism, 23(4), 591-601. https://doi.org/10.1016/j.cmet.2016.02.005

Vancouver

Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC o.a. Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. Cell Metabolism. 2016;23(4):591-601. https://doi.org/10.1016/j.cmet.2016.02.005

Author

Magkos, Faidon ; Fraterrigo, Gemma ; Yoshino, Jun ; Luecking, Courtney ; Kirbach, Kyleigh ; Kelly, Shannon C ; de Las Fuentes, Lisa ; He, Songbing ; Okunade, Adewole L ; Patterson, Bruce W ; Klein, Samuel. / Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. I: Cell Metabolism. 2016 ; Bind 23, Nr. 4. s. 591-601.

Bibtex

@article{dd9d8e9f60bd4f3e9b5525bcc184768c,
title = "Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity",
abstract = "Although 5%-10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β cell function, without a concomitant change in systemic or subcutaneous adipose tissue markers of inflammation. Additional weight loss further improved β cell function and insulin sensitivity in muscle and caused stepwise changes in adipose tissue mass, intrahepatic triglyceride content, and adipose tissue expression of genes involved in cholesterol flux, lipid synthesis, extracellular matrix remodeling, and oxidative stress. These results demonstrate that moderate 5% weight loss improves metabolic function in multiple organs simultaneously, and progressive weight loss causes dose-dependent alterations in key adipose tissue biological pathways. ",
keywords = "Adipose Tissue/metabolism, Adult, Female, Humans, Insulin/metabolism, Insulin Resistance, Insulin-Secreting Cells/metabolism, Liver/metabolism, Male, Middle Aged, Muscles/metabolism, Obesity/metabolism, Weight Loss",
author = "Faidon Magkos and Gemma Fraterrigo and Jun Yoshino and Courtney Luecking and Kyleigh Kirbach and Kelly, {Shannon C} and {de Las Fuentes}, Lisa and Songbing He and Okunade, {Adewole L} and Patterson, {Bruce W} and Samuel Klein",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
doi = "10.1016/j.cmet.2016.02.005",
language = "English",
volume = "23",
pages = "591--601",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity

AU - Magkos, Faidon

AU - Fraterrigo, Gemma

AU - Yoshino, Jun

AU - Luecking, Courtney

AU - Kirbach, Kyleigh

AU - Kelly, Shannon C

AU - de Las Fuentes, Lisa

AU - He, Songbing

AU - Okunade, Adewole L

AU - Patterson, Bruce W

AU - Klein, Samuel

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016

Y1 - 2016

N2 - Although 5%-10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β cell function, without a concomitant change in systemic or subcutaneous adipose tissue markers of inflammation. Additional weight loss further improved β cell function and insulin sensitivity in muscle and caused stepwise changes in adipose tissue mass, intrahepatic triglyceride content, and adipose tissue expression of genes involved in cholesterol flux, lipid synthesis, extracellular matrix remodeling, and oxidative stress. These results demonstrate that moderate 5% weight loss improves metabolic function in multiple organs simultaneously, and progressive weight loss causes dose-dependent alterations in key adipose tissue biological pathways.

AB - Although 5%-10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β cell function, without a concomitant change in systemic or subcutaneous adipose tissue markers of inflammation. Additional weight loss further improved β cell function and insulin sensitivity in muscle and caused stepwise changes in adipose tissue mass, intrahepatic triglyceride content, and adipose tissue expression of genes involved in cholesterol flux, lipid synthesis, extracellular matrix remodeling, and oxidative stress. These results demonstrate that moderate 5% weight loss improves metabolic function in multiple organs simultaneously, and progressive weight loss causes dose-dependent alterations in key adipose tissue biological pathways.

KW - Adipose Tissue/metabolism

KW - Adult

KW - Female

KW - Humans

KW - Insulin/metabolism

KW - Insulin Resistance

KW - Insulin-Secreting Cells/metabolism

KW - Liver/metabolism

KW - Male

KW - Middle Aged

KW - Muscles/metabolism

KW - Obesity/metabolism

KW - Weight Loss

U2 - 10.1016/j.cmet.2016.02.005

DO - 10.1016/j.cmet.2016.02.005

M3 - Journal article

C2 - 26916363

VL - 23

SP - 591

EP - 601

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 4

ER -

ID: 289960744