Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity

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Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity. / Magkos, Faidon; Sullivan, Shelby; Fitch, Mark; Smith, Gordon; Fabbrini, Elisa; Mittendorfer, Bettina; Hellerstein, Marc; Klein, Samuel.

I: Obesity, Bind 25, Nr. Suppl 2, 2017, s. S81-S86.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Magkos, F, Sullivan, S, Fitch, M, Smith, G, Fabbrini, E, Mittendorfer, B, Hellerstein, M & Klein, S 2017, 'Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity', Obesity, bind 25, nr. Suppl 2, s. S81-S86. https://doi.org/10.1002/oby.21983

APA

Magkos, F., Sullivan, S., Fitch, M., Smith, G., Fabbrini, E., Mittendorfer, B., Hellerstein, M., & Klein, S. (2017). Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity. Obesity, 25(Suppl 2), S81-S86. https://doi.org/10.1002/oby.21983

Vancouver

Magkos F, Sullivan S, Fitch M, Smith G, Fabbrini E, Mittendorfer B o.a. Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity. Obesity. 2017;25(Suppl 2):S81-S86. https://doi.org/10.1002/oby.21983

Author

Magkos, Faidon ; Sullivan, Shelby ; Fitch, Mark ; Smith, Gordon ; Fabbrini, Elisa ; Mittendorfer, Bettina ; Hellerstein, Marc ; Klein, Samuel. / Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity. I: Obesity. 2017 ; Bind 25, Nr. Suppl 2. s. S81-S86.

Bibtex

@article{5d57ac3f1829417e8945dc1495c428c6,
title = "Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity",
abstract = "Objective: To evaluate the effects of diet-induced changes in energy balance and body weight on in vivo colonocyte fractional proliferation rates (FPR) in people with obesity.Methods: In vivo colonocyte FPR was assessed in 31 men and women with obesity (BMI: 35.4 ± 4.0 kg/m2 , age: 52.6 ± 8.9 years) before and after diet-induced weight loss, weight gain, or weight maintenance. Subjects ingested aliquots of 2H2O (heavy water) daily for 4 to 7 days, followed by flexible sigmoidoscopy with colon biopsies to assess the incorporation of 2 H into the DNA of dividing colonocytes.Results: Colonocyte FPR averaged 12.7% ± 3.8% per day and correlated directly with intra-abdominal adipose tissue (IAAT) volume (r = 0.364, P = 0.044). Colonocyte FPR decreased in the weight loss group, did not change in the weight maintenance group, and increased in the weight gain group. The change in colonocyte FPR correlated directly with the percent change in body weight (r = 0.409, P = 0.028) and IAAT volume (r = 0.598, P = 0.001).Conclusions: A high-calorie diet and weight gain increase, whereas a low-calorie diet and weight loss decrease, in vivo colonocyte proliferation rate in people with obesity. These results suggest that changes in energy balance influence the risk of developing colon cancer in people with obesity by regulating colonic mucosal growth rates.",
keywords = "Biopsy, Body Composition, Body Weight, Cell Proliferation, Colon/cytology, Colonic Neoplasms/etiology, Female, Humans, Male, Middle Aged, Obesity, Abdominal/complications, Risk, Weight Gain, Weight Loss",
author = "Faidon Magkos and Shelby Sullivan and Mark Fitch and Gordon Smith and Elisa Fabbrini and Bettina Mittendorfer and Marc Hellerstein and Samuel Klein",
note = "{\textcopyright} 2017 The Obesity Society.",
year = "2017",
doi = "10.1002/oby.21983",
language = "English",
volume = "25",
pages = "S81--S86",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "Suppl 2",

}

RIS

TY - JOUR

T1 - Effect of weight gain and weight loss on in vivo colonocyte proliferation rate in people with obesity

AU - Magkos, Faidon

AU - Sullivan, Shelby

AU - Fitch, Mark

AU - Smith, Gordon

AU - Fabbrini, Elisa

AU - Mittendorfer, Bettina

AU - Hellerstein, Marc

AU - Klein, Samuel

N1 - © 2017 The Obesity Society.

PY - 2017

Y1 - 2017

N2 - Objective: To evaluate the effects of diet-induced changes in energy balance and body weight on in vivo colonocyte fractional proliferation rates (FPR) in people with obesity.Methods: In vivo colonocyte FPR was assessed in 31 men and women with obesity (BMI: 35.4 ± 4.0 kg/m2 , age: 52.6 ± 8.9 years) before and after diet-induced weight loss, weight gain, or weight maintenance. Subjects ingested aliquots of 2H2O (heavy water) daily for 4 to 7 days, followed by flexible sigmoidoscopy with colon biopsies to assess the incorporation of 2 H into the DNA of dividing colonocytes.Results: Colonocyte FPR averaged 12.7% ± 3.8% per day and correlated directly with intra-abdominal adipose tissue (IAAT) volume (r = 0.364, P = 0.044). Colonocyte FPR decreased in the weight loss group, did not change in the weight maintenance group, and increased in the weight gain group. The change in colonocyte FPR correlated directly with the percent change in body weight (r = 0.409, P = 0.028) and IAAT volume (r = 0.598, P = 0.001).Conclusions: A high-calorie diet and weight gain increase, whereas a low-calorie diet and weight loss decrease, in vivo colonocyte proliferation rate in people with obesity. These results suggest that changes in energy balance influence the risk of developing colon cancer in people with obesity by regulating colonic mucosal growth rates.

AB - Objective: To evaluate the effects of diet-induced changes in energy balance and body weight on in vivo colonocyte fractional proliferation rates (FPR) in people with obesity.Methods: In vivo colonocyte FPR was assessed in 31 men and women with obesity (BMI: 35.4 ± 4.0 kg/m2 , age: 52.6 ± 8.9 years) before and after diet-induced weight loss, weight gain, or weight maintenance. Subjects ingested aliquots of 2H2O (heavy water) daily for 4 to 7 days, followed by flexible sigmoidoscopy with colon biopsies to assess the incorporation of 2 H into the DNA of dividing colonocytes.Results: Colonocyte FPR averaged 12.7% ± 3.8% per day and correlated directly with intra-abdominal adipose tissue (IAAT) volume (r = 0.364, P = 0.044). Colonocyte FPR decreased in the weight loss group, did not change in the weight maintenance group, and increased in the weight gain group. The change in colonocyte FPR correlated directly with the percent change in body weight (r = 0.409, P = 0.028) and IAAT volume (r = 0.598, P = 0.001).Conclusions: A high-calorie diet and weight gain increase, whereas a low-calorie diet and weight loss decrease, in vivo colonocyte proliferation rate in people with obesity. These results suggest that changes in energy balance influence the risk of developing colon cancer in people with obesity by regulating colonic mucosal growth rates.

KW - Biopsy

KW - Body Composition

KW - Body Weight

KW - Cell Proliferation

KW - Colon/cytology

KW - Colonic Neoplasms/etiology

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Obesity, Abdominal/complications

KW - Risk

KW - Weight Gain

KW - Weight Loss

U2 - 10.1002/oby.21983

DO - 10.1002/oby.21983

M3 - Journal article

C2 - 29086514

VL - 25

SP - S81-S86

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - Suppl 2

ER -

ID: 210874222