TY - JOUR

T1 - Effect of increased intake of skimmed milk, casein, whey or water on body composition and leptin in overweight adolescents

T2 - a randomized trial

AU - Larnkjær, Anni

AU - Arnberg, Karina

AU - Michaelsen, Kim F.

AU - Jensen, Signe Marie

AU - Mølgaard, Christian

N1 - CURIS 2015 NEXS 060

PY - 2015

Y1 - 2015

N2 - BACKGROUNDS: Dairy proteins may support muscle protein synthesis and improve satiety in adults. However, there are limited studies using exact measures of body composition, especially in adolescents.OBJECTIVES: This study investigates the effect of milk proteins and water on body composition and leptin in overweight adolescents.METHODS: Subjects (n = 193) aged 12-15 years were randomized to drink 1 L d(-1) of skimmed milk, whey, casein (all milk-based drinks 35 g protein L(-1) ) or water for 12 weeks. Twenty participants dropped out. A pre-test control group of 32 adolescents was examined 12 weeks before start of intervention. Outcomes included leptin and dual-energy X-ray absorptiometry scanning. The effects of the milk-based drinks on body composition and leptin were compared with baseline, pre-test control and water.RESULTS: Lean mass index (LMI) increased compared to baseline (all 95% confidence intervals 0.05-0.50 kg m(-2) , all P ≤ 0.009) and the pre-test control group (0.044-0.247 kg m(-2) , P ≤ 0.002) for all four test drinks. Fat mass index (FMI) increased only for milk-based drink groups compared with baseline (0.15-0.67 kg m(-2) , P < 0.001) and also compared with water (0.029-0.255 kg m(-2) , P ≤ 0.011). For pre-test control, there was no change in FMI or LMI. Leptin increased in the casein (1.016-3.246 ng mL(-1) , P < 0.001; 0.952-3.294 ng mL(-1) , P < 0.001) and whey groups (0.135-2.273 ng mL(-1) , P = 0.027; 0.069-2.322, P = 0.038) compared with water and pre-test control group, respectively.CONCLUSIONS: Although milk proteins increased LMI in overweight adolescents, there was a concurrent increase in FMI and leptin, whereas water only resulted in increased LMI. Thus, increased water intake may be beneficial for body composition in overweight adolescents.

AB - BACKGROUNDS: Dairy proteins may support muscle protein synthesis and improve satiety in adults. However, there are limited studies using exact measures of body composition, especially in adolescents.OBJECTIVES: This study investigates the effect of milk proteins and water on body composition and leptin in overweight adolescents.METHODS: Subjects (n = 193) aged 12-15 years were randomized to drink 1 L d(-1) of skimmed milk, whey, casein (all milk-based drinks 35 g protein L(-1) ) or water for 12 weeks. Twenty participants dropped out. A pre-test control group of 32 adolescents was examined 12 weeks before start of intervention. Outcomes included leptin and dual-energy X-ray absorptiometry scanning. The effects of the milk-based drinks on body composition and leptin were compared with baseline, pre-test control and water.RESULTS: Lean mass index (LMI) increased compared to baseline (all 95% confidence intervals 0.05-0.50 kg m(-2) , all P ≤ 0.009) and the pre-test control group (0.044-0.247 kg m(-2) , P ≤ 0.002) for all four test drinks. Fat mass index (FMI) increased only for milk-based drink groups compared with baseline (0.15-0.67 kg m(-2) , P < 0.001) and also compared with water (0.029-0.255 kg m(-2) , P ≤ 0.011). For pre-test control, there was no change in FMI or LMI. Leptin increased in the casein (1.016-3.246 ng mL(-1) , P < 0.001; 0.952-3.294 ng mL(-1) , P < 0.001) and whey groups (0.135-2.273 ng mL(-1) , P = 0.027; 0.069-2.322, P = 0.038) compared with water and pre-test control group, respectively.CONCLUSIONS: Although milk proteins increased LMI in overweight adolescents, there was a concurrent increase in FMI and leptin, whereas water only resulted in increased LMI. Thus, increased water intake may be beneficial for body composition in overweight adolescents.

U2 - 10.1111/ijpo.12007

DO - 10.1111/ijpo.12007

M3 - Journal article

C2 - 25612082

VL - 10

SP - 461

EP - 467

JO - Pediatric obesity

JF - Pediatric obesity

SN - 2047-6302

IS - 6

ER -