DOPA, norepinephrine, and dopamine in rat tissues: no effect of sympathectomy on muscle DOPA

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Standard

DOPA, norepinephrine, and dopamine in rat tissues : no effect of sympathectomy on muscle DOPA. / Eldrup, E; Richter, Erik A.; Christensen, N J.

I: American Journal of Physiology (Consolidated), Bind 256, Nr. 2 Pt 1, 1989, s. E284-E287.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Eldrup, E, Richter, EA & Christensen, NJ 1989, 'DOPA, norepinephrine, and dopamine in rat tissues: no effect of sympathectomy on muscle DOPA', American Journal of Physiology (Consolidated), bind 256, nr. 2 Pt 1, s. E284-E287.

APA

Eldrup, E., Richter, E. A., & Christensen, N. J. (1989). DOPA, norepinephrine, and dopamine in rat tissues: no effect of sympathectomy on muscle DOPA. American Journal of Physiology (Consolidated), 256(2 Pt 1), E284-E287.

Vancouver

Eldrup E, Richter EA, Christensen NJ. DOPA, norepinephrine, and dopamine in rat tissues: no effect of sympathectomy on muscle DOPA. American Journal of Physiology (Consolidated). 1989;256(2 Pt 1):E284-E287.

Author

Eldrup, E ; Richter, Erik A. ; Christensen, N J. / DOPA, norepinephrine, and dopamine in rat tissues : no effect of sympathectomy on muscle DOPA. I: American Journal of Physiology (Consolidated). 1989 ; Bind 256, Nr. 2 Pt 1. s. E284-E287.

Bibtex

@article{5fbb7e46b1e6452390e80b739d5aae9f,
title = "DOPA, norepinephrine, and dopamine in rat tissues: no effect of sympathectomy on muscle DOPA",
abstract = "We studied the effect of unilateral sympathectomy on rat quadriceps and gastrocnemius muscle concentrations of endogenous dihydroxyphenylalanine (DOPA), dopamine (DA), and norepinephrine (NE) and assessed the relationships between these catecholamines in several rat tissues. Catecholamines were measured by reverse-phase high-performance liquid chromatography with electrochemical detection. Sympathectomy decreased NE and DA concentrations of muscles to approximately 10% of control values, whereas the DOPA concentration tended to increase. Relatively high concentrations of DOPA were found in the gastrointestinal tract, kidney, and spleen. No correlations were obtained between the tissue concentration of DOPA and NE. A DA-to-NE ratio approximately 1% was observed in liver, muscle, pancreas, spleen, and heart, whereas we found exponentially increasing DA values with increasing NE concentration in tissues obtained from stomach, small and large intestine, kidney, and lung. In conclusion, endogenous DOPA in muscle tissue is not located in sympathetic nerve terminals but probably in muscle cells. DA concentrations in the gastrointestinal tract and in the kidneys were greater than could be ascribed to its role as a precursor in the biosynthesis of NE.",
keywords = "Animals, Dihydroxyphenylalanine, Dopamine, Ganglionectomy, Male, Muscles, Norepinephrine, Organ Specificity, Rats, Rats, Inbred Strains, Reference Values",
author = "E Eldrup and Richter, {Erik A.} and Christensen, {N J}",
year = "1989",
language = "English",
volume = "256",
pages = "E284--E287",
journal = "American Journal of Physiology (Consolidated)",
issn = "0002-9513",
publisher = "American Physiological Society",
number = "2 Pt 1",

}

RIS

TY - JOUR

T1 - DOPA, norepinephrine, and dopamine in rat tissues

T2 - no effect of sympathectomy on muscle DOPA

AU - Eldrup, E

AU - Richter, Erik A.

AU - Christensen, N J

PY - 1989

Y1 - 1989

N2 - We studied the effect of unilateral sympathectomy on rat quadriceps and gastrocnemius muscle concentrations of endogenous dihydroxyphenylalanine (DOPA), dopamine (DA), and norepinephrine (NE) and assessed the relationships between these catecholamines in several rat tissues. Catecholamines were measured by reverse-phase high-performance liquid chromatography with electrochemical detection. Sympathectomy decreased NE and DA concentrations of muscles to approximately 10% of control values, whereas the DOPA concentration tended to increase. Relatively high concentrations of DOPA were found in the gastrointestinal tract, kidney, and spleen. No correlations were obtained between the tissue concentration of DOPA and NE. A DA-to-NE ratio approximately 1% was observed in liver, muscle, pancreas, spleen, and heart, whereas we found exponentially increasing DA values with increasing NE concentration in tissues obtained from stomach, small and large intestine, kidney, and lung. In conclusion, endogenous DOPA in muscle tissue is not located in sympathetic nerve terminals but probably in muscle cells. DA concentrations in the gastrointestinal tract and in the kidneys were greater than could be ascribed to its role as a precursor in the biosynthesis of NE.

AB - We studied the effect of unilateral sympathectomy on rat quadriceps and gastrocnemius muscle concentrations of endogenous dihydroxyphenylalanine (DOPA), dopamine (DA), and norepinephrine (NE) and assessed the relationships between these catecholamines in several rat tissues. Catecholamines were measured by reverse-phase high-performance liquid chromatography with electrochemical detection. Sympathectomy decreased NE and DA concentrations of muscles to approximately 10% of control values, whereas the DOPA concentration tended to increase. Relatively high concentrations of DOPA were found in the gastrointestinal tract, kidney, and spleen. No correlations were obtained between the tissue concentration of DOPA and NE. A DA-to-NE ratio approximately 1% was observed in liver, muscle, pancreas, spleen, and heart, whereas we found exponentially increasing DA values with increasing NE concentration in tissues obtained from stomach, small and large intestine, kidney, and lung. In conclusion, endogenous DOPA in muscle tissue is not located in sympathetic nerve terminals but probably in muscle cells. DA concentrations in the gastrointestinal tract and in the kidneys were greater than could be ascribed to its role as a precursor in the biosynthesis of NE.

KW - Animals

KW - Dihydroxyphenylalanine

KW - Dopamine

KW - Ganglionectomy

KW - Male

KW - Muscles

KW - Norepinephrine

KW - Organ Specificity

KW - Rats

KW - Rats, Inbred Strains

KW - Reference Values

M3 - Journal article

C2 - 2493196

VL - 256

SP - E284-E287

JO - American Journal of Physiology (Consolidated)

JF - American Journal of Physiology (Consolidated)

SN - 0002-9513

IS - 2 Pt 1

ER -

ID: 154756995