Dietary regulation of hepatic triacylglycerol content

Dietary regulation of hepatic triacylglycerol content: the role of eucaloric carbohydrate restriction with fat or protein replacement

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Dietary regulation of hepatic triacylglycerol content : the role of eucaloric carbohydrate restriction with fat or protein replacement. / Lundsgaard, Annemarie; Bojsen-Møller, Kirstine Nyvold; Kiens, Bente.

I: Advances in Nutrition, Bind 14, Nr. 6, 2023, s. 1359-1373.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Lundsgaard, A, Bojsen-Møller, KN & Kiens, B 2023, 'Dietary regulation of hepatic triacylglycerol content: the role of eucaloric carbohydrate restriction with fat or protein replacement', Advances in Nutrition, bind 14, nr. 6, s. 1359-1373. https://doi.org/10.1016/j.advnut.2023.08.005

APA

Lundsgaard, A., Bojsen-Møller, K. N., & Kiens, B. (2023). Dietary regulation of hepatic triacylglycerol content: the role of eucaloric carbohydrate restriction with fat or protein replacement. Advances in Nutrition, 14(6), 1359-1373. https://doi.org/10.1016/j.advnut.2023.08.005

Vancouver

Lundsgaard A, Bojsen-Møller KN, Kiens B. Dietary regulation of hepatic triacylglycerol content: the role of eucaloric carbohydrate restriction with fat or protein replacement. Advances in Nutrition. 2023;14(6):1359-1373. https://doi.org/10.1016/j.advnut.2023.08.005

Author

Lundsgaard, Annemarie ; Bojsen-Møller, Kirstine Nyvold ; Kiens, Bente. / Dietary regulation of hepatic triacylglycerol content : the role of eucaloric carbohydrate restriction with fat or protein replacement. I: Advances in Nutrition. 2023 ; Bind 14, Nr. 6. s. 1359-1373.

Bibtex

@article{d0bfa9dd9e4d4a27b19de3fba8df7b8f,

title = "Dietary regulation of hepatic triacylglycerol content: the role of eucaloric carbohydrate restriction with fat or protein replacement",

abstract = "Accumulation of hepatic triacylglycerol (TG) is highly associated with impaired whole-body insulin-glucose homeostasis and dyslipidemia. The summarized findings from human intervention studies investigating the effect of reduced dietary carbohydrate and increased fat intake (and in studies also increased protein) while maintaining energy intake at eucaloric requirements reveal a beneficial effect of carbohydrate reduction on hepatic TG content in obese individuals with steatosis and indices of insulin resistance. Evidence suggests that the reduction of hepatic TG content following reduced intake of carbohydrate and increased fat/protein intake in humans results from regulation of fatty acid (FA) metabolism within the liver, with an increase in hepatic FA oxidation and ketogenesis, together with a concomitant downregulation of FA synthesis from de novo lipogenesis. The adaptations in hepatic metabolism may result from reduced intrahepatic monosaccharide and insulin availability, reduced glycolysis and increased FA availability when carbohydrate intake is reduced.",

keywords = "Faculty of Science, NAFLD, MAFLD, Fatty liver, Diet, Steatosis, Carbohydrate, Fatty acids, Fatty acid oxidation",

author = "Annemarie Lundsgaard and Bojsen-M{\o}ller, {Kirstine Nyvold} and Bente Kiens",

year = "2023",

doi = "10.1016/j.advnut.2023.08.005",

language = "English",

volume = "14",

pages = "1359--1373",

journal = "Advances in Nutrition",

issn = "2161-8313",

publisher = "American Society for Nutrition",

number = "6",

}

RIS

TY - JOUR

T1 - Dietary regulation of hepatic triacylglycerol content

T2 - the role of eucaloric carbohydrate restriction with fat or protein replacement

AU - Lundsgaard, Annemarie

AU - Bojsen-Møller, Kirstine Nyvold

AU - Kiens, Bente

PY - 2023

Y1 - 2023

N2 - Accumulation of hepatic triacylglycerol (TG) is highly associated with impaired whole-body insulin-glucose homeostasis and dyslipidemia. The summarized findings from human intervention studies investigating the effect of reduced dietary carbohydrate and increased fat intake (and in studies also increased protein) while maintaining energy intake at eucaloric requirements reveal a beneficial effect of carbohydrate reduction on hepatic TG content in obese individuals with steatosis and indices of insulin resistance. Evidence suggests that the reduction of hepatic TG content following reduced intake of carbohydrate and increased fat/protein intake in humans results from regulation of fatty acid (FA) metabolism within the liver, with an increase in hepatic FA oxidation and ketogenesis, together with a concomitant downregulation of FA synthesis from de novo lipogenesis. The adaptations in hepatic metabolism may result from reduced intrahepatic monosaccharide and insulin availability, reduced glycolysis and increased FA availability when carbohydrate intake is reduced.

AB - Accumulation of hepatic triacylglycerol (TG) is highly associated with impaired whole-body insulin-glucose homeostasis and dyslipidemia. The summarized findings from human intervention studies investigating the effect of reduced dietary carbohydrate and increased fat intake (and in studies also increased protein) while maintaining energy intake at eucaloric requirements reveal a beneficial effect of carbohydrate reduction on hepatic TG content in obese individuals with steatosis and indices of insulin resistance. Evidence suggests that the reduction of hepatic TG content following reduced intake of carbohydrate and increased fat/protein intake in humans results from regulation of fatty acid (FA) metabolism within the liver, with an increase in hepatic FA oxidation and ketogenesis, together with a concomitant downregulation of FA synthesis from de novo lipogenesis. The adaptations in hepatic metabolism may result from reduced intrahepatic monosaccharide and insulin availability, reduced glycolysis and increased FA availability when carbohydrate intake is reduced.

KW - Faculty of Science

KW - NAFLD

KW - MAFLD

KW - Fatty liver

KW - Diet

KW - Steatosis

KW - Carbohydrate

KW - Fatty acids

KW - Fatty acid oxidation

U2 - 10.1016/j.advnut.2023.08.005

DO - 10.1016/j.advnut.2023.08.005

M3 - Review

C2 - 37591342

VL - 14

SP - 1359

EP - 1373

JO - Advances in Nutrition

JF - Advances in Nutrition

SN - 2161-8313

IS - 6

ER -

ID: 362792178

Institut for Idræt og Ernæring