Determinants and reference values for blood volume and total hemoglobin mass in women and men
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Determinants and reference values for blood volume and total hemoglobin mass in women and men. / Oberholzer, Laura; Montero, David; Robach, Paul; Siebenmann, Christoph; Ryrsøe, Camilla Koch; Bonne, Thomas C.; Breenfeldt Andersen, Andreas; Bejder, Jacob; Karlsen, Trine; Edvardsen, Elisabeth; Rønnestad, Bent R.; Hamarsland, Håvard; Cepeda-Lopez, Ana C.; Rittweger, Jörn; Treff, Gunnar; Ahlgrim, Christoph; Almquist, Nicki Winfield; Hallén, Jostein; Lundby, Carsten.
I: American Journal of Hematology, Bind 99, Nr. 1, 2024, s. 88-98.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Determinants and reference values for blood volume and total hemoglobin mass in women and men
AU - Oberholzer, Laura
AU - Montero, David
AU - Robach, Paul
AU - Siebenmann, Christoph
AU - Ryrsøe, Camilla Koch
AU - Bonne, Thomas C.
AU - Breenfeldt Andersen, Andreas
AU - Bejder, Jacob
AU - Karlsen, Trine
AU - Edvardsen, Elisabeth
AU - Rønnestad, Bent R.
AU - Hamarsland, Håvard
AU - Cepeda-Lopez, Ana C.
AU - Rittweger, Jörn
AU - Treff, Gunnar
AU - Ahlgrim, Christoph
AU - Almquist, Nicki Winfield
AU - Hallén, Jostein
AU - Lundby, Carsten
N1 - Publisher Copyright: © 2023 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.
PY - 2024
Y1 - 2024
N2 - Blood volume (BV) is an important clinical parameter and is usually reported per kg of body mass (BM). When fat mass is elevated, this underestimates BV/BM. One aim was to study if differences in BV/BM related to sex, age, and fitness would decrease if normalized to lean body mass (LBM). The analysis included 263 women and 319 men (age: 10–93 years, body mass index: 14–41 kg/m2) and 107 athletes who underwent assessment of BV and hemoglobin mass (Hbmass), body composition, and cardiorespiratory fitness. BV/BM was 25% lower (70.3 ± 11.3 and 80.3 ± 10.8 mL/kgBM) in women than men, respectively, whereas BV/LBM was 6% higher in women (110.9 ± 12.5 and 105.3 ± 11.2 mL/kgLBM). Hbmass/BM was 34% lower (8.9 ± 1.4 and 11.5 ± 11.2 g/kgBM) in women than in men, respectively, but only 6% lower (14.0 ± 1.5 and 14.9 ± 1.5 g/kgLBM)/LBM. Age did not affect BV. Athlete's BV/BM was 17.2% higher than non-athletes, but decreased to only 2.5% when normalized to LBM. Of the variables analyzed, LBM was the strongest predictor for BV (R2 =.72, p <.001) and Hbmass (R2 =.81, p <.001). These data may only be valid for BV/Hbmass when assessed by CO re-breathing. Hbmass/LBM could be considered a valuable clinical matrix in medical care aiming to normalize blood homeostasis.
AB - Blood volume (BV) is an important clinical parameter and is usually reported per kg of body mass (BM). When fat mass is elevated, this underestimates BV/BM. One aim was to study if differences in BV/BM related to sex, age, and fitness would decrease if normalized to lean body mass (LBM). The analysis included 263 women and 319 men (age: 10–93 years, body mass index: 14–41 kg/m2) and 107 athletes who underwent assessment of BV and hemoglobin mass (Hbmass), body composition, and cardiorespiratory fitness. BV/BM was 25% lower (70.3 ± 11.3 and 80.3 ± 10.8 mL/kgBM) in women than men, respectively, whereas BV/LBM was 6% higher in women (110.9 ± 12.5 and 105.3 ± 11.2 mL/kgLBM). Hbmass/BM was 34% lower (8.9 ± 1.4 and 11.5 ± 11.2 g/kgBM) in women than in men, respectively, but only 6% lower (14.0 ± 1.5 and 14.9 ± 1.5 g/kgLBM)/LBM. Age did not affect BV. Athlete's BV/BM was 17.2% higher than non-athletes, but decreased to only 2.5% when normalized to LBM. Of the variables analyzed, LBM was the strongest predictor for BV (R2 =.72, p <.001) and Hbmass (R2 =.81, p <.001). These data may only be valid for BV/Hbmass when assessed by CO re-breathing. Hbmass/LBM could be considered a valuable clinical matrix in medical care aiming to normalize blood homeostasis.
U2 - 10.1002/ajh.27162
DO - 10.1002/ajh.27162
M3 - Journal article
C2 - 38032792
AN - SCOPUS:85176938455
VL - 99
SP - 88
EP - 98
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 1
ER -
ID: 379034088