Compliance, tolerability and safety of two antioxidant-rich diets: A randomised controlled trial in male smokers
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Compliance, tolerability and safety of two antioxidant-rich diets : A randomised controlled trial in male smokers. / Karlsen, Anette; Svendsen, Mette; Seljeflot, Ingebjørg; Sommernes, Mary Ann; Sexton, Joseph; Brevik, Asgeir; Erlund, Iris; Serafini, Mauro; Bastani, Nasser; Fagertun Remberg, Siv; Borge, Grethe I; Hauger Carlsen, Monica; Kjølsrud Bøhn, Siv; Myhrstad, Mari C; Dragsted, Lars Ove; Duttaroy, Asim K; Haffner, Karin; Laake, Petter; Drevon, Christan A; Arnesen, Harald; Collins, Andrew; Tonstad, Serena; Blomhoff, Rune.
I: British Journal of Nutrition, Bind 106, Nr. 4, 2011, s. 557-571.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Compliance, tolerability and safety of two antioxidant-rich diets
T2 - A randomised controlled trial in male smokers
AU - Karlsen, Anette
AU - Svendsen, Mette
AU - Seljeflot, Ingebjørg
AU - Sommernes, Mary Ann
AU - Sexton, Joseph
AU - Brevik, Asgeir
AU - Erlund, Iris
AU - Serafini, Mauro
AU - Bastani, Nasser
AU - Fagertun Remberg, Siv
AU - Borge, Grethe I
AU - Hauger Carlsen, Monica
AU - Kjølsrud Bøhn, Siv
AU - Myhrstad, Mari C
AU - Dragsted, Lars Ove
AU - Duttaroy, Asim K
AU - Haffner, Karin
AU - Laake, Petter
AU - Drevon, Christan A
AU - Arnesen, Harald
AU - Collins, Andrew
AU - Tonstad, Serena
AU - Blomhoff, Rune
PY - 2011
Y1 - 2011
N2 - It has been suggested that antioxidants attenuate oxidative stress and prevent oxidative stress-related diseases. Paradoxically, randomised controlled trials (RCT) using pharmacological doses of antioxidant supplements have demonstrated harmful effects in smokers. The aim of the present study was to test the compliance, tolerability and safety of two food-based antioxidant-rich diets in smokers. One of the diets provided antioxidants at levels similar to that used in RCT using supplements which previously have generated harmful effects. The present study followed a randomised, parallel-arm dietary intervention for 8 weeks (n 102) in male smokers (age ≥  45 years). Participants were randomised to either antioxidant-rich diet, kiwi fruit or control groups. The antioxidant-rich foods provided about 300 mmol antioxidants/week from a wide range of plant-based food items. The kiwi fruit group consumed three kiwi fruits/d. Compliance to both diets was good. Only mild, undesirable events were reported by a minority of the participants. The safety of both diets was demonstrated as no potentially harmful or pro-oxidative effects were observed. In the antioxidant-rich diet group, the mean intake of antioxidants increased from 30 mmol/d at baseline to 62 mmol/d during the intervention. In conclusion, we have demonstrated that male smokers can comply with two food-based antioxidant-rich diets. Furthermore, the present study is the first to demonstrate the tolerability and safety of dietary antioxidants at levels similar to dosages provided in RCT using supplements. Such diets may be useful in future studies investigating whether dietary antioxidants may reduce oxidative stress and related diseases.
AB - It has been suggested that antioxidants attenuate oxidative stress and prevent oxidative stress-related diseases. Paradoxically, randomised controlled trials (RCT) using pharmacological doses of antioxidant supplements have demonstrated harmful effects in smokers. The aim of the present study was to test the compliance, tolerability and safety of two food-based antioxidant-rich diets in smokers. One of the diets provided antioxidants at levels similar to that used in RCT using supplements which previously have generated harmful effects. The present study followed a randomised, parallel-arm dietary intervention for 8 weeks (n 102) in male smokers (age ≥  45 years). Participants were randomised to either antioxidant-rich diet, kiwi fruit or control groups. The antioxidant-rich foods provided about 300 mmol antioxidants/week from a wide range of plant-based food items. The kiwi fruit group consumed three kiwi fruits/d. Compliance to both diets was good. Only mild, undesirable events were reported by a minority of the participants. The safety of both diets was demonstrated as no potentially harmful or pro-oxidative effects were observed. In the antioxidant-rich diet group, the mean intake of antioxidants increased from 30 mmol/d at baseline to 62 mmol/d during the intervention. In conclusion, we have demonstrated that male smokers can comply with two food-based antioxidant-rich diets. Furthermore, the present study is the first to demonstrate the tolerability and safety of dietary antioxidants at levels similar to dosages provided in RCT using supplements. Such diets may be useful in future studies investigating whether dietary antioxidants may reduce oxidative stress and related diseases.
KW - Antioxidant network
KW - Dietary antioxidants
KW - Oxidative stress
KW - Plasma antioxidants
U2 - 10.1017/S0007114511000353
DO - 10.1017/S0007114511000353
M3 - Journal article
C2 - 21806852
AN - SCOPUS:80053022311
VL - 106
SP - 557
EP - 571
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 4
ER -
ID: 212166253