Compartmentalized muscle redox signals controlling exercise metabolism - Current state, future challenges

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Compartmentalized muscle redox signals controlling exercise metabolism - Current state, future challenges. / Henriquez-Olguin, Carlos; Meneses-Valdes, Roberto; Jensen, Thomas Elbenhardt.

I: Redox Biology, Bind 35, 101473, 2020.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Henriquez-Olguin, C, Meneses-Valdes, R & Jensen, TE 2020, 'Compartmentalized muscle redox signals controlling exercise metabolism - Current state, future challenges', Redox Biology, bind 35, 101473. https://doi.org/10.1016/j.redox.2020.101473

APA

Henriquez-Olguin, C., Meneses-Valdes, R., & Jensen, T. E. (2020). Compartmentalized muscle redox signals controlling exercise metabolism - Current state, future challenges. Redox Biology, 35, [101473]. https://doi.org/10.1016/j.redox.2020.101473

Vancouver

Henriquez-Olguin C, Meneses-Valdes R, Jensen TE. Compartmentalized muscle redox signals controlling exercise metabolism - Current state, future challenges. Redox Biology. 2020;35. 101473. https://doi.org/10.1016/j.redox.2020.101473

Author

Henriquez-Olguin, Carlos ; Meneses-Valdes, Roberto ; Jensen, Thomas Elbenhardt. / Compartmentalized muscle redox signals controlling exercise metabolism - Current state, future challenges. I: Redox Biology. 2020 ; Bind 35.

Bibtex

@article{84bc203a76e947369837b29e32f8d677,
title = "Compartmentalized muscle redox signals controlling exercise metabolism - Current state, future challenges",
abstract = "Exercise imposes cellular stress on contracting skeletal muscle fibers, forcing them to complete molecular adaptations to maintain homeostasis. There is mounting evidence that redox signaling by reactive oxygen species (ROS) is vital for skeletal muscle exercise adaptations across many different exercise modalities. The study of redox signaling is moving towards a growing appreciation that these ROS do not signal in a global unspecific way, but rather elicit their effects in distinct subcellular compartments. This short review will first outline the sources of ROS in exercising skeletal muscle and then discuss some examples of exercise adaptations, which are evidenced to be regulated by compartmentalized redox signaling. We speculate that knowledge of these redox pathways might one day allow targeted manipulation to increase redox-signaling in specific compartments to augment the exercise-hormetic response in health and disease.",
keywords = "Faculty of Science, Reactive oxygen species, Exercise, NADPH oxidase, Mitochondria, Skeletal muscle, Metabolism",
author = "Carlos Henriquez-Olguin and Roberto Meneses-Valdes and Jensen, {Thomas Elbenhardt}",
note = "Copyright {\textcopyright} 2020. Published by Elsevier B.V.",
year = "2020",
doi = "10.1016/j.redox.2020.101473",
language = "English",
volume = "35",
journal = "Redox Biology",
issn = "2213-2317",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Compartmentalized muscle redox signals controlling exercise metabolism - Current state, future challenges

AU - Henriquez-Olguin, Carlos

AU - Meneses-Valdes, Roberto

AU - Jensen, Thomas Elbenhardt

N1 - Copyright © 2020. Published by Elsevier B.V.

PY - 2020

Y1 - 2020

N2 - Exercise imposes cellular stress on contracting skeletal muscle fibers, forcing them to complete molecular adaptations to maintain homeostasis. There is mounting evidence that redox signaling by reactive oxygen species (ROS) is vital for skeletal muscle exercise adaptations across many different exercise modalities. The study of redox signaling is moving towards a growing appreciation that these ROS do not signal in a global unspecific way, but rather elicit their effects in distinct subcellular compartments. This short review will first outline the sources of ROS in exercising skeletal muscle and then discuss some examples of exercise adaptations, which are evidenced to be regulated by compartmentalized redox signaling. We speculate that knowledge of these redox pathways might one day allow targeted manipulation to increase redox-signaling in specific compartments to augment the exercise-hormetic response in health and disease.

AB - Exercise imposes cellular stress on contracting skeletal muscle fibers, forcing them to complete molecular adaptations to maintain homeostasis. There is mounting evidence that redox signaling by reactive oxygen species (ROS) is vital for skeletal muscle exercise adaptations across many different exercise modalities. The study of redox signaling is moving towards a growing appreciation that these ROS do not signal in a global unspecific way, but rather elicit their effects in distinct subcellular compartments. This short review will first outline the sources of ROS in exercising skeletal muscle and then discuss some examples of exercise adaptations, which are evidenced to be regulated by compartmentalized redox signaling. We speculate that knowledge of these redox pathways might one day allow targeted manipulation to increase redox-signaling in specific compartments to augment the exercise-hormetic response in health and disease.

KW - Faculty of Science

KW - Reactive oxygen species

KW - Exercise

KW - NADPH oxidase

KW - Mitochondria

KW - Skeletal muscle

KW - Metabolism

U2 - 10.1016/j.redox.2020.101473

DO - 10.1016/j.redox.2020.101473

M3 - Review

C2 - 32122793

VL - 35

JO - Redox Biology

JF - Redox Biology

SN - 2213-2317

M1 - 101473

ER -

ID: 237513881