TY - JOUR

T1 - Cohort profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO)

AU - Loo, Evelyn Xiu Ling

AU - Soh, Shu-E

AU - Loy, See Ling

AU - Ng, Sharon

AU - Tint, Mya Thway

AU - Chan, Shiao-Yng

AU - Huang, Jonathan Yinhao

AU - Yap, Fabian

AU - Tan, Kok Hian

AU - Chern, Bernard S M

AU - Tan, Heng Hao

AU - Meaney, Michael J

AU - Karnani, Neerja

AU - Godfrey, Keith M

AU - Lee, Yung Seng

AU - Chan, Jerry Kok Yen

AU - Gluckman, Peter D

AU - Chong, Yap-Seng

AU - Shek, Lynette Pei-Chi

AU - Eriksson, Johan G

AU - Chia, Airu

AU - Fogel, Anna Magdalena

AU - Goh, Anne Eng Neo

AU - Chu, Anne Hin Yee

AU - Rifkin-Graboi, Anne

AU - Qiu, Anqi

AU - Lee, Bee Wah

AU - Cheon, Bobby Kyungbeom

AU - Vaz, Candida

AU - Henry, Christiani Jeyakumar

AU - Forde, Ciaran Gerard

AU - Chi, Claudia

AU - Koh, Dawn Xin Ping

AU - Phua, Desiree Y

AU - Loh, Doris Ngiuk Lan

AU - Quah, Elaine Phaik Ling

AU - Tham, Elizabeth Huiwen

AU - Law, Evelyn Chung Ning

AU - Magkos, Faidon

AU - Mueller-Riemenschneider, Falk

AU - Yeo, George Seow Heong

AU - Yong, Hannah Ee Juen

AU - Chen, Helen Yu

AU - Tan, Heng Hao

AU - Pan, Hong

AU - Bever, Hugo P S van

AU - Tan, Hui Min

AU - Aris, Izzuddin Bin Mohd

AU - Tay, Jeannie

AU - Chen, Ling-Wei

AU - S-PRESTO Study Group

N1 - CURIS 2021 NEXS 046

PY - 2021

Y1 - 2021

N2 - The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring. Between February 2015 and October 2017, the S-PRESTO study recruited 1039 Chinese, Malay or Indian (or any combinations thereof) women aged 18-45 years and who intended to get pregnant and deliver in Singapore, resulting in 1032 unique participants and 373 children born in the cohort. The participants were followed up for 3 visits during the preconception phase and censored at 12 months of follow up if pregnancy was not achieved (N = 557 censored). Women who successfully conceived (N = 475) were characterised at gestational weeks 6-8, 11-13, 18-21, 24-26, 27-28 and 34-36. Follow up of their index offspring (N = 373 singletons) is on-going at birth, 1, 3 and 6 weeks, 3, 6, 12, 18, 24 and 36 months and beyond. Women are also being followed up post-delivery. Data is collected via interviewer-administered questionnaires, metabolic imaging (magnetic resonance imaging), standardized anthropometric measurements and collection of diverse specimens, i.e. blood, urine, buccal smear, stool, skin tapes, epithelial swabs at numerous timepoints. S-PRESTO has extensive repeated data collected which include genetic and epigenetic sampling from preconception which is unique in mother-offspring epidemiological cohorts. This enables prospective assessment of a wide array of potential determinants of future health outcomes in women from preconception to post-delivery and in their offspring across the earliest development from embryonic stages into early childhood. In addition, the S-PRESTO study draws from the three major Asian ethnic groups that represent 50% of the global population, increasing the relevance of its findings to global efforts to address non-communicable diseases.

AB - The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring. Between February 2015 and October 2017, the S-PRESTO study recruited 1039 Chinese, Malay or Indian (or any combinations thereof) women aged 18-45 years and who intended to get pregnant and deliver in Singapore, resulting in 1032 unique participants and 373 children born in the cohort. The participants were followed up for 3 visits during the preconception phase and censored at 12 months of follow up if pregnancy was not achieved (N = 557 censored). Women who successfully conceived (N = 475) were characterised at gestational weeks 6-8, 11-13, 18-21, 24-26, 27-28 and 34-36. Follow up of their index offspring (N = 373 singletons) is on-going at birth, 1, 3 and 6 weeks, 3, 6, 12, 18, 24 and 36 months and beyond. Women are also being followed up post-delivery. Data is collected via interviewer-administered questionnaires, metabolic imaging (magnetic resonance imaging), standardized anthropometric measurements and collection of diverse specimens, i.e. blood, urine, buccal smear, stool, skin tapes, epithelial swabs at numerous timepoints. S-PRESTO has extensive repeated data collected which include genetic and epigenetic sampling from preconception which is unique in mother-offspring epidemiological cohorts. This enables prospective assessment of a wide array of potential determinants of future health outcomes in women from preconception to post-delivery and in their offspring across the earliest development from embryonic stages into early childhood. In addition, the S-PRESTO study draws from the three major Asian ethnic groups that represent 50% of the global population, increasing the relevance of its findings to global efforts to address non-communicable diseases.

U2 - 10.1007/s10654-020-00697-2

DO - 10.1007/s10654-020-00697-2

M3 - Journal article

C2 - 33222050

VL - 36

SP - 129

EP - 142

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 1

ER -