Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion

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Standard

Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion. / Hjerpsted, Julie Bousgaard; Dragsted, Lars Ove; Tholstrup, Tine.

I: Journal of Nutrition & Intermediary Metabolism, Bind 3, Nr. 1, 2016, s. 12-17.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hjerpsted, JB, Dragsted, LO & Tholstrup, T 2016, 'Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion', Journal of Nutrition & Intermediary Metabolism, bind 3, nr. 1, s. 12-17. https://doi.org/10.1016/j.jnim.2015.11.002

APA

Hjerpsted, J. B., Dragsted, L. O., & Tholstrup, T. (2016). Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion. Journal of Nutrition & Intermediary Metabolism, 3(1), 12-17. https://doi.org/10.1016/j.jnim.2015.11.002

Vancouver

Hjerpsted JB, Dragsted LO, Tholstrup T. Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion. Journal of Nutrition & Intermediary Metabolism. 2016;3(1):12-17. https://doi.org/10.1016/j.jnim.2015.11.002

Author

Hjerpsted, Julie Bousgaard ; Dragsted, Lars Ove ; Tholstrup, Tine. / Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion. I: Journal of Nutrition & Intermediary Metabolism. 2016 ; Bind 3, Nr. 1. s. 12-17.

Bibtex

@article{beb0c7c8491841258bf0d15769f8af9a,
title = "Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion",
abstract = "Purpose Cheese is a dairy product with high calcium content. It has been suggested that calcium intake may increase fecal excretion of bile acids that would cause a regeneration of bile acids from hepatic cholesterol and thereby result in a lowering of plasma cholesterol concentrations. We aimed to test this hypothesis by assessing bile acid and calcium concentrations in fecal samples from humans after intake of cheese and butter. Methods The study was a randomized, 2 × 6 weeks crossover, dietary intervention study including 23 men and women who replaced part of their habitual dietary fat intake with 13% energy from cheese or butter. Results After 6 weeks of intervention cheese resulted in higher amounts of calcium excreted in feces compared to butter. However, no difference was observed in fecal bile acid output despite lower serum total, LDL and HDL cholesterol concentrations observed with cheese intake. Conclusion We were not able to confirm the hypothesis that calcium from cheese increases the excretion of fecal bile acids. Therefore, the mechanisms responsible for the lowering of cholesterol concentrations with cheese compared to butter intake remains unresolved.",
keywords = "Bile acid, Blood lipids, Cardiovascular, Cholesterol, Dairy",
author = "Hjerpsted, {Julie Bousgaard} and Dragsted, {Lars Ove} and Tine Tholstrup",
note = "CURIS 2016 NEXS 147",
year = "2016",
doi = "10.1016/j.jnim.2015.11.002",
language = "English",
volume = "3",
pages = "12--17",
journal = "Journal of Nutrition & Intermediary Metabolism",
issn = "2352-3859",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Cheese intake lowers plasma cholesterol concentrations without increasing bile acid excretion

AU - Hjerpsted, Julie Bousgaard

AU - Dragsted, Lars Ove

AU - Tholstrup, Tine

N1 - CURIS 2016 NEXS 147

PY - 2016

Y1 - 2016

N2 - Purpose Cheese is a dairy product with high calcium content. It has been suggested that calcium intake may increase fecal excretion of bile acids that would cause a regeneration of bile acids from hepatic cholesterol and thereby result in a lowering of plasma cholesterol concentrations. We aimed to test this hypothesis by assessing bile acid and calcium concentrations in fecal samples from humans after intake of cheese and butter. Methods The study was a randomized, 2 × 6 weeks crossover, dietary intervention study including 23 men and women who replaced part of their habitual dietary fat intake with 13% energy from cheese or butter. Results After 6 weeks of intervention cheese resulted in higher amounts of calcium excreted in feces compared to butter. However, no difference was observed in fecal bile acid output despite lower serum total, LDL and HDL cholesterol concentrations observed with cheese intake. Conclusion We were not able to confirm the hypothesis that calcium from cheese increases the excretion of fecal bile acids. Therefore, the mechanisms responsible for the lowering of cholesterol concentrations with cheese compared to butter intake remains unresolved.

AB - Purpose Cheese is a dairy product with high calcium content. It has been suggested that calcium intake may increase fecal excretion of bile acids that would cause a regeneration of bile acids from hepatic cholesterol and thereby result in a lowering of plasma cholesterol concentrations. We aimed to test this hypothesis by assessing bile acid and calcium concentrations in fecal samples from humans after intake of cheese and butter. Methods The study was a randomized, 2 × 6 weeks crossover, dietary intervention study including 23 men and women who replaced part of their habitual dietary fat intake with 13% energy from cheese or butter. Results After 6 weeks of intervention cheese resulted in higher amounts of calcium excreted in feces compared to butter. However, no difference was observed in fecal bile acid output despite lower serum total, LDL and HDL cholesterol concentrations observed with cheese intake. Conclusion We were not able to confirm the hypothesis that calcium from cheese increases the excretion of fecal bile acids. Therefore, the mechanisms responsible for the lowering of cholesterol concentrations with cheese compared to butter intake remains unresolved.

KW - Bile acid

KW - Blood lipids

KW - Cardiovascular

KW - Cholesterol

KW - Dairy

U2 - 10.1016/j.jnim.2015.11.002

DO - 10.1016/j.jnim.2015.11.002

M3 - Journal article

AN - SCOPUS:84959419752

VL - 3

SP - 12

EP - 17

JO - Journal of Nutrition & Intermediary Metabolism

JF - Journal of Nutrition & Intermediary Metabolism

SN - 2352-3859

IS - 1

ER -

ID: 162341481