Changes in nocturnal heart rate variability in people living with HIV during the first year of antiretroviral therapy compared to HIV-uninfected community controls

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Changes in nocturnal heart rate variability in people living with HIV during the first year of antiretroviral therapy compared to HIV-uninfected community controls. / Kavishe, Bazil Baltazar; PrayGod, George; Brage, Søren; Kitilya, Brenda Wilfred; Faurholt-Jepsen, Daniel; Todd, Jim; Jeremiah, Kidola; Filteau, Suzanne; Olsen, Mette Frahm; Peck, Robert.

I: J A I D S, Bind 93, Nr. 3, 2023, s. 208-212.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Kavishe, BB, PrayGod, G, Brage, S, Kitilya, BW, Faurholt-Jepsen, D, Todd, J, Jeremiah, K, Filteau, S, Olsen, MF & Peck, R 2023, 'Changes in nocturnal heart rate variability in people living with HIV during the first year of antiretroviral therapy compared to HIV-uninfected community controls', J A I D S, bind 93, nr. 3, s. 208-212. https://doi.org/10.1097/QAI.0000000000003191

APA

Kavishe, B. B., PrayGod, G., Brage, S., Kitilya, B. W., Faurholt-Jepsen, D., Todd, J., Jeremiah, K., Filteau, S., Olsen, M. F., & Peck, R. (2023). Changes in nocturnal heart rate variability in people living with HIV during the first year of antiretroviral therapy compared to HIV-uninfected community controls. J A I D S, 93(3), 208-212. https://doi.org/10.1097/QAI.0000000000003191

Vancouver

Kavishe BB, PrayGod G, Brage S, Kitilya BW, Faurholt-Jepsen D, Todd J o.a. Changes in nocturnal heart rate variability in people living with HIV during the first year of antiretroviral therapy compared to HIV-uninfected community controls. J A I D S. 2023;93(3):208-212. https://doi.org/10.1097/QAI.0000000000003191

Author

Kavishe, Bazil Baltazar ; PrayGod, George ; Brage, Søren ; Kitilya, Brenda Wilfred ; Faurholt-Jepsen, Daniel ; Todd, Jim ; Jeremiah, Kidola ; Filteau, Suzanne ; Olsen, Mette Frahm ; Peck, Robert. / Changes in nocturnal heart rate variability in people living with HIV during the first year of antiretroviral therapy compared to HIV-uninfected community controls. I: J A I D S. 2023 ; Bind 93, Nr. 3. s. 208-212.

Bibtex

@article{591a7342e4994347a81421cb9d2d57b3,
title = "Changes in nocturnal heart rate variability in people living with HIV during the first year of antiretroviral therapy compared to HIV-uninfected community controls",
abstract = "Background: Higher nocturnal heart rate and lower nocturnal heart rate variability (HRV) is associated with increased cardiovascular disease mortality. Longitudinal studies on nocturnal HRV in people living with HIV (PLWH) are lacking.Methods: We conducted a one-year prospective cohort study of adult PLWH and HIV-uninfected community controls in north-western Tanzania. At enrollment, we collected data on cardiovascular risk factors and tested blood samples for hemoglobin, insulin, CD4 cell count and C-reactive protein. We measured nocturnal HRV and heart rate at baseline and first year follow-up. Mixed effect linear regression was used to determine predictors of lower HRV.Results: Of the 111 enrolled participants (74 PLWH and 37 HIV-uninfected), 57.7% were female and the median age was 40 years. Over one year of follow-up, the average nocturnal heart rate was 4.5 beats/minute higher in PLWH (p=0.006). In the fully adjusted model (with age, sex, nocturnal heart rate and diabetes), average nocturnal HRV was 10.5 milliseconds lower in PLWH compared to HIV-uninfected adults (p=0.03). Unlike with nocturnal heart rate, nocturnal HRV did not improve after one year of ART in PLWH or HIV-uninfected (fully adjusted change = -2.5 milliseconds, p=0.45). Lower educational attainment, lesser pancreatic β-cell function and anemia were associated with higher HRV.Conclusions: Nocturnal parasympathetic nervous system function was persistently lower in PLWH compared to HIV-uninfected even after antiretroviral therapy initiation. Improving nocturnal autonomic nervous system function could be a target for cardiovascular disease prevention in PLWH.",
keywords = "Faculty of Science, Heart rate variability, Heart rate, People living with HIV, Cardiovascular disease",
author = "Kavishe, {Bazil Baltazar} and George PrayGod and S{\o}ren Brage and Kitilya, {Brenda Wilfred} and Daniel Faurholt-Jepsen and Jim Todd and Kidola Jeremiah and Suzanne Filteau and Olsen, {Mette Frahm} and Robert Peck",
note = "Copyright {\textcopyright} 2023 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2023",
doi = "10.1097/QAI.0000000000003191",
language = "English",
volume = "93",
pages = "208--212",
journal = "J A I D S",
issn = "1525-4135",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Changes in nocturnal heart rate variability in people living with HIV during the first year of antiretroviral therapy compared to HIV-uninfected community controls

AU - Kavishe, Bazil Baltazar

AU - PrayGod, George

AU - Brage, Søren

AU - Kitilya, Brenda Wilfred

AU - Faurholt-Jepsen, Daniel

AU - Todd, Jim

AU - Jeremiah, Kidola

AU - Filteau, Suzanne

AU - Olsen, Mette Frahm

AU - Peck, Robert

N1 - Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

PY - 2023

Y1 - 2023

N2 - Background: Higher nocturnal heart rate and lower nocturnal heart rate variability (HRV) is associated with increased cardiovascular disease mortality. Longitudinal studies on nocturnal HRV in people living with HIV (PLWH) are lacking.Methods: We conducted a one-year prospective cohort study of adult PLWH and HIV-uninfected community controls in north-western Tanzania. At enrollment, we collected data on cardiovascular risk factors and tested blood samples for hemoglobin, insulin, CD4 cell count and C-reactive protein. We measured nocturnal HRV and heart rate at baseline and first year follow-up. Mixed effect linear regression was used to determine predictors of lower HRV.Results: Of the 111 enrolled participants (74 PLWH and 37 HIV-uninfected), 57.7% were female and the median age was 40 years. Over one year of follow-up, the average nocturnal heart rate was 4.5 beats/minute higher in PLWH (p=0.006). In the fully adjusted model (with age, sex, nocturnal heart rate and diabetes), average nocturnal HRV was 10.5 milliseconds lower in PLWH compared to HIV-uninfected adults (p=0.03). Unlike with nocturnal heart rate, nocturnal HRV did not improve after one year of ART in PLWH or HIV-uninfected (fully adjusted change = -2.5 milliseconds, p=0.45). Lower educational attainment, lesser pancreatic β-cell function and anemia were associated with higher HRV.Conclusions: Nocturnal parasympathetic nervous system function was persistently lower in PLWH compared to HIV-uninfected even after antiretroviral therapy initiation. Improving nocturnal autonomic nervous system function could be a target for cardiovascular disease prevention in PLWH.

AB - Background: Higher nocturnal heart rate and lower nocturnal heart rate variability (HRV) is associated with increased cardiovascular disease mortality. Longitudinal studies on nocturnal HRV in people living with HIV (PLWH) are lacking.Methods: We conducted a one-year prospective cohort study of adult PLWH and HIV-uninfected community controls in north-western Tanzania. At enrollment, we collected data on cardiovascular risk factors and tested blood samples for hemoglobin, insulin, CD4 cell count and C-reactive protein. We measured nocturnal HRV and heart rate at baseline and first year follow-up. Mixed effect linear regression was used to determine predictors of lower HRV.Results: Of the 111 enrolled participants (74 PLWH and 37 HIV-uninfected), 57.7% were female and the median age was 40 years. Over one year of follow-up, the average nocturnal heart rate was 4.5 beats/minute higher in PLWH (p=0.006). In the fully adjusted model (with age, sex, nocturnal heart rate and diabetes), average nocturnal HRV was 10.5 milliseconds lower in PLWH compared to HIV-uninfected adults (p=0.03). Unlike with nocturnal heart rate, nocturnal HRV did not improve after one year of ART in PLWH or HIV-uninfected (fully adjusted change = -2.5 milliseconds, p=0.45). Lower educational attainment, lesser pancreatic β-cell function and anemia were associated with higher HRV.Conclusions: Nocturnal parasympathetic nervous system function was persistently lower in PLWH compared to HIV-uninfected even after antiretroviral therapy initiation. Improving nocturnal autonomic nervous system function could be a target for cardiovascular disease prevention in PLWH.

KW - Faculty of Science

KW - Heart rate variability

KW - Heart rate

KW - People living with HIV

KW - Cardiovascular disease

U2 - 10.1097/QAI.0000000000003191

DO - 10.1097/QAI.0000000000003191

M3 - Journal article

C2 - 36961954

VL - 93

SP - 208

EP - 212

JO - J A I D S

JF - J A I D S

SN - 1525-4135

IS - 3

ER -

ID: 340359835