Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans

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Standard

Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans. / Rasmussen, Peter; Nordsborg, Nikolai; Taudorf, Sarah; Sørensen, Henrik; Berg, Ronan M G; Jacobs, Robert A; Bailey, Damian M; Olsen, Niels V; Secher, Niels H; Møller, Kirsten; Lundby, Carsten.

I: F A S E B Journal, Bind 26, Nr. 5, 2012, s. 1831-1834.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rasmussen, P, Nordsborg, N, Taudorf, S, Sørensen, H, Berg, RMG, Jacobs, RA, Bailey, DM, Olsen, NV, Secher, NH, Møller, K & Lundby, C 2012, 'Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans', F A S E B Journal, bind 26, nr. 5, s. 1831-1834. https://doi.org/10.1096/fj.11-191692

APA

Rasmussen, P., Nordsborg, N., Taudorf, S., Sørensen, H., Berg, R. M. G., Jacobs, R. A., Bailey, D. M., Olsen, N. V., Secher, N. H., Møller, K., & Lundby, C. (2012). Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans. F A S E B Journal, 26(5), 1831-1834. https://doi.org/10.1096/fj.11-191692

Vancouver

Rasmussen P, Nordsborg N, Taudorf S, Sørensen H, Berg RMG, Jacobs RA o.a. Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans. F A S E B Journal. 2012;26(5):1831-1834. https://doi.org/10.1096/fj.11-191692

Author

Rasmussen, Peter ; Nordsborg, Nikolai ; Taudorf, Sarah ; Sørensen, Henrik ; Berg, Ronan M G ; Jacobs, Robert A ; Bailey, Damian M ; Olsen, Niels V ; Secher, Niels H ; Møller, Kirsten ; Lundby, Carsten. / Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans. I: F A S E B Journal. 2012 ; Bind 26, Nr. 5. s. 1831-1834.

Bibtex

@article{67197865da0a4146a889ce59c5d7ced0,
title = "Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans",
abstract = "Erythropoietin (EPO) preserves arterial oxygen content by controlling red blood cell and plasma volumes. Synthesis of EPO was long thought to relate inversely to renal oxygenation, but in knockout mice, brain and skin have been identified as essential for the acute hypoxic EPO response. Whether these findings apply to humans remains unknown. We exposed healthy young subjects to hypoxia (equivalent to 3800 m) and measured EPO in arterial and jugular venous plasma and in cerebrospinal fluid. To examine the role of the skin for EPO production during hypoxia, subjects were exposed to 8 h of hypobaric hypoxia with or without breathing oxygen-enriched air to ensure systemic normoxemia. With 9 h of hypoxia, arterial EPO increased (from 6.0±2.2 to 22.0±6.0 mU/ml, n=11, P",
author = "Peter Rasmussen and Nikolai Nordsborg and Sarah Taudorf and Henrik S{\o}rensen and Berg, {Ronan M G} and Jacobs, {Robert A} and Bailey, {Damian M} and Olsen, {Niels V} and Secher, {Niels H} and Kirsten M{\o}ller and Carsten Lundby",
note = "CURIS 2012 5200 024",
year = "2012",
doi = "10.1096/fj.11-191692",
language = "English",
volume = "26",
pages = "1831--1834",
journal = "F A S E B Journal",
issn = "0892-6638",
publisher = "Federation of American Societies for Experimental Biology",
number = "5",

}

RIS

TY - JOUR

T1 - Brain and skin do not contribute to the systemic rise in erythropoietin during acute hypoxia in humans

AU - Rasmussen, Peter

AU - Nordsborg, Nikolai

AU - Taudorf, Sarah

AU - Sørensen, Henrik

AU - Berg, Ronan M G

AU - Jacobs, Robert A

AU - Bailey, Damian M

AU - Olsen, Niels V

AU - Secher, Niels H

AU - Møller, Kirsten

AU - Lundby, Carsten

N1 - CURIS 2012 5200 024

PY - 2012

Y1 - 2012

N2 - Erythropoietin (EPO) preserves arterial oxygen content by controlling red blood cell and plasma volumes. Synthesis of EPO was long thought to relate inversely to renal oxygenation, but in knockout mice, brain and skin have been identified as essential for the acute hypoxic EPO response. Whether these findings apply to humans remains unknown. We exposed healthy young subjects to hypoxia (equivalent to 3800 m) and measured EPO in arterial and jugular venous plasma and in cerebrospinal fluid. To examine the role of the skin for EPO production during hypoxia, subjects were exposed to 8 h of hypobaric hypoxia with or without breathing oxygen-enriched air to ensure systemic normoxemia. With 9 h of hypoxia, arterial EPO increased (from 6.0±2.2 to 22.0±6.0 mU/ml, n=11, P

AB - Erythropoietin (EPO) preserves arterial oxygen content by controlling red blood cell and plasma volumes. Synthesis of EPO was long thought to relate inversely to renal oxygenation, but in knockout mice, brain and skin have been identified as essential for the acute hypoxic EPO response. Whether these findings apply to humans remains unknown. We exposed healthy young subjects to hypoxia (equivalent to 3800 m) and measured EPO in arterial and jugular venous plasma and in cerebrospinal fluid. To examine the role of the skin for EPO production during hypoxia, subjects were exposed to 8 h of hypobaric hypoxia with or without breathing oxygen-enriched air to ensure systemic normoxemia. With 9 h of hypoxia, arterial EPO increased (from 6.0±2.2 to 22.0±6.0 mU/ml, n=11, P

U2 - 10.1096/fj.11-191692

DO - 10.1096/fj.11-191692

M3 - Journal article

C2 - 22321729

VL - 26

SP - 1831

EP - 1834

JO - F A S E B Journal

JF - F A S E B Journal

SN - 0892-6638

IS - 5

ER -

ID: 37588374