Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF)
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF). / Brenna, J Thomas; Akomo, Peter; Bahwere, Paluku; Berkley, James A; Calder, Philip C; Jones, Kelsey D; Liu, Lei; Manary, Mark; Trehan, Indi; Briend, André.
I: B M C Medicine, Bind 13, 117, 2015.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF)
AU - Brenna, J Thomas
AU - Akomo, Peter
AU - Bahwere, Paluku
AU - Berkley, James A
AU - Calder, Philip C
AU - Jones, Kelsey D
AU - Liu, Lei
AU - Manary, Mark
AU - Trehan, Indi
AU - Briend, André
N1 - CURIS 2015 NEXS 215
PY - 2015
Y1 - 2015
N2 - Ready-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA) in neurocognitive and immune development led two independent groups to evaluate RUTFs. Jones et al. (BMC Med 13:93, 2015), in a study in BMC Medicine, and Hsieh et al. (J Pediatr Gastroenterol Nutr 2015), in a study in the Journal of Pediatric Gastroenterology and Nutrition, reformulated RUTFs with altered PUFA content and looked at the effects on circulating omega-3 docosahexaenoic acid (DHA) status as a measure of overall omega-3 status. Supplemental oral administration of omega-3 DHA or reduction of RUTF omega-6 linoleic acid using high oleic peanuts improved DHA status, whereas increasing omega-3 alpha-linolenic acid in RUTF did not. The results of these two small studies are consistent with well-established effects in animal studies and highlight the need for basic and operational research to improve fat composition in support of omega-3-specific development in young children as RUTF use expands.Please see related article: http://www.biomedcentral.com/1741-7015/13/93.
AB - Ready-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA) in neurocognitive and immune development led two independent groups to evaluate RUTFs. Jones et al. (BMC Med 13:93, 2015), in a study in BMC Medicine, and Hsieh et al. (J Pediatr Gastroenterol Nutr 2015), in a study in the Journal of Pediatric Gastroenterology and Nutrition, reformulated RUTFs with altered PUFA content and looked at the effects on circulating omega-3 docosahexaenoic acid (DHA) status as a measure of overall omega-3 status. Supplemental oral administration of omega-3 DHA or reduction of RUTF omega-6 linoleic acid using high oleic peanuts improved DHA status, whereas increasing omega-3 alpha-linolenic acid in RUTF did not. The results of these two small studies are consistent with well-established effects in animal studies and highlight the need for basic and operational research to improve fat composition in support of omega-3-specific development in young children as RUTF use expands.Please see related article: http://www.biomedcentral.com/1741-7015/13/93.
U2 - 10.1186/s12916-015-0352-1
DO - 10.1186/s12916-015-0352-1
M3 - Journal article
C2 - 25980919
VL - 13
JO - BMC Medicine
JF - BMC Medicine
SN - 1741-7015
M1 - 117
ER -
ID: 140168842