Angiogenic response to passive movement and active exercise in individuals with peripheral arterial disease

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Peripheral arterial disease (PAD) is caused by atherosclerosis and is associated with microcirculatory impairments in skeletal muscle. The present study evaluated the angiogenic response to exercise and passive movement in skeletal muscle of PAD patients compared to healthy control subjects. Twenty-one PAD patients and 17 aged controls were randomly assigned to either a passive movement or an active exercise study. Interstitial fluid microdialysate and tissue samples were obtained from the thigh skeletal muscle. Muscle dialysate vascular endothelial growth factor (VEGF) levels were modestly increased in response to either passive movement or active exercise in both subject groups. The basal muscle dialysate level of the angiostatic factor trombospondin-1 protein (TSP-1) was markedly higher (P
TidsskriftJournal of Applied Physiology
Udgave nummer12
Sider (fra-til)1777-1787
Antal sider11
StatusUdgivet - 2013

Bibliografisk note

CURIS 2013 NEXS 268

ID: 61854062