An exercise-inducible metabolite that suppresses feeding and obesity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Veronica L Li
  • Yang He
  • Kévin Contrepois
  • Hailan Liu
  • Joon T Kim
  • Amanda L Wiggenhorn
  • Julia T Tanzo
  • Alan Sheng Hwa Tung
  • Xuchao Lyu
  • Peter James H Zushin
  • Robert S Jansen
  • Basil Michael
  • Kang Yong Loh
  • Andrew C. Yang
  • Wei Wei
  • Stephanie M Terrell
  • Benjamin C Moeller
  • Rick M Arthur
  • Gareth A Wallis
  • Koen van de Wetering
  • Andreas Stahl
  • Steven M Banik
  • Michael P. Snyder
  • Yong Xu
  • Jonathan Z Long

Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic diseases1–5. However, the molecular and cellular mechanisms that mediate the metabolic benefits of physical activity remain unclear6. Here we show that exercise stimulates the production of N-lactoyl-phenylalanine (Lac-Phe), a blood-borne signalling metabolite that suppresses feeding and obesity. The biosynthesis of Lac-Phe from lactate and phenylalanine occurs in CNDP2+ cells, including macrophages, monocytes and other immune and epithelial cells localized to diverse organs. In diet-induced obese mice, pharmacological-mediated increases in Lac-Phe reduces food intake without affecting movement or energy expenditure. Chronic administration of Lac-Phe decreases adiposity and body weight and improves glucose homeostasis. Conversely, genetic ablation of Lac-Phe biosynthesis in mice increases food intake and obesity following exercise training. Last, large activity-inducible increases in circulating Lac-Phe are also observed in humans and racehorses, establishing this metabolite as a molecular effector associated with physical activity across multiple activity modalities and mammalian species. These data define a conserved exercise-inducible metabolite that controls food intake and influences systemic energy balance.

OriginalsprogEngelsk
TidsskriftNature
Vol/bind606
Sider (fra-til)785-790
Antal sider6
ISSN0028-0836
DOI
StatusUdgivet - 2022

Bibliografisk note

CURIS 2022 NEXS 161

Funding Information:
We thank members of the Long, Xu, Snyder, Richter and Svensson laboratories, and L. Sylow for helpful discussions. This work was supported by the NIH (DK124265 and DK130541 to J.Z.L.; DK113954, DK115761, DK117281 and DK120858 to Y.X.; GM113854 to V.L.L.; and AR072695 to K.v.d.W), the Ono Pharma Foundation (research grant to J.Z.L.), BASF (research grant to J.Z.L.), the USDA (51000-064-01S to Y.X.), the American Heart Association (20POST35120600 to Y.H.), the Novo Nordisk Foundation (NNF17OC0027274 and NNF18OC00334072 to E.A.R.) and PXE International (research grant to K.v.d.W.).

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.

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