Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle

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Standard

Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle. / Richter, Erik A.; Ruderman, N B; Galbo, H.

I: Acta Physiologica Scandinavica, Bind 116, Nr. 3, 1982, s. 215-222.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Richter, EA, Ruderman, NB & Galbo, H 1982, 'Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle', Acta Physiologica Scandinavica, bind 116, nr. 3, s. 215-222. https://doi.org/10.1111/j.1748-1716.1982.tb07133.x

APA

Richter, E. A., Ruderman, N. B., & Galbo, H. (1982). Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle. Acta Physiologica Scandinavica, 116(3), 215-222. https://doi.org/10.1111/j.1748-1716.1982.tb07133.x

Vancouver

Richter EA, Ruderman NB, Galbo H. Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle. Acta Physiologica Scandinavica. 1982;116(3):215-222. https://doi.org/10.1111/j.1748-1716.1982.tb07133.x

Author

Richter, Erik A. ; Ruderman, N B ; Galbo, H. / Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle. I: Acta Physiologica Scandinavica. 1982 ; Bind 116, Nr. 3. s. 215-222.

Bibtex

@article{1219f1c7f84748b9aa1601a4c8773ed7,
title = "Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle",
abstract = "The role of alpha- and beta-adrenergic receptor stimulation for the effect of epinephrine on muscle glycogenolysis, glucose- and oxygen uptake and muscle performance was studied in the perfused rat hindquarter at rest and during electrical stimulation (60 contractions/min). Adrenergic stimulation was obtained by epinephrine in a physiological concentration (2.4 X 10(-8) M) and alpha- and beta-adrenergic blockade by 10(-5) M phentolamine and propranolol, respectively. Epinephrine enhanced net glycogenolysis during contractions most markedly in slow-twitch red fibers. In these fibers the effect was mediated by alpha- as well as by beta-adrenergic stimulation, the latter involving production of cAMP, phosphorylase activation and synthase inactivation. In contrast, in fast-twitch fibers only beta-adrenergic mechanisms were involved in the glycogenolytic effect of epinephrine. Moreover, inactivation of synthase was less in these fibers. Epinephrine also increased the net release of lactate from the hindquarter, an effect abolished by combined alpha- and beta-adrenergic blockade but by neither alpha- nor beta-adrenergic blockade alone. Epinephrine increased uptake of oxygen and glucose by stimulation of alpha-adrenergic receptors and had a positive inotropic effect during contractions which was abolished by alpha- as well as by beta-adrenergic blockade. The results indicate that epinephrine has profound effects on contracting muscle, and that these effects are elicited through different combinations of alpha- and beta-adrenergic receptor stimulation.",
keywords = "Adrenergic alpha-Agonists, Adrenergic alpha-Antagonists, Adrenergic beta-Agonists, Adrenergic beta-Antagonists, Animals, Electric Stimulation, Glucose, Glycogen, Lactates, Male, Muscle Contraction, Muscles, Oxygen Consumption, Perfusion, Rats, Rats, Inbred Strains, Sciatic Nerve",
author = "Richter, {Erik A.} and Ruderman, {N B} and H Galbo",
year = "1982",
doi = "10.1111/j.1748-1716.1982.tb07133.x",
language = "English",
volume = "116",
pages = "215--222",
journal = "Acta Physiologica Scandinavica",
issn = "0001-6772",
publisher = "Blackwell Science Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle

AU - Richter, Erik A.

AU - Ruderman, N B

AU - Galbo, H

PY - 1982

Y1 - 1982

N2 - The role of alpha- and beta-adrenergic receptor stimulation for the effect of epinephrine on muscle glycogenolysis, glucose- and oxygen uptake and muscle performance was studied in the perfused rat hindquarter at rest and during electrical stimulation (60 contractions/min). Adrenergic stimulation was obtained by epinephrine in a physiological concentration (2.4 X 10(-8) M) and alpha- and beta-adrenergic blockade by 10(-5) M phentolamine and propranolol, respectively. Epinephrine enhanced net glycogenolysis during contractions most markedly in slow-twitch red fibers. In these fibers the effect was mediated by alpha- as well as by beta-adrenergic stimulation, the latter involving production of cAMP, phosphorylase activation and synthase inactivation. In contrast, in fast-twitch fibers only beta-adrenergic mechanisms were involved in the glycogenolytic effect of epinephrine. Moreover, inactivation of synthase was less in these fibers. Epinephrine also increased the net release of lactate from the hindquarter, an effect abolished by combined alpha- and beta-adrenergic blockade but by neither alpha- nor beta-adrenergic blockade alone. Epinephrine increased uptake of oxygen and glucose by stimulation of alpha-adrenergic receptors and had a positive inotropic effect during contractions which was abolished by alpha- as well as by beta-adrenergic blockade. The results indicate that epinephrine has profound effects on contracting muscle, and that these effects are elicited through different combinations of alpha- and beta-adrenergic receptor stimulation.

AB - The role of alpha- and beta-adrenergic receptor stimulation for the effect of epinephrine on muscle glycogenolysis, glucose- and oxygen uptake and muscle performance was studied in the perfused rat hindquarter at rest and during electrical stimulation (60 contractions/min). Adrenergic stimulation was obtained by epinephrine in a physiological concentration (2.4 X 10(-8) M) and alpha- and beta-adrenergic blockade by 10(-5) M phentolamine and propranolol, respectively. Epinephrine enhanced net glycogenolysis during contractions most markedly in slow-twitch red fibers. In these fibers the effect was mediated by alpha- as well as by beta-adrenergic stimulation, the latter involving production of cAMP, phosphorylase activation and synthase inactivation. In contrast, in fast-twitch fibers only beta-adrenergic mechanisms were involved in the glycogenolytic effect of epinephrine. Moreover, inactivation of synthase was less in these fibers. Epinephrine also increased the net release of lactate from the hindquarter, an effect abolished by combined alpha- and beta-adrenergic blockade but by neither alpha- nor beta-adrenergic blockade alone. Epinephrine increased uptake of oxygen and glucose by stimulation of alpha-adrenergic receptors and had a positive inotropic effect during contractions which was abolished by alpha- as well as by beta-adrenergic blockade. The results indicate that epinephrine has profound effects on contracting muscle, and that these effects are elicited through different combinations of alpha- and beta-adrenergic receptor stimulation.

KW - Adrenergic alpha-Agonists

KW - Adrenergic alpha-Antagonists

KW - Adrenergic beta-Agonists

KW - Adrenergic beta-Antagonists

KW - Animals

KW - Electric Stimulation

KW - Glucose

KW - Glycogen

KW - Lactates

KW - Male

KW - Muscle Contraction

KW - Muscles

KW - Oxygen Consumption

KW - Perfusion

KW - Rats

KW - Rats, Inbred Strains

KW - Sciatic Nerve

U2 - 10.1111/j.1748-1716.1982.tb07133.x

DO - 10.1111/j.1748-1716.1982.tb07133.x

M3 - Journal article

C2 - 6132521

VL - 116

SP - 215

EP - 222

JO - Acta Physiologica Scandinavica

JF - Acta Physiologica Scandinavica

SN - 0001-6772

IS - 3

ER -

ID: 154760032