Alpha adrenergic receptor blockade increases capillarisation and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle

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Standard

Alpha adrenergic receptor blockade increases capillarisation and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle. / Mortensen, Stefan Peter; Egginton, Stuart; Madsen, Mads; Hansen, Jonas Bo; Munch, Gregers D W; Iepsen, Ulrik Winning; Åkerström, Thorbjörn; Pedersen, Bente Klarlund; Hellsten, Ylva.

I: Acta Physiologica, Bind 221, Nr. 1, 2017, s. 32-43.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mortensen, SP, Egginton, S, Madsen, M, Hansen, JB, Munch, GDW, Iepsen, UW, Åkerström, T, Pedersen, BK & Hellsten, Y 2017, 'Alpha adrenergic receptor blockade increases capillarisation and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle', Acta Physiologica, bind 221, nr. 1, s. 32-43. https://doi.org/10.1111/apha.12857

APA

Mortensen, S. P., Egginton, S., Madsen, M., Hansen, J. B., Munch, G. D. W., Iepsen, U. W., Åkerström, T., Pedersen, B. K., & Hellsten, Y. (2017). Alpha adrenergic receptor blockade increases capillarisation and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle. Acta Physiologica, 221(1), 32-43. https://doi.org/10.1111/apha.12857

Vancouver

Mortensen SP, Egginton S, Madsen M, Hansen JB, Munch GDW, Iepsen UW o.a. Alpha adrenergic receptor blockade increases capillarisation and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle. Acta Physiologica. 2017;221(1):32-43. https://doi.org/10.1111/apha.12857

Author

Mortensen, Stefan Peter ; Egginton, Stuart ; Madsen, Mads ; Hansen, Jonas Bo ; Munch, Gregers D W ; Iepsen, Ulrik Winning ; Åkerström, Thorbjörn ; Pedersen, Bente Klarlund ; Hellsten, Ylva. / Alpha adrenergic receptor blockade increases capillarisation and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle. I: Acta Physiologica. 2017 ; Bind 221, Nr. 1. s. 32-43.

Bibtex

@article{62653be951f8455b865d090a9895c818,
title = "Alpha adrenergic receptor blockade increases capillarisation and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle",
abstract = "AIM: To investigate the effect of elevated basal shear stress on angiogenesis in humans, and the role of enhanced skeletal muscle capillarisation on blood flow and O2 extraction.METHODS: Limb haemodynamics and O2 extraction was measured at rest and during one-leg knee-extensor exercise (12 and 24W) in 10 healthy untrained young men before and after 4 weeks treatment with an α1 receptor-antagonist (Terazosin, 1-2 mg day(-1) ). Corresponding biopsies were taken from the m. vastus lateralis.RESULTS: Resting leg blood flow was increased by 57% 6 hours following Terazosin treatment (P<0.05), while basal capillary-to-fibre ratio was 1.69±0.08 and increased to 1.90±0.08 after treatment (P<0.05). Leg O2 extraction during knee-extensor exercise was higher (4-5%; P<0.05), leg blood flow and venous lactate levels lower (6-7%; P<0.05), while leg VO2 was not different after Terazosin treatment.CONCLUSIONS: These results demonstrate that daily treatment with an α-adrenergic receptor blocker induces capillary growth in human skeletal muscle, likely due to increased shear stress. The increase in capillarisation resulted in an increased fractional O2 extraction, a lower blood flow and venous lactate levels in the exercising leg. The increase in capillarisation, and concomitant functional readouts in the exercising leg, may provide a basis for novel angiotherapy. This article is protected by copyright. All rights reserved.",
keywords = "Capillarisation, Skeletal muscle, Vasodilatation",
author = "Mortensen, {Stefan Peter} and Stuart Egginton and Mads Madsen and Hansen, {Jonas Bo} and Munch, {Gregers D W} and Iepsen, {Ulrik Winning} and Thorbj{\"o}rn {\AA}kerstr{\"o}m and Pedersen, {Bente Klarlund} and Ylva Hellsten",
note = "CURIS 2017 NEXS 106",
year = "2017",
doi = "10.1111/apha.12857",
language = "English",
volume = "221",
pages = "32--43",
journal = "Acta Physiologica",
issn = "1748-1708",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Alpha adrenergic receptor blockade increases capillarisation and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle

AU - Mortensen, Stefan Peter

AU - Egginton, Stuart

AU - Madsen, Mads

AU - Hansen, Jonas Bo

AU - Munch, Gregers D W

AU - Iepsen, Ulrik Winning

AU - Åkerström, Thorbjörn

AU - Pedersen, Bente Klarlund

AU - Hellsten, Ylva

N1 - CURIS 2017 NEXS 106

PY - 2017

Y1 - 2017

N2 - AIM: To investigate the effect of elevated basal shear stress on angiogenesis in humans, and the role of enhanced skeletal muscle capillarisation on blood flow and O2 extraction.METHODS: Limb haemodynamics and O2 extraction was measured at rest and during one-leg knee-extensor exercise (12 and 24W) in 10 healthy untrained young men before and after 4 weeks treatment with an α1 receptor-antagonist (Terazosin, 1-2 mg day(-1) ). Corresponding biopsies were taken from the m. vastus lateralis.RESULTS: Resting leg blood flow was increased by 57% 6 hours following Terazosin treatment (P<0.05), while basal capillary-to-fibre ratio was 1.69±0.08 and increased to 1.90±0.08 after treatment (P<0.05). Leg O2 extraction during knee-extensor exercise was higher (4-5%; P<0.05), leg blood flow and venous lactate levels lower (6-7%; P<0.05), while leg VO2 was not different after Terazosin treatment.CONCLUSIONS: These results demonstrate that daily treatment with an α-adrenergic receptor blocker induces capillary growth in human skeletal muscle, likely due to increased shear stress. The increase in capillarisation resulted in an increased fractional O2 extraction, a lower blood flow and venous lactate levels in the exercising leg. The increase in capillarisation, and concomitant functional readouts in the exercising leg, may provide a basis for novel angiotherapy. This article is protected by copyright. All rights reserved.

AB - AIM: To investigate the effect of elevated basal shear stress on angiogenesis in humans, and the role of enhanced skeletal muscle capillarisation on blood flow and O2 extraction.METHODS: Limb haemodynamics and O2 extraction was measured at rest and during one-leg knee-extensor exercise (12 and 24W) in 10 healthy untrained young men before and after 4 weeks treatment with an α1 receptor-antagonist (Terazosin, 1-2 mg day(-1) ). Corresponding biopsies were taken from the m. vastus lateralis.RESULTS: Resting leg blood flow was increased by 57% 6 hours following Terazosin treatment (P<0.05), while basal capillary-to-fibre ratio was 1.69±0.08 and increased to 1.90±0.08 after treatment (P<0.05). Leg O2 extraction during knee-extensor exercise was higher (4-5%; P<0.05), leg blood flow and venous lactate levels lower (6-7%; P<0.05), while leg VO2 was not different after Terazosin treatment.CONCLUSIONS: These results demonstrate that daily treatment with an α-adrenergic receptor blocker induces capillary growth in human skeletal muscle, likely due to increased shear stress. The increase in capillarisation resulted in an increased fractional O2 extraction, a lower blood flow and venous lactate levels in the exercising leg. The increase in capillarisation, and concomitant functional readouts in the exercising leg, may provide a basis for novel angiotherapy. This article is protected by copyright. All rights reserved.

KW - Capillarisation

KW - Skeletal muscle

KW - Vasodilatation

U2 - 10.1111/apha.12857

DO - 10.1111/apha.12857

M3 - Journal article

C2 - 28199786

VL - 221

SP - 32

EP - 43

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 1

ER -

ID: 173506276