Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Objectives: An increase in circulating branched-chain amino acids (BCAA) is associated with insulin resistance. Adipose tissue is a potentially important site for BCAA metabolism. It was evaluated whether monomethyl branched-chain fatty acids (mmBCFA) in adipose tissue, which are likely derived from BCAA catabolism, are associated with insulin sensitivity.
Methods: Insulin-stimulated glucose disposal was determined by using the hyperinsulinemic-euglycemic clamp procedure with stable isotope glucose tracer infusion in nine lean and nine obese subjects, and in a separate group of nine obese subjects before and 1 year after Roux-en-Y gastric bypass (RYGB) surgery (38% weight loss). Adipose tissue mmBCFA content was measured in tissue biopsies taken in the basal state.
Results: Total adipose tissue mmBCFA content was ∼30% lower in obese than lean subjects (P = 0.02) and increased by ∼65% after weight loss in the RYGB group (P = 0.01). Adipose tissue mmBCFA content correlated positively with skeletal muscle insulin sensitivity (R2 =35%, P = 0.01, n = 18).
Conclusions: These results demonstrate a novel association between adipose tissue mmBCFA content and obesity-related insulin resistance. Additional studies are needed to determine whether the association between adipose tissue mmBCFA and muscle insulin sensitivity is causal or a simple association.
Originalsprog | Engelsk |
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Tidsskrift | Obesity |
Vol/bind | 23 |
Udgave nummer | 2 |
Sider (fra-til) | 329-334 |
Antal sider | 6 |
ISSN | 1930-7381 |
DOI | |
Status | Udgivet - 2015 |
Eksternt udgivet | Ja |
Bibliografisk note
(Ekstern)
© 2014 The Obesity Society.
ID: 289963282