β2-agonist induces net leg glucose uptake and free fatty acid release at rest but not during exercise in young men

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Standard

β2-agonist induces net leg glucose uptake and free fatty acid release at rest but not during exercise in young men. / Onslev, Johan; Jensen, Jørgen; Bangsbo, Jens; Wojtaszewski, Jørgen; Hostrup, Morten.

I: Journal of Clinical Endocrinology and Metabolism, Bind 104, Nr. 3, 2019, s. 647-657.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Onslev, J, Jensen, J, Bangsbo, J, Wojtaszewski, J & Hostrup, M 2019, 'β2-agonist induces net leg glucose uptake and free fatty acid release at rest but not during exercise in young men', Journal of Clinical Endocrinology and Metabolism, bind 104, nr. 3, s. 647-657. https://doi.org/10.1210/jc.2018-01349

APA

Onslev, J., Jensen, J., Bangsbo, J., Wojtaszewski, J., & Hostrup, M. (2019). β2-agonist induces net leg glucose uptake and free fatty acid release at rest but not during exercise in young men. Journal of Clinical Endocrinology and Metabolism, 104(3), 647-657. https://doi.org/10.1210/jc.2018-01349

Vancouver

Onslev J, Jensen J, Bangsbo J, Wojtaszewski J, Hostrup M. β2-agonist induces net leg glucose uptake and free fatty acid release at rest but not during exercise in young men. Journal of Clinical Endocrinology and Metabolism. 2019;104(3):647-657. https://doi.org/10.1210/jc.2018-01349

Author

Onslev, Johan ; Jensen, Jørgen ; Bangsbo, Jens ; Wojtaszewski, Jørgen ; Hostrup, Morten. / β2-agonist induces net leg glucose uptake and free fatty acid release at rest but not during exercise in young men. I: Journal of Clinical Endocrinology and Metabolism. 2019 ; Bind 104, Nr. 3. s. 647-657.

Bibtex

@article{9694c89542be4919a055374a9f132268,
title = "β2-agonist induces net leg glucose uptake and free fatty acid release at rest but not during exercise in young men",
abstract = "Objective: The role of selective β2-adrenergic stimulation in regulation of leg glucose uptake and free fatty acid (FFA) balance is inadequately explored in humans. The objective of this study was to investigate β2-adrenergic effects on net leg glucose uptake and clearance, as well as FFA balance at rest and during exercise.Design: The study was a randomized, placebo-controlled crossover trial, where 10 healthy men received either infusion of β2-agonist terbutaline (0.2 to 0.4 mg) or placebo. Net leg glucose uptake and clearance, and FFA balance were determined at rest and during 8 min of knee extensor exercise using Fick's principle. Vastus lateralis muscle biopsies were collected at rest and at cessation of exercise. The primary outcome measure was net leg glucose uptake.Results: At rest, net leg glucose uptake and clearance were 0.35 (±0.16) mmol/min and 41 (±17) mL/min (mean ± 95{\%} CI) higher (P < 0.001) for terbutaline than placebo, corresponding to increases of 84{\%} and 70{\%}. During exercise, no treatment differences were observed in net leg glucose uptake, whereas clearance was 101 (±86) mL/min lower (P < 0.05) for terbutaline than placebo. At rest, terbutaline induced a net leg FFA release of 21 (±14) µmol/min, being different from placebo (P = 0.04). During exercise, net leg FFA uptake was not different between the treatments.Conclusions: These observations indicate that β2-agonist alters net leg glucose uptake and clearance, as well as FFA balance in humans, which is associated with myocellular β2-adrenergic and insulin-dependent signaling. Furthermore, the study shows that exercise confounds the β2-adrenergic effect on net leg glucose uptake and FFA balance.",
author = "Johan Onslev and J{\o}rgen Jensen and Jens Bangsbo and J{\o}rgen Wojtaszewski and Morten Hostrup",
note = "CURIS 2019 NEXS 029",
year = "2019",
doi = "10.1210/jc.2018-01349",
language = "English",
volume = "104",
pages = "647--657",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - β2-agonist induces net leg glucose uptake and free fatty acid release at rest but not during exercise in young men

AU - Onslev, Johan

AU - Jensen, Jørgen

AU - Bangsbo, Jens

AU - Wojtaszewski, Jørgen

AU - Hostrup, Morten

N1 - CURIS 2019 NEXS 029

PY - 2019

Y1 - 2019

N2 - Objective: The role of selective β2-adrenergic stimulation in regulation of leg glucose uptake and free fatty acid (FFA) balance is inadequately explored in humans. The objective of this study was to investigate β2-adrenergic effects on net leg glucose uptake and clearance, as well as FFA balance at rest and during exercise.Design: The study was a randomized, placebo-controlled crossover trial, where 10 healthy men received either infusion of β2-agonist terbutaline (0.2 to 0.4 mg) or placebo. Net leg glucose uptake and clearance, and FFA balance were determined at rest and during 8 min of knee extensor exercise using Fick's principle. Vastus lateralis muscle biopsies were collected at rest and at cessation of exercise. The primary outcome measure was net leg glucose uptake.Results: At rest, net leg glucose uptake and clearance were 0.35 (±0.16) mmol/min and 41 (±17) mL/min (mean ± 95% CI) higher (P < 0.001) for terbutaline than placebo, corresponding to increases of 84% and 70%. During exercise, no treatment differences were observed in net leg glucose uptake, whereas clearance was 101 (±86) mL/min lower (P < 0.05) for terbutaline than placebo. At rest, terbutaline induced a net leg FFA release of 21 (±14) µmol/min, being different from placebo (P = 0.04). During exercise, net leg FFA uptake was not different between the treatments.Conclusions: These observations indicate that β2-agonist alters net leg glucose uptake and clearance, as well as FFA balance in humans, which is associated with myocellular β2-adrenergic and insulin-dependent signaling. Furthermore, the study shows that exercise confounds the β2-adrenergic effect on net leg glucose uptake and FFA balance.

AB - Objective: The role of selective β2-adrenergic stimulation in regulation of leg glucose uptake and free fatty acid (FFA) balance is inadequately explored in humans. The objective of this study was to investigate β2-adrenergic effects on net leg glucose uptake and clearance, as well as FFA balance at rest and during exercise.Design: The study was a randomized, placebo-controlled crossover trial, where 10 healthy men received either infusion of β2-agonist terbutaline (0.2 to 0.4 mg) or placebo. Net leg glucose uptake and clearance, and FFA balance were determined at rest and during 8 min of knee extensor exercise using Fick's principle. Vastus lateralis muscle biopsies were collected at rest and at cessation of exercise. The primary outcome measure was net leg glucose uptake.Results: At rest, net leg glucose uptake and clearance were 0.35 (±0.16) mmol/min and 41 (±17) mL/min (mean ± 95% CI) higher (P < 0.001) for terbutaline than placebo, corresponding to increases of 84% and 70%. During exercise, no treatment differences were observed in net leg glucose uptake, whereas clearance was 101 (±86) mL/min lower (P < 0.05) for terbutaline than placebo. At rest, terbutaline induced a net leg FFA release of 21 (±14) µmol/min, being different from placebo (P = 0.04). During exercise, net leg FFA uptake was not different between the treatments.Conclusions: These observations indicate that β2-agonist alters net leg glucose uptake and clearance, as well as FFA balance in humans, which is associated with myocellular β2-adrenergic and insulin-dependent signaling. Furthermore, the study shows that exercise confounds the β2-adrenergic effect on net leg glucose uptake and FFA balance.

U2 - 10.1210/jc.2018-01349

DO - 10.1210/jc.2018-01349

M3 - Journal article

C2 - 30285125

VL - 104

SP - 647

EP - 657

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -

ID: 203627914