Role of liver nerves and adrenal medulla in glucose turnover of running rats

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Role of liver nerves and adrenal medulla in glucose turnover of running rats. / Sonne, B; Mikines, K J; Richter, Erik A.; Christensen, N J; Galbo, H.

In: Journal of Applied Physiology, Vol. 59, No. 5, 1985, p. 1640-1646.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sonne, B, Mikines, KJ, Richter, EA, Christensen, NJ & Galbo, H 1985, 'Role of liver nerves and adrenal medulla in glucose turnover of running rats', Journal of Applied Physiology, vol. 59, no. 5, pp. 1640-1646.

APA

Sonne, B., Mikines, K. J., Richter, E. A., Christensen, N. J., & Galbo, H. (1985). Role of liver nerves and adrenal medulla in glucose turnover of running rats. Journal of Applied Physiology, 59(5), 1640-1646.

Vancouver

Sonne B, Mikines KJ, Richter EA, Christensen NJ, Galbo H. Role of liver nerves and adrenal medulla in glucose turnover of running rats. Journal of Applied Physiology. 1985;59(5):1640-1646.

Author

Sonne, B ; Mikines, K J ; Richter, Erik A. ; Christensen, N J ; Galbo, H. / Role of liver nerves and adrenal medulla in glucose turnover of running rats. In: Journal of Applied Physiology. 1985 ; Vol. 59, No. 5. pp. 1640-1646.

Bibtex

@article{875e8b46eccb4a96b5f6c5125bbdae33,
title = "Role of liver nerves and adrenal medulla in glucose turnover of running rats",
abstract = "Sympathetic control of glucose turnover was studied in rats running 35 min at 21 m X min-1 on the level. The rats were surgically liver denervated, adrenodemedullated, or sham operated. Glucose turnover was measured by primed constant infusion of [3-3H]glucose. At rest, the three groups had identical turnover rates and concentrations of glucose in plasma. During running, glucose production always rose rapidly to steady levels. The increase was not influenced by liver denervation but was halved by adrenodemedullation. Similarly, hepatic glycogen depletion was identical in denervated and control rats but reduced after adrenodemedullation. Early in exercise, glucose uptake rose identically in all groups and, in adrenodemedullated rats, matched glucose production. Accordingly, plasma glucose concentration increased in liver-denervated and control rats but was constant in adrenodemedullated rats. Compensatory changes in hormone or substrate levels explaining the lack of effect of liver denervation were not found. In rats with intact adrenals, the plasma epinephrine concentration was increased after 2.5 min of running. It is concluded that, in rats carrying out exercise of moderate intensity and duration, hepatic glycogenolysis and glucose production are not influenced by the autonomic liver nerves but are enhanced by circulating epinephrine.",
keywords = "Adrenal Medulla, Animals, Blood Glucose, Corticosterone, Denervation, Epinephrine, Glucagon, Glucose, Insulin, Lactates, Liver, Liver Glycogen, Male, Muscles, Norepinephrine, Physical Exertion, Rats, Rats, Inbred Strains",
author = "B Sonne and Mikines, {K J} and Richter, {Erik A.} and Christensen, {N J} and H Galbo",
year = "1985",
language = "English",
volume = "59",
pages = "1640--1646",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "5",

}

RIS

TY - JOUR

T1 - Role of liver nerves and adrenal medulla in glucose turnover of running rats

AU - Sonne, B

AU - Mikines, K J

AU - Richter, Erik A.

AU - Christensen, N J

AU - Galbo, H

PY - 1985

Y1 - 1985

N2 - Sympathetic control of glucose turnover was studied in rats running 35 min at 21 m X min-1 on the level. The rats were surgically liver denervated, adrenodemedullated, or sham operated. Glucose turnover was measured by primed constant infusion of [3-3H]glucose. At rest, the three groups had identical turnover rates and concentrations of glucose in plasma. During running, glucose production always rose rapidly to steady levels. The increase was not influenced by liver denervation but was halved by adrenodemedullation. Similarly, hepatic glycogen depletion was identical in denervated and control rats but reduced after adrenodemedullation. Early in exercise, glucose uptake rose identically in all groups and, in adrenodemedullated rats, matched glucose production. Accordingly, plasma glucose concentration increased in liver-denervated and control rats but was constant in adrenodemedullated rats. Compensatory changes in hormone or substrate levels explaining the lack of effect of liver denervation were not found. In rats with intact adrenals, the plasma epinephrine concentration was increased after 2.5 min of running. It is concluded that, in rats carrying out exercise of moderate intensity and duration, hepatic glycogenolysis and glucose production are not influenced by the autonomic liver nerves but are enhanced by circulating epinephrine.

AB - Sympathetic control of glucose turnover was studied in rats running 35 min at 21 m X min-1 on the level. The rats were surgically liver denervated, adrenodemedullated, or sham operated. Glucose turnover was measured by primed constant infusion of [3-3H]glucose. At rest, the three groups had identical turnover rates and concentrations of glucose in plasma. During running, glucose production always rose rapidly to steady levels. The increase was not influenced by liver denervation but was halved by adrenodemedullation. Similarly, hepatic glycogen depletion was identical in denervated and control rats but reduced after adrenodemedullation. Early in exercise, glucose uptake rose identically in all groups and, in adrenodemedullated rats, matched glucose production. Accordingly, plasma glucose concentration increased in liver-denervated and control rats but was constant in adrenodemedullated rats. Compensatory changes in hormone or substrate levels explaining the lack of effect of liver denervation were not found. In rats with intact adrenals, the plasma epinephrine concentration was increased after 2.5 min of running. It is concluded that, in rats carrying out exercise of moderate intensity and duration, hepatic glycogenolysis and glucose production are not influenced by the autonomic liver nerves but are enhanced by circulating epinephrine.

KW - Adrenal Medulla

KW - Animals

KW - Blood Glucose

KW - Corticosterone

KW - Denervation

KW - Epinephrine

KW - Glucagon

KW - Glucose

KW - Insulin

KW - Lactates

KW - Liver

KW - Liver Glycogen

KW - Male

KW - Muscles

KW - Norepinephrine

KW - Physical Exertion

KW - Rats

KW - Rats, Inbred Strains

M3 - Journal article

C2 - 3905756

VL - 59

SP - 1640

EP - 1646

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 5

ER -

ID: 154758505