Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Research output: Contribution to journalReviewResearchpeer-review

Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.
Original languageEnglish
JournalCellular Signalling
Issue number10
Pages (from-to)1546-1554
Number of pages9
Publication statusPublished - 2011

ID: 33716512