Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
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Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle. / Chiu, Tim T; Jensen, Thomas Elbenhardt; Sylow, Lykke; Richter, Erik A.; Klip, Amira.
In: Cellular Signalling, Vol. 23, No. 10, 2011, p. 1546-1554.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
AU - Chiu, Tim T
AU - Jensen, Thomas Elbenhardt
AU - Sylow, Lykke
AU - Richter, Erik A.
AU - Klip, Amira
N1 - CURIS 2011 5200 065
PY - 2011
Y1 - 2011
N2 - Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.
AB - Small Rho family GTPases are important regulators of cellular traffic. Emerging evidence now implicates Rac1 and Rac-dependent actin reorganisation in insulin-induced recruitment of glucose transporter-4 (GLUT4) to the cell surface of muscle cells and mature skeletal muscle. This review summarises the current thinking on the regulation of Rac1 by insulin, the role of Rac-dependent cortical actin remodelling in GLUT4 traffic, and the impact of Rac1 towards insulin resistance in skeletal muscle.
U2 - 10.1016/j.cellsig.2011.05.022
DO - 10.1016/j.cellsig.2011.05.022
M3 - Review
C2 - 21683139
VL - 23
SP - 1546
EP - 1554
JO - Cellular Signalling
JF - Cellular Signalling
SN - 0898-6568
IS - 10
ER -
ID: 33716512