Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6

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To study the relationship between exercise-related muscle proteolysis and the cytokine response, a prolonged eccentric exercise model of one leg was used. Subjects performed two trials [a branched-chain amino acid (BCAA) supplementation and a control trial]. The release of amino acids from muscle during and after the eccentric exercise was decreased in the BCAA trial, suggesting a suppression of net muscle protein degradation. The plasma concentrations of interleukin (IL)-6 increased from 0.75 +/- 0.19 (preexercise) to 5.02 +/- 0.96 pg/ml (2 h postexercise) in the control trial and in the BCAA supplementation trial from 1.07 +/- 0.41 to 4.15 +/- 1.21 pg/ml. Eccentric exercise had no effect on the concentrations of neutrophils, lymphocytes, CD16+/CD56+, CD4+, CD8+, CD14+/CD38+, lymphocyte proliferative response, or cytotoxic activities. BCAA supplementation reduced the concentration of CD14+/CD38+ cells. This study shows that the concentration of IL-6 in plasma is increased after prolonged eccentric exercise and suggests that the cytokine response is independent of the muscle proteolysis that occur during exercise.

Original languageEnglish
JournalAmerican Journal of Physiology: Endocrinology and Metabolism
Issue number1
Pages (from-to)E85-E91
Number of pages7
Publication statusPublished - 1997

    Research areas

  • Adult, Amino Acids, Amino Acids, Branched-Chain, Analysis of Variance, Cytokines, Epinephrine, Exercise, Exercise Test, Food, Fortified, Humans, Interleukin-1, Interleukin-6, Killer Cells, Natural, Leukocyte Count, Lymphocyte Activation, Lymphocyte Count, Male, Muscle, Skeletal, Norepinephrine, Reference Values, Time Factors, Tumor Necrosis Factor-alpha

ID: 154747867