Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6
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Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6. / Rohde, Thomas; MacLean, D A; Richter, Erik A.; Kiens, Bente; Pedersen, Bente Klarlund.
In: American Journal of Physiology: Endocrinology and Metabolism, Vol. 273, No. 1, 1997, p. E85-E91.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6
AU - Rohde, Thomas
AU - MacLean, D A
AU - Richter, Erik A.
AU - Kiens, Bente
AU - Pedersen, Bente Klarlund
PY - 1997
Y1 - 1997
N2 - To study the relationship between exercise-related muscle proteolysis and the cytokine response, a prolonged eccentric exercise model of one leg was used. Subjects performed two trials [a branched-chain amino acid (BCAA) supplementation and a control trial]. The release of amino acids from muscle during and after the eccentric exercise was decreased in the BCAA trial, suggesting a suppression of net muscle protein degradation. The plasma concentrations of interleukin (IL)-6 increased from 0.75 +/- 0.19 (preexercise) to 5.02 +/- 0.96 pg/ml (2 h postexercise) in the control trial and in the BCAA supplementation trial from 1.07 +/- 0.41 to 4.15 +/- 1.21 pg/ml. Eccentric exercise had no effect on the concentrations of neutrophils, lymphocytes, CD16+/CD56+, CD4+, CD8+, CD14+/CD38+, lymphocyte proliferative response, or cytotoxic activities. BCAA supplementation reduced the concentration of CD14+/CD38+ cells. This study shows that the concentration of IL-6 in plasma is increased after prolonged eccentric exercise and suggests that the cytokine response is independent of the muscle proteolysis that occur during exercise.
AB - To study the relationship between exercise-related muscle proteolysis and the cytokine response, a prolonged eccentric exercise model of one leg was used. Subjects performed two trials [a branched-chain amino acid (BCAA) supplementation and a control trial]. The release of amino acids from muscle during and after the eccentric exercise was decreased in the BCAA trial, suggesting a suppression of net muscle protein degradation. The plasma concentrations of interleukin (IL)-6 increased from 0.75 +/- 0.19 (preexercise) to 5.02 +/- 0.96 pg/ml (2 h postexercise) in the control trial and in the BCAA supplementation trial from 1.07 +/- 0.41 to 4.15 +/- 1.21 pg/ml. Eccentric exercise had no effect on the concentrations of neutrophils, lymphocytes, CD16+/CD56+, CD4+, CD8+, CD14+/CD38+, lymphocyte proliferative response, or cytotoxic activities. BCAA supplementation reduced the concentration of CD14+/CD38+ cells. This study shows that the concentration of IL-6 in plasma is increased after prolonged eccentric exercise and suggests that the cytokine response is independent of the muscle proteolysis that occur during exercise.
KW - Adult
KW - Amino Acids
KW - Amino Acids, Branched-Chain
KW - Analysis of Variance
KW - Cytokines
KW - Epinephrine
KW - Exercise
KW - Exercise Test
KW - Food, Fortified
KW - Humans
KW - Interleukin-1
KW - Interleukin-6
KW - Killer Cells, Natural
KW - Leukocyte Count
KW - Lymphocyte Activation
KW - Lymphocyte Count
KW - Male
KW - Muscle, Skeletal
KW - Norepinephrine
KW - Reference Values
KW - Time Factors
KW - Tumor Necrosis Factor-alpha
M3 - Journal article
C2 - 9252483
VL - 273
SP - E85-E91
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
SN - 0193-1849
IS - 1
ER -
ID: 154747867