Ylva Hellsten

Ylva Hellsten

Professor, Head of Section, Professor

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    ORCID: 0000-0002-2435-9558

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    1. Published

      Exercise training improves blood flow to contracting skeletal muscle of older men via enhanced cGMP signaling

      Piil, P. B., Smith Jørgensen, T., Egelund, J., Damsgaard, R., Gliemann, Lasse, Hellsten, Ylva & Nyberg, M. P., 2018, In: Journal of Applied Physiology. 124, 1, p. 109-117 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Exercise training induces thrombogenic benefits in recent but not late postmenopausal females

      Nørregaard, Line Boel, Wickham, Kate Aiko, Ehlers, T., Rocha, Marcos Paulo, Fischer, Mads, Slingsby, M. H. L., Cheung, S. S., Evans, P. A., Bangsbo, Jens & Hellsten, Ylva, 2023, In: American Journal of Physiology: Heart and Circulatory Physiology. 325, 2, p. H346-H361 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Exercise training lowers arterial blood pressure independently of Pannexin 1 in men with essential hypertension

      Møller, S., Hansen, Camilla Collin, Ehlers, T. S., Tamariz-Ellemann, Andrea, Tolborg, S. Á. R., Kurell, M. E., Pérez-Gómez, J., Patrzalek, S. S., Maulitz, C., Hellsten, Ylva & Gliemann, Lasse, 2022, In: Medicine and Science in Sports and Exercise. 54, 9, p. 1417-1427 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Exercise training modulates functional sympatholysis and alpha-adrenergic vasoconstrictor responsiveness in hypertensive and normotensive individuals

      Mortensen, S. P., Nyberg, M. P., Gliemann, Lasse, Thaning, P., Saltin, B. & Hellsten, Ylva, 2014, In: Journal of Physiology. 592, 14, p. 3063-3073 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Exercise training normalizes skeletal muscle vascular endothelial growth factor levels in patients with essential hypertension

      Hansen, A. H., Nielsen, Jens Jung, Saltin, B. & Hellsten, Ylva, 2010, In: Journal of Hypertension. 28, 6, p. 1176-1185 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Exercise training reverses an age‐related attenuation in ATP signaling in human skeletal muscle

      Piil, P., Jørgensen, T. S., Egelund, J., Gliemann, Lasse, Hellsten, Ylva & Nyberg, M., 2019, In: Translational Sports Medicine. 2, 5, p. 248-255 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men

      Olesen, J., Gliemann, Lasse, Biensøe, R. S., Schmidt, J. F., Hellsten, Ylva & Pilegaard, Henriette, 2014, In: Journal of Physiology. 592, 8, p. 1873-1886 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients

      Nørregaard, Line Boel, Wickham, Kate Aiko, Jeppesen, Jan Sommer, Rytter, N., Christoffersen, L. C., Gliemann, Lasse, Lawrence, M., Evans, P. A., Kruuse, Christina Rostrup & Hellsten, Ylva, 2024, In: Thrombosis Journal. 22, 1, 11 p., 35.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Exercise-induced hyperaemia and leg oxygen uptake are not altered during effective inhibition of nitric oxide synthase with NG-nitro-L-arginine methyl ester in humans

      Frandsen, U., Bangsbo, Jens, Sander, M., Höffner, L., Betak, A., Saltin, B. & Hellsten, Ylva, 2001, In: Journal of Physiology. 531, 1, p. 257-264

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Exercise-induced increase in interstitial bradykinin and adenosine concentrations in skeletal muscle and peritendinous tissue in humans

      Langberg, Henning, Bjørn, C., Boushel, R. C., Hellsten, Ylva & Kjær, Michael, 1 Aug 2002, In: Journal of Physiology. 542, 3, p. 977-983 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Exercise-induced skeletal muscle angiogenesis: impact of age, sex, angiocrines and cellular mediators

      Ross, M., Kargl, C. K., Ferguson, R., Gavin, T. P. & Hellsten, Ylva, 2023, In: European Journal of Applied Physiology. 123, 7, p. 1415-1432 18 p.

      Research output: Contribution to journal › Review › Research › peer-review

    12. Published

      Extensive profiling of histidine-containing dipeptides reveals species- and tissue-specific distribution and metabolism in mice, rats, and humans

      Van der Stede, T., Spaas, J., de Jager, S., De Brandt, J., Hansen, C., Stautemas, J., Vercammen, B., De Baere, S., Croubels, S., Van Assche, C-H., Pastor, B. C., Vandenbosch, M., Van Thienen, R., Verboven, K., Hansen, D., Bové, T., Lapauw, B., Van Praet, C., Decaestecker, K., Vanaudenaerde, B. & 4 others, Eijnde, B. O., Gliemann, Lasse, Hellsten, Ylva & Derave, W., 2023, In: Acta Physiologica. 239, 1, 21 p., e14020.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Extensive profiling of histidine-containing dipeptides reveals species-specific distribution and metabolism in mice, rats and humans

      Van der Stede, Thibaux Firmin F, Spaas, J., Jager, S. D., Brandt, J. D., Hansen, Camilla Collin, Vercammen, B., Baere, S. D., Croubels, S., Thienen, R. V., Verboven, K., Hansen, D., Bové, T., Lapauw, B., Praet, C. V., Decaestecker, K., Vanaudenaerde, B., Eijnde, B. O., Gliemann, Lasse, Hellsten, Ylva & Derave, W., 19 Feb 2023, bioRxiv, p. 1-31, 31 p.

      Research output: Working paper › Preprint

    14. Published

      Extracellular formation and uptake of adenosine during skeletal muscle contraction in the rat: role of adenosine transporters

      Lynge, J., Juel, C. & Hellsten, Ylva, 2001, In: Journal of Physiology. 537, 2, p. 597-605 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Formation of hydrogen peroxide and nitric oxide in rat skeletal muscle cells during contractions

      Silveira, L. R., Pereira-Da-Silva, L., Juel, C. & Hellsten, Ylva, 2003, In: Free Radical Biology & Medicine. 35, 5, p. 455-464 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Four weeks of speed endurance training reduces energy expenditure during exercise and maintains muscle oxidative capacity despite a reduction in training volume

      Iaia, F. M., Hellsten, Ylva, Nielsen, Jens Jung, Fernström, M., Sahlin, K. & Bangsbo, Jens, 2009, In: Journal of Applied Physiology. 106, 1, p. 73-80 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Functional sympatholysis in mouse skeletal muscle involves sarcoplasmic reticulum swelling in arterial smooth muscle cells

      van der Horst, Jennifer, Møller, S., Kjeldsen, Sasha Alexandra Sampson, Wojtaszewski, Jørgen F P, Hellsten, Ylva & Jepps, Thomas Andrew Qvistgaard, 2021, In: Physiological Reports. 9, 23, 10 p., e15133.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Glycogen regulated AMP-activated protein kinase activity and acetylCoA carboxylase phosphorylation during exercise

      MacDonald, C. S., Wojtaszewski, Jørgen F P, Kiens, Bente, Nielsen, J. N., Hardie, G., Kemp, B., Hellsten, Ylva & Richter, Erik A., 2002, In: Japanese Journal of Physical Fitness and Sports Medicine. 51, 1, p. 64 1 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    19. Published

      Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle

      Wojtaszewski, Jørgen F P, Jørgensen, S. B., Hellsten, Ylva, Hardie, D. G. & Richter, Erik A., 2002, In: Diabetes. 51, 2, p. 284-292

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells

      Hansen, Camilla Collin, Olsen, K., Pilegaard, Henriette, Bangsbo, Jens, Gliemann, Lasse & Hellsten, Ylva, 2021, In: Physiological Reports. 9, 14, 17 p., e14855.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      High-intensity exercise training improves basal platelet prostacyclin sensitivity and potentiates the response to dual anti-platelet therapy in postmenopausal women

      Wickham, Kate Aiko, Nørregaard, Line Boel, Slingsby, M. H. L., Cheung, S. S. & Hellsten, Ylva, 2022, In: Biomolecules. 12, 10, 19 p., 1501.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      High-intensity interval, but not endurance training induces muscle fiber type-specific subsarcolemmal lipid droplet size reduction in type 2 diabetic patients

      Koh, H. E., Ørtenblad, N., Winding, K. M., Hellsten, Ylva, Mortensen, S. P. & Nielsen, J., 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 5, p. E872-E884 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans

      Van der Stede, Thibaux Firmin F, Blancquaert, L., Stassen, F., Everaert, I., Van Thienen, R., Vervaet, C., Gliemann, Lasse, Hellsten, Ylva & Derave, W., 2021, In: Science Advances. 7, 16, 11 p., abf2856.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Homage to August Krogh celebrating the 90th anniversary of his Nobel prize in Physiology or Medicine

      Larsen, Erik Hviid, Hellsten, Ylva & Wojtaszewski, Jørgen F P, 2011, In: Acta Physiologica (Print). 202, 3, p. 211-212 2 p.

      Research output: Contribution to journal › Editorial › Research › peer-review

    25. Published

      Hyperinsulinemia does not cause de novo capillary recruitment in rat skeletal muscle

      Åkerström, T., Goldman, D., Nilsson, F., Milkovich, S. L., Fraser, G. M., Brand, C. L., Hellsten, Ylva & Ellis, C. G., 2020, In: Microcirculation. 27, 2, 15 p., e12593.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      IMP metabolism in human skeletal muscle after exhaustive exercise

      Tullson, P. C., Bangsbo, Jens, Hellsten, Ylva & Richter, Erik A., 1995, In: Journal of Applied Physiology. 78, 1, p. 146-152 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Immunohistochemical localization of xanthine oxidase in human cardiac and skeletal muscle

      Hellsten-Westing, Y. & Hellsten, Ylva, 1993, In: Histochemistry. 100, 3, p. 215-222 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Impact of β-adrenergic signaling in PGC-1α-mediated adaptations in mouse skeletal muscle

      Brandt, N., Nielsen, L., Buch, B. T., Gudiksen, Anders, Jørgensen, Stine Ringholm, Hellsten, Ylva, Bangsbo, Jens & Pilegaard, Henriette, 1 Jan 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 314, 1, p. E1-E20 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Impaired formation of vasodilators in peripheral tissue in essential hypertension is normalized by exercise training: role of adenosine and prostacyclin

      Hellsten, Ylva, Gliemann, Lasse, Thaning, P., Nyberg, M. P. & Mortensen, S. P., 2012, In: Journal of Hypertension. 30, 10, p. 2007-2014 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Increased expression of xanthine oxidase and insulin-like growth factor I (IGF-I) immunoreactivity in skeletal muscle after strenuous exercise in humans

      Hellsten, Ylva, Hansson, H. A., Johnson, L., Frandsen, U. & Sjödin, B., 1996, In: Acta physiologica Scandinavica. 157, 2, p. 191-197 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Increased skeletal muscle capillarization enhances insulin sensitivity

      Åkerström, T., Laub, L., Vedel, K., Brand, C. L., Pedersen, Bente Klarlund, Kaufmann Lindqvist, A., Wojtaszewski, Jørgen F P & Hellsten, Ylva, 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 307, 12, p. E1105-E1116 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Indication of in vivo xanthine oxidase activity in human skeletal muscle during exercise

      Hellsten, Ylva, Ahlborg, G., Jensen-Urstad, M. & Sjödin, B., 1988, In: Acta physiologica Scandinavica. 134, 1, p. 159-160 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Inducible deletion of skeletal muscle AMPKα 1 reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

      Hingst, J. R., Kjøbsted, R., Birk, J. B., Jørgensen, N. O., Larsen, M. R., Kido, K., Larsen, J. K., Kjeldsen, S. A. S., Fentz, J., Frøsig, C., Holm, S., Fritzen, A. M., Dohlmann, T. L., Larsen, S., Foretz, M., Viollet, B., Schjerling, P., Overby, P., Halling, J. F., Pilegaard, H. & 2 others, Hellsten, Ylva & Wojtaszewski, Jørgen F P, 2020, In: Molecular Metabolism. 40, 17 p., 101028.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Infusion of ATP increases leg oxygen delivery but not oxygen uptake in the initial phase of intense knee-extensor exercise in humans

      Nyberg, M. P., Christensen, P. M., Mortensen, S. P., Hellsten, Ylva & Bangsbo, Jens, 2014, In: Experimental Physiology. 99, 10, p. 1399-1408 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Inhibition of nitric oxide and prostaglandins, but not endothelial-derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg

      Mortensen, S. P., González-Alonso, J., Damsgaard, R., Saltin, B. & Hellsten, Ylva, 2007, In: Journal of Physiology. 581, 2, p. 853-861 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle

      Frandsen, U., Bangsbo, Jens, Langberg, Henning, Saltin, B. & Hellsten, Ylva, 2000, In: Journal of Vascular Research. 37, 4, p. 297-302 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Inhibition of nitric oxide synthesis by systemic NG-monomethyl-L-arginine administration in humans: Effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle

      Frandsen, U., Bangsbo, Jens, Langberg, Henning, Saltin, B. & Hellsten, Ylva, 2000, In: Journal of Vascular Research. 37, 4, p. 297-302 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Insulin-induced membrane permeability to glucose in human muscles at rest and following exercise

      McConell, G. K., Sjøberg, K. A., Ceutz, F., Gliemann, Lasse, Nyberg, M. P., Hellsten, Ylva, Frøsig, C., Kiens, Bente, Wojtaszewski, Jørgen F P & Richter, Erik A., 2020, In: Journal of Physiology. 598, 2, p. 303-315 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Intense intermittent exercise provides weak stimulus for vascular endothelial growth factor secretion and capillary growth in skeletal muscle

      Høier, B., Passos, M., Bangsbo, Jens & Hellsten, Ylva, 2013, In: Experimental Physiology. 98, 2, p. 585-597 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Intense interval training enhances human skeletal muscle oxygen uptake in the initial phase of dynamic exercise at high but not at low intensities

      Krustrup, P., Hellsten, Ylva & Bangsbo, Jens, 2004, In: Journal of Physiology. 559, 1, p. 335-345

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Interstitial and plasma adenosine stimulate nitric oxide and prostacyclin formation in human skeletal muscle

      Nyberg, M. P., Mortensen, S. P., Thaning, P., Saltin, B. & Hellsten, Ylva, 2010, In: Hypertension. 56, 6, p. 1102-1108 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Is the Pannexin-1 channel a mechanism underlying hypertension in humans? A translational study of human hypertension

      Gliemann, Lasse, Tamariz-Ellemann, Andrea, Hansen, Camilla Collin, Ehlers, T. S., Møller, S. & Hellsten, Ylva, 2022, In: Hypertension. 79, 5, p. 1132-1143 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Ischemic preconditioning improves microvascular endothelial function in remote vasculature by enhanced prostacyclin production

      Rytter, N., Carter, H., Piil, P., Sørensen, H., Ehlers, T., Jensen, Frederik Holmegaard, Tuxen, C., Jones, H., Thijssen, D., Gliemann, Lasse & Hellsten, Ylva, 2020, In: Journal of the American Heart Association. 9, 15, 22 p., e016017.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Kinetics of lactate and pyruvate transport in cultured rat myotubes

      von Grumbckow, L., Elsner, P., Hellsten, Ylva, Quistorff, B. & Juel, C., 1999, In: BBA General Subjects. 1417, 2, p. 267-275 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Leg blood flow and skeletal muscle microvascular perfusion responses to submaximal exercise in peripheral arterial disease

      Meneses, A. L., Nam, M. C. Y., Bailey, T. G., Magee, R., Golledge, J., Hellsten, Ylva, Keske, M. A., Greaves, K. & Askew, C. D., 2018, In: American Journal of Physiology: Heart and Circulatory Physiology. 315, 5, p. H1425-H1433 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Leg blood flow is impaired during small muscle mass exercise in patients with COPD

      Iepsen, Ulrik Winning, Munch, G. D. W., Rugbjerg, M., Ryrsø, C. K., Secher, Niels H., Hellsten, Ylva, Lange, Peter, Pedersen, Bente Klarlund, Thaning, P. & Mortensen, S. P., 2017, In: Journal of Applied Physiology. 123, 3, p. 624-631 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery

      Christensen, P. M., Nyberg, M. P., Mortensen, S. P., Nielsen, Jens Jung, Secher, Niels H., Damsgaard, R., Hellsten, Ylva & Bangsbo, Jens, 2013, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 305, 3, p. R313-R321 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase

      Nyberg, M. P., Egelund, J., djc739, djc739, Roland, Caroline Borup, Hansen, K. M. B. E., Hergel, I. F., Valbak-Andersen, N., Frikke-Schmidt, Ruth, Stallknecht, Bente Merete, Bangsbo, Jens & Hellsten, Ylva, 2017, In: Journal of Physiology. 595, 9, p. 2969-2983 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Lifelong physical activity determines vascular function in late postmenopausal women

      Gliemann, Lasse, Rytter, N., Tamariz-Ellemann, Andrea, Egelund, J., Brandt, N., Carter, H. H. & Hellsten, Ylva, 2020, In: Medicine and Science in Sports and Exercise. 52, 3, p. 627-636 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans

      Nyberg, M. P., Blackwell, J. R., Damsgaard, R., Jones, A. M., Hellsten, Ylva & Mortensen, S. P., 2012, In: Journal of Physiology. 590, 21, p. 5361-5370 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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