PhD defence: The development and effect of a New Nordic Renal Diet on phosphorus homeostasis in patients with moderate chronic kidney disease
Louise Havkrog Salomo
PhD thesis
by Joseph Wright of Derby
Chronic kidney disease (CKD) is associated with a significantly increased risk of cardiovascular disease (CVD). CVD in CKD is not only related to traditional factors such as hypertension and dyslipidemia, but the disturbance in the calcium-phosphate metabolism and vascular calcifications add a significant risk. CKD patients develop hyperphosphatemia, which has been shown to be associated with high prevalence of cardiovascular morbidity and mortality. There is a need to develop safe and sustainable therapeutic approaches to lower phosphate and FGF23 levels in CKD in order to prevent the vascular calcifications and cardiovascular disease.
The purpose of this PhD thesis was two-fold: first to develop a palatable phosphorus-reduced diet and secondly, to evaluate the diets impact on phosphorus homeostasis in patients with CKD, within a short term dietary intervention.
2019, 134 pages.
Time
23 January 2019, 13:00
Place
Festauditoriet (aud. A1-01.01),
Bülowsvej 17, 1870 Frederiksberg C
Opponents
Professor Lotte Lauritzen (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
Professor and Consultant Nephrologist David Goldsmith, Renal Unit, Guy’s and St Thomas’ Hospital London, UK.
Clinical Professor Lars Rejnmark, Department of Clinical Medicine - The Department of Endocrinology and Metabolism C, Aarhus University, Denmark.
Supervisor
Professor Arne Astrup, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
Co-supervisors
Marianne Rix, Department of Nephrology, Rigshospitalet, Denmark.
Anne-Lise Kamper, Department of Nephrology, Rigshospitalet, Denmark.
The thesis is available for inspection at the library, Nørre Allé 51, DK-2200 Copenhagen N.