PhD defence: Effects of Dietary Factors on Metabolic Regulation

Illustrated with protein pre-meals and short chain fatty acids

Ceyda Tugba Pekmez

PhD thesis

The regulation of energy homeostasis is a complex process influenced by many dietary factors and by the cross-talk between the host and microbiota.

In this thesis, I aimed to investigate the role of certain dietary factors on metabolic regulation using untargeted and targeted metabolomics.

First, I investigated the metabolic fingerprint of protein pre-meals consumed before a high-fat main meal in subjects with metabolic syndrome.

Further, I reviewed the alterations of gut microbiota and the role of short chain fatty acids in early life malnutrition. Lastly, I explored the differences in breastmilk components and their association with fecal short chain fatty acids in relation to infants’ growth.

2019, 215 pages.

Time

17 December 2019, 13:00

Place

Auditorium A1-01.01, Festauditoriet, Bülowsvej 17, Frederiksberg.

Opponents 

Professor Henrik Friis (chair), Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Professor Stine Marie Ulven, Institute of Basic Medical Sciences, University of Oslo, Norway.

Associate Professor Cristina Legido-Quigley, System Medicine Research Group, Steno Diabetes Center, Denmark.

Main supervisor

Professor Lars Ove Dragsted, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.

Co-supervisor

Lena Kirchner Brahe, Department of Nutrition Exercise and Sports, Faculty of Science, University Copenhagen, Denmark.

Professor Kim Fleischer Michaelsen, Department of Nutrition Exercise and Sports, Faculty of Science, University Copenhagen, Denmark.

The thesis is available for inspection at the library, Nørre Allé 51, DK-2200 Copenhagen N.