PhD defence: From Receptors to Systems

Estrogen Signaling and Cardiovascular Aging in Females within a Deep Phenotyping Cohort

Andrea Sofia Tamariz-Ellemann

Cardiovascular disease risk increases sharply in females during the menopausal transition, yet the biological mechanisms underlying this shift remain incompletely understood.

This PhD investigated the role of estrogen-related signaling in vascular aging, spanning molecular studies of estrogen receptor expression in skeletal muscle to integrated assessments of vascular function in humans.

The findings demonstrate age-related alterations in estrogen receptor expression associated with vascular signaling pathways and reveal substantial inter-individual variation in vascular function already in the late reproductive stage.

Central to the work is the establishment of the Women in Healthy Transition (KiSO) Deep Phenotyping cohort, a unique longitudinal study designed to follow cardiovascular agin across the menopausal transition and beyond.

Assessment Committee

Associate Professor Anne Yaël Nossent (chair), Department of nutrition, exercise and sports, University of Copenhagen, Denmark.

Associate Professor Ola Hansson, Lund University.

Professor Severine Lamon, Deakin University.

Supervisors

Associate Professor Lasse Gliemann Hybholt, Department of nutrition, exercise and sports, University of Copenhagen, Denmark.

Professor Ylva Hellsten, Department of nutrition, exercise and sports, University of Copenhagen, Denmark.

Place

Niels Bohr Building, Room: Margrethe Bohr Hall, Jagtvej 132, Building 1, floor 01, 2100, Copenhagen.

Access to the thesis

Email address to gain access to the thesis: aste@nexs.ku.dk.

You will either receive a copy of the thesis or be informed where you can read a physical copy.

Recipients of copies of the thesis are not allowed to share or distribute it due to copyright compliance.