Research priorities in pediatric parenteral nutrition: a consensus and perspective from ESPGHAN/ESPEN/ESPR/CSPEN
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Research priorities in pediatric parenteral nutrition: a consensus and perspective from ESPGHAN/ESPEN/ESPR/CSPEN. / Johnson, Mark J; Lapillonne, Alexandre; Bronsky, Jiri; Domellof, Magnus; Embleton, Nicholas; Iacobelli, Silvia; Jochum, Frank; Joosten, Koen; Kolacek, Sanja; Mihatsch, Walter A; Moltu, Sissel J; Mølgaard, Christian; on behalf of ESPGHAN/ESPEN/ESPR/CSPEN Working Group on Pediatric Parenteral Nutrition.
In: Pediatric Research, Vol. 92, No. 1, 2022, p. 61-70.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Research priorities in pediatric parenteral nutrition: a consensus and perspective from ESPGHAN/ESPEN/ESPR/CSPEN
AU - Johnson, Mark J
AU - Lapillonne, Alexandre
AU - Bronsky, Jiri
AU - Domellof, Magnus
AU - Embleton, Nicholas
AU - Iacobelli, Silvia
AU - Jochum, Frank
AU - Joosten, Koen
AU - Kolacek, Sanja
AU - Mihatsch, Walter A
AU - Moltu, Sissel J
AU - Puntis, John W L
AU - Riskin, Arieh
AU - Shamir, Raanan
AU - Tabbers, Merit M
AU - van Goudoever, Johannes B
AU - Saenz de Pipaon, Miguel
AU - Braegger, Christian
AU - Bronsky, Jiri
AU - Cai, Wei
AU - Campoy, Cristina
AU - Carnielli, Virgilio
AU - Darmaun, Dominique
AU - Decsi, Tamás
AU - Domellof, Magnus
AU - Embleton, Nicholas
AU - Fewtrell, Mary
AU - Mis, Natasa Fidler
AU - Franz, Axel
AU - Goulet, Olivier
AU - Hartman, Corina
AU - Hill, Susan
AU - Hojsak, Iva
AU - Iacobelli, Silvia
AU - Jochum, Frank
AU - Joosten, Koen
AU - Kolacek, Sanja
AU - Koletzko, Berthold
AU - Ksiazyk, Janusz
AU - Lapillonne, Alexandre
AU - Lohner, Szimonetta
AU - Mesotten, Dieter
AU - Mihalyi, Krisztina
AU - Mihatsch, Walter A.
AU - Mimouni, Francis
AU - Mølgaard, Christian
AU - Moltu, Sissel J.
AU - Nomayo, Antonia
AU - Picaud, Charles Jean
AU - Prell, Christine
AU - on behalf of ESPGHAN/ESPEN/ESPR/CSPEN Working Group on Pediatric Parenteral Nutrition
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2022
Y1 - 2022
N2 - Parenteral nutrition is used to treat children that cannot be fully fed by the enteral route. While the revised ESPGHAN/ESPEN/ESPR/CSPEN pediatric parenteral nutrition guidelines provide clear guidance on the use of parenteral nutrition in neonates, infants, and children based on current available evidence, they have helped to crystallize areas where research is lacking or more studies are needed in order to refine recommendations. This paper collates and discusses the research gaps identified by the authors of each section of the guidelines and considers each nutrient or group of nutrients in turn, together with aspects around delivery and organization. The 99 research priorities identified were then ranked in order of importance by clinicians and researchers working in the field using a survey methodology. The highest ranked priority was the need to understand the relationship between total energy intake, rapid catch-up growth, later metabolic function, and neurocognitive outcomes. Research into the optimal intakes of macronutrients needed in order to achieve optimal outcomes also featured prominently. Identifying research priorities in PN should enable research to be focussed on addressing key issues. Multicentre trials, better definition of exposure and outcome variables, and long-term metabolic and developmental follow-up will be key to achieving this. Impact: The recent ESPGHAN/ESPEN/ESPR/CSPEN guidelines for pediatric parenteral nutrition provided updated guidance for providing parenteral nutrition to infants and children, including recommendations for practice. However, in several areas there was a lack of evidence to guide practice, or research questions that remained unanswered. This paper summarizes the key priorities for research in pediatric parenteral nutrition, and ranks them in order of importance according to expert opinion.
AB - Parenteral nutrition is used to treat children that cannot be fully fed by the enteral route. While the revised ESPGHAN/ESPEN/ESPR/CSPEN pediatric parenteral nutrition guidelines provide clear guidance on the use of parenteral nutrition in neonates, infants, and children based on current available evidence, they have helped to crystallize areas where research is lacking or more studies are needed in order to refine recommendations. This paper collates and discusses the research gaps identified by the authors of each section of the guidelines and considers each nutrient or group of nutrients in turn, together with aspects around delivery and organization. The 99 research priorities identified were then ranked in order of importance by clinicians and researchers working in the field using a survey methodology. The highest ranked priority was the need to understand the relationship between total energy intake, rapid catch-up growth, later metabolic function, and neurocognitive outcomes. Research into the optimal intakes of macronutrients needed in order to achieve optimal outcomes also featured prominently. Identifying research priorities in PN should enable research to be focussed on addressing key issues. Multicentre trials, better definition of exposure and outcome variables, and long-term metabolic and developmental follow-up will be key to achieving this. Impact: The recent ESPGHAN/ESPEN/ESPR/CSPEN guidelines for pediatric parenteral nutrition provided updated guidance for providing parenteral nutrition to infants and children, including recommendations for practice. However, in several areas there was a lack of evidence to guide practice, or research questions that remained unanswered. This paper summarizes the key priorities for research in pediatric parenteral nutrition, and ranks them in order of importance according to expert opinion.
U2 - 10.1038/s41390-021-01670-9
DO - 10.1038/s41390-021-01670-9
M3 - Review
C2 - 34475525
AN - SCOPUS:85114718501
VL - 92
SP - 61
EP - 70
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 1
ER -
ID: 280667476