Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes: The PREVIEW Study
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Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes : The PREVIEW Study. / Swindell, Nils; Mackintosh, Kelly; McNarry, Melitta; Stephens, Jeffrey W; Sluik, Diewertje; Fogelholm, Mikael; Drummen, Mathijs; MacDonald, Ian; Martinez, J Alfredo; Handjieva-Darlenska, Teodora; Poppitt, Sally D; Brand-Miller, Jennie; Larsen, Thomas Meinert; Raben, Anne; Stratton, Gareth.
In: Diabetes Care, Vol. 41, No. 3, 2018, p. 562-569.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes
T2 - The PREVIEW Study
AU - Swindell, Nils
AU - Mackintosh, Kelly
AU - McNarry, Melitta
AU - Stephens, Jeffrey W
AU - Sluik, Diewertje
AU - Fogelholm, Mikael
AU - Drummen, Mathijs
AU - MacDonald, Ian
AU - Martinez, J Alfredo
AU - Handjieva-Darlenska, Teodora
AU - Poppitt, Sally D
AU - Brand-Miller, Jennie
AU - Larsen, Thomas Meinert
AU - Raben, Anne
AU - Stratton, Gareth
N1 - CURIS 2018 NEXS 088
PY - 2018
Y1 - 2018
N2 - Objective: The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes.Research design and methods: Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI >25 kg ⋅ m(-2) and impaired fasting glucose (5.6-6.9 mmol ⋅ L(-1)) or impaired glucose tolerance (7.8-11.0 mmol ⋅ L(-1) at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST.Results: Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized β = -0.078 [95% CI -0.128, -0.027]), waist circumference (WC) (β = -0.177 [-0.122, -0.134]), fasting insulin (β = -0.115 [-0.158, -0.072]), 2-h glucose (β = -0.069 [-0.112, -0.025]), triglycerides (β = -0.091 [-0.138, -0.044]), and CRP (β = -0.086 [-0.127, -0.045]). ST was positively associated with HOMA-IR (β = 0.175 [0.114, 0.236]), WC (β = 0.215 [0.026, 0.131]), fasting insulin (β = 0.155 [0.092, 0.219]), triglycerides (β = 0.106 [0.052, 0.16]), CRP (β = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (β = 0.078 [0.026, 0.131]), and diastolic BP (β = 0.106 [0.39, -0.172]). Associations reported between total PA (counts ⋅ min(-1)) and all risk factors were comparable or stronger than for MVPA: HOMA-IR (β = -0.151 [-0.194, -0.107]), WC (β = -0.179 [-0.224, -0.134]), fasting insulin (β = -0.139 [-0.183, -0.096]), 2-h glucose (β = -0.088 [-0.131, -0.045]), triglycerides (β = -0.117 [-0.162, -0.071]), and CRP (β = -0.104 [-0.146, -0.062]).Conclusions: In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.
AB - Objective: The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes.Research design and methods: Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI >25 kg ⋅ m(-2) and impaired fasting glucose (5.6-6.9 mmol ⋅ L(-1)) or impaired glucose tolerance (7.8-11.0 mmol ⋅ L(-1) at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST.Results: Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized β = -0.078 [95% CI -0.128, -0.027]), waist circumference (WC) (β = -0.177 [-0.122, -0.134]), fasting insulin (β = -0.115 [-0.158, -0.072]), 2-h glucose (β = -0.069 [-0.112, -0.025]), triglycerides (β = -0.091 [-0.138, -0.044]), and CRP (β = -0.086 [-0.127, -0.045]). ST was positively associated with HOMA-IR (β = 0.175 [0.114, 0.236]), WC (β = 0.215 [0.026, 0.131]), fasting insulin (β = 0.155 [0.092, 0.219]), triglycerides (β = 0.106 [0.052, 0.16]), CRP (β = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (β = 0.078 [0.026, 0.131]), and diastolic BP (β = 0.106 [0.39, -0.172]). Associations reported between total PA (counts ⋅ min(-1)) and all risk factors were comparable or stronger than for MVPA: HOMA-IR (β = -0.151 [-0.194, -0.107]), WC (β = -0.179 [-0.224, -0.134]), fasting insulin (β = -0.139 [-0.183, -0.096]), 2-h glucose (β = -0.088 [-0.131, -0.045]), triglycerides (β = -0.117 [-0.162, -0.071]), and CRP (β = -0.104 [-0.146, -0.062]).Conclusions: In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.
KW - Journal Article
U2 - 10.2337/dc17-1057
DO - 10.2337/dc17-1057
M3 - Journal article
C2 - 29158249
VL - 41
SP - 562
EP - 569
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 3
ER -
ID: 185994192