Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health. / Samsø Mathiasen, Sally; Kanta, Josephine M.; Frydenberg, Rikke P.; Lundsgaard, Annemarie; Guo, Zheng; Fritzen, Andreas M.; Kiens, Bente; Wiking, Lars; Kleinert, Maximilian.

In: Food and Function, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Samsø Mathiasen, S, Kanta, JM, Frydenberg, RP, Lundsgaard, A, Guo, Z, Fritzen, AM, Kiens, B, Wiking, L & Kleinert, M 2024, 'Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health', Food and Function. https://doi.org/10.1039/d4fo00267a

APA

Samsø Mathiasen, S., Kanta, J. M., Frydenberg, R. P., Lundsgaard, A., Guo, Z., Fritzen, A. M., Kiens, B., Wiking, L., & Kleinert, M. (2024). Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health. Food and Function. https://doi.org/10.1039/d4fo00267a

Vancouver

Samsø Mathiasen S, Kanta JM, Frydenberg RP, Lundsgaard A, Guo Z, Fritzen AM et al. Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health. Food and Function. 2024. https://doi.org/10.1039/d4fo00267a

Author

Samsø Mathiasen, Sally ; Kanta, Josephine M. ; Frydenberg, Rikke P. ; Lundsgaard, Annemarie ; Guo, Zheng ; Fritzen, Andreas M. ; Kiens, Bente ; Wiking, Lars ; Kleinert, Maximilian. / Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health. In: Food and Function. 2024.

Bibtex

@article{b2cf535d05bd4311b8c5efc9b87b4009,

title = "Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health",

abstract = "Dietary short- and medium-chain fatty acids have been shown to elevate circulating ketone bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced mix but in relatively low concentrations. Enriching them could amplify health benefits of dairy products. Here, we used a volatility-based workflow to produce milk fat with a 2-fold enrichment of medium- and short-chain fatty acids (referred to as MSFAT). Our proof-of-concept studies in mice demonstrated that intake of MSFAT increased circulating ketone bodies, reduced blood glucose levels, and suppressed food intake. In humans, ingestion of MSFAT resulted in increased circulating ketone bodies, trended to attenuate (p = 0.07) postprandial glucose excursion, and acutely elevated energy expenditure. Our findings show that milk products enriched with MSFAT may hold significant metabolic advantages.",

author = "{Sams{\o} Mathiasen}, Sally and Kanta, {Josephine M.} and Frydenberg, {Rikke P.} and Annemarie Lundsgaard and Zheng Guo and Fritzen, {Andreas M.} and Bente Kiens and Lars Wiking and Maximilian Kleinert",

note = "Publisher Copyright: {\textcopyright} 2024 The Royal Society of Chemistry.",

year = "2024",

doi = "10.1039/d4fo00267a",

language = "English",

journal = "Food & Function",

issn = "2042-6496",

publisher = "Royal Society of Chemistry",

}

RIS

TY - JOUR

T1 - Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health

AU - Samsø Mathiasen, Sally

AU - Kanta, Josephine M.

AU - Frydenberg, Rikke P.

AU - Lundsgaard, Annemarie

AU - Guo, Zheng

AU - Fritzen, Andreas M.

AU - Kiens, Bente

AU - Wiking, Lars

AU - Kleinert, Maximilian

PY - 2024

Y1 - 2024

N2 - Dietary short- and medium-chain fatty acids have been shown to elevate circulating ketone bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced mix but in relatively low concentrations. Enriching them could amplify health benefits of dairy products. Here, we used a volatility-based workflow to produce milk fat with a 2-fold enrichment of medium- and short-chain fatty acids (referred to as MSFAT). Our proof-of-concept studies in mice demonstrated that intake of MSFAT increased circulating ketone bodies, reduced blood glucose levels, and suppressed food intake. In humans, ingestion of MSFAT resulted in increased circulating ketone bodies, trended to attenuate (p = 0.07) postprandial glucose excursion, and acutely elevated energy expenditure. Our findings show that milk products enriched with MSFAT may hold significant metabolic advantages.

AB - Dietary short- and medium-chain fatty acids have been shown to elevate circulating ketone bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced mix but in relatively low concentrations. Enriching them could amplify health benefits of dairy products. Here, we used a volatility-based workflow to produce milk fat with a 2-fold enrichment of medium- and short-chain fatty acids (referred to as MSFAT). Our proof-of-concept studies in mice demonstrated that intake of MSFAT increased circulating ketone bodies, reduced blood glucose levels, and suppressed food intake. In humans, ingestion of MSFAT resulted in increased circulating ketone bodies, trended to attenuate (p = 0.07) postprandial glucose excursion, and acutely elevated energy expenditure. Our findings show that milk products enriched with MSFAT may hold significant metabolic advantages.

U2 - 10.1039/d4fo00267a

DO - 10.1039/d4fo00267a

M3 - Journal article

AN - SCOPUS:85198074649

JO - Food & Function

JF - Food & Function

SN - 2042-6496

ER -

ID: 399114358

Institut for Idræt og Ernæring