Long-chain polyunsaturated fatty acids in breast-milk and erythrocytes and neurodevelopmental outcomes in Danish late-preterm infants
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Long-chain polyunsaturated fatty acids in breast-milk and erythrocytes and neurodevelopmental outcomes in Danish late-preterm infants. / Andersen, Stine Brøndum; Hellgren, Lars I; Larsen, Mette Krogh; Verder, Henrik; Lauritzen, Lotte.
In: Journal of Pregnancy and Child Health, Vol. 2, No. 3, 1000160, 2015.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Long-chain polyunsaturated fatty acids in breast-milk and erythrocytes and neurodevelopmental outcomes in Danish late-preterm infants
AU - Andersen, Stine Brøndum
AU - Hellgren, Lars I
AU - Larsen, Mette Krogh
AU - Verder, Henrik
AU - Lauritzen, Lotte
N1 - CURIS 2015 NEXS 190
PY - 2015
Y1 - 2015
N2 - Background: The supply of long-chain polyunsaturated fatty acids (LC-PUFA) during pregnancy and early lactation has been shown to affect cognitive development in preterm infants, but the effect on early neurodevelopment of late-preterm infants has not yet been examined.Aim: To examine the fatty acid composition of late-preterm human milk and identify possible associations between infant LC-PUFA status and perinatal as well as 1-year neurobehavioral outcomes.Methods: Mother’s milk and erythrocytes (RBC) were sampled from 53 Danish late-preterm infants (33-36 weeks of gestation) 1 week and 1 month after delivery, and 3 months corrected age. Fatty acid composition was determinedby gas-liquid chromatography. Neurodevelopmental outcomes were assessed by the Nicu Network Neurobehavioral Scale (NNNS) at 1 week and 1 month and the Bayley Scales (BSID-III) at 1 year corrected age.Results: We found that breast-milk content of arachidonic acid (AA) and docosahexaenoic acid (DHA) was similar to reported fatty acid compositions of term human milk. Infant RBC-AA decreased from 1 week to 1 month of age andthe size of the decrease was associated with better NNNS-scores at 1 month, specifically on regulation (p=0.03). Infant RBC-AA at 1 month was also associated with a lower 1-year corrected age BSID-III score of receptive language(p=0.05) and fine motor development (p=0.03). Infant RBC-DHA did not ecrease significantly after delivery and was not associated with any of the developmental outcomes.Conclusion: Breast-milk LC-PUFA content was reflected in the RBC LC-PUFA status of the infant. Early RBC-AA status was associated with both early and long-term neurobehavioral development, but not in a consistent way.
AB - Background: The supply of long-chain polyunsaturated fatty acids (LC-PUFA) during pregnancy and early lactation has been shown to affect cognitive development in preterm infants, but the effect on early neurodevelopment of late-preterm infants has not yet been examined.Aim: To examine the fatty acid composition of late-preterm human milk and identify possible associations between infant LC-PUFA status and perinatal as well as 1-year neurobehavioral outcomes.Methods: Mother’s milk and erythrocytes (RBC) were sampled from 53 Danish late-preterm infants (33-36 weeks of gestation) 1 week and 1 month after delivery, and 3 months corrected age. Fatty acid composition was determinedby gas-liquid chromatography. Neurodevelopmental outcomes were assessed by the Nicu Network Neurobehavioral Scale (NNNS) at 1 week and 1 month and the Bayley Scales (BSID-III) at 1 year corrected age.Results: We found that breast-milk content of arachidonic acid (AA) and docosahexaenoic acid (DHA) was similar to reported fatty acid compositions of term human milk. Infant RBC-AA decreased from 1 week to 1 month of age andthe size of the decrease was associated with better NNNS-scores at 1 month, specifically on regulation (p=0.03). Infant RBC-AA at 1 month was also associated with a lower 1-year corrected age BSID-III score of receptive language(p=0.05) and fine motor development (p=0.03). Infant RBC-DHA did not ecrease significantly after delivery and was not associated with any of the developmental outcomes.Conclusion: Breast-milk LC-PUFA content was reflected in the RBC LC-PUFA status of the infant. Early RBC-AA status was associated with both early and long-term neurobehavioral development, but not in a consistent way.
U2 - 10.4172/2376-127x.1000160
DO - 10.4172/2376-127x.1000160
M3 - Journal article
VL - 2
JO - Journal of Pregnancy and Child Health
JF - Journal of Pregnancy and Child Health
SN - 2376-127X
IS - 3
M1 - 1000160
ER -
ID: 137786946