Leptin and bone mineral density: a cross-sectional study in obese and nonobese men
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Leptin and bone mineral density : a cross-sectional study in obese and nonobese men. / Morberg, Cathrine M.; Tetens, Inge; Black, Eva; Toubro, Søren; Sørensen, Thorkild I.A.; Pedersen, Oluf Borbye; Astrup, Arne.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 88, No. 12, 2003, p. 5795-5800.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Leptin and bone mineral density
T2 - a cross-sectional study in obese and nonobese men
AU - Morberg, Cathrine M.
AU - Tetens, Inge
AU - Black, Eva
AU - Toubro, Søren
AU - Sørensen, Thorkild I.A.
AU - Pedersen, Oluf Borbye
AU - Astrup, Arne
PY - 2003
Y1 - 2003
N2 - Leptin has been suggested to decrease bone mineral density (BMD). This observational analysis explored the relationship between serum leptin and BMD in 327 nonobese men (controls) (body mass index 26.1 +/- 3.7 kg/m(2), age 49.9 +/- 6.0 yr) and 285 juvenile obese men (body mass index 35.9 +/- 5.9 kg/m(2), age 47.5 +/- 5.1 yr). Whole-body dual-energy x-ray absorptiometry scan measured BMD, fat mass, and lean mass. Fasting serum leptin (nanograms per milliliter) was strongly associated with fat mass (kilograms) in both controls (r = 0.876; P <0.01) and juvenile obese (r = 0.838; P <0.001). An inverse relation between BMD adjusted for body weight and serum leptin emerged in both the control group (r = -0.186; P <0.01) and the juvenile obese group (r = -0.135; P <0.05). In a multiple linear regression, fat mass, lean body mass, and occupational physical activity were positively associated with BMD in the control group, whereas in the juvenile obese, only lean body mass was positively associated with BMD and smoking negatively associated with BMD. Our study supports that leptin is inversely associated with BMD and may play a direct role in the bone metabolism in nonobese and obese Danish males, but it also stresses the fact that the strong covariation between the examined variables is a shortcoming of the cross-sectional design.
AB - Leptin has been suggested to decrease bone mineral density (BMD). This observational analysis explored the relationship between serum leptin and BMD in 327 nonobese men (controls) (body mass index 26.1 +/- 3.7 kg/m(2), age 49.9 +/- 6.0 yr) and 285 juvenile obese men (body mass index 35.9 +/- 5.9 kg/m(2), age 47.5 +/- 5.1 yr). Whole-body dual-energy x-ray absorptiometry scan measured BMD, fat mass, and lean mass. Fasting serum leptin (nanograms per milliliter) was strongly associated with fat mass (kilograms) in both controls (r = 0.876; P <0.01) and juvenile obese (r = 0.838; P <0.001). An inverse relation between BMD adjusted for body weight and serum leptin emerged in both the control group (r = -0.186; P <0.01) and the juvenile obese group (r = -0.135; P <0.05). In a multiple linear regression, fat mass, lean body mass, and occupational physical activity were positively associated with BMD in the control group, whereas in the juvenile obese, only lean body mass was positively associated with BMD and smoking negatively associated with BMD. Our study supports that leptin is inversely associated with BMD and may play a direct role in the bone metabolism in nonobese and obese Danish males, but it also stresses the fact that the strong covariation between the examined variables is a shortcoming of the cross-sectional design.
KW - Adult
KW - Age of Onset
KW - Body Composition
KW - Bone Density
KW - Case-Control Studies
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Humans
KW - Leptin
KW - Linear Models
KW - Male
KW - Middle Aged
KW - Obesity
KW - Physical Exertion
KW - Smoking
U2 - 10.1210/jc.2003-030496
DO - 10.1210/jc.2003-030496
M3 - Journal article
C2 - 14671171
VL - 88
SP - 5795
EP - 5800
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 12
ER -
ID: 38457534