Induction of motor associative plasticity in the posterior parietal cortex-primary motor network
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Induction of motor associative plasticity in the posterior parietal cortex-primary motor network. / Chao, Chi-Chao; Karabanov, Anke Ninija; Paine, Rainer; de Campos, Ana Carolina; Kukke, Sahana N.; Wu, Tianxia; Wang, Han-Ming; Hallett, Mark.
In: Cerebral Cortex, Vol. 25, No. 2, 2015, p. 365-373.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Induction of motor associative plasticity in the posterior parietal cortex-primary motor network
AU - Chao, Chi-Chao
AU - Karabanov, Anke Ninija
AU - Paine, Rainer
AU - de Campos, Ana Carolina
AU - Kukke, Sahana N.
AU - Wu, Tianxia
AU - Wang, Han-Ming
AU - Hallett, Mark
N1 - CURIS 2015 NEXS 452
PY - 2015
Y1 - 2015
N2 - There is anatomical and functional connectivity between the primary motor cortex (M1) and posterior parietal cortex (PPC) that plays a role in sensorimotor integration. In this study, we applied corticocortical paired-associative stimuli to ipsilateral PPC and M1 (parietal ccPAS) in healthy right-handed subjects to test if this procedure could modulate M1 excitability and PPC–M1 connectivity. Onehundred and eighty paired transcranial magnetic stimuli to the PPC and M1 at an interstimulus interval (ISI) of 8 ms were delivered at 0.2 Hz. We found that parietal ccPAS in the left hemisphere increased the excitability of conditioned left M1 assessed by motor evoked potentials (MEPs) and the input–output curve. Motor behavior assessed by the Purdue pegboard task was unchanged comparedwith controls. At baseline, conditioning stimuli over the left PPC potentiated MEPs from left M1 when ISI was 8 ms. This interaction significantly attenuated at 60 min after left parietal ccPAS. Additional experiments showed that parietal ccPAS induced plasticity was timing-dependent, was absent if ISI was 100 ms, and could also be seen in the right hemisphere. Our results suggest that parietal ccPAS can modulate M1 excitability and PPC–M1 connectivity and is a newapproach to modify motor excitability and sensorimotor interaction.
AB - There is anatomical and functional connectivity between the primary motor cortex (M1) and posterior parietal cortex (PPC) that plays a role in sensorimotor integration. In this study, we applied corticocortical paired-associative stimuli to ipsilateral PPC and M1 (parietal ccPAS) in healthy right-handed subjects to test if this procedure could modulate M1 excitability and PPC–M1 connectivity. Onehundred and eighty paired transcranial magnetic stimuli to the PPC and M1 at an interstimulus interval (ISI) of 8 ms were delivered at 0.2 Hz. We found that parietal ccPAS in the left hemisphere increased the excitability of conditioned left M1 assessed by motor evoked potentials (MEPs) and the input–output curve. Motor behavior assessed by the Purdue pegboard task was unchanged comparedwith controls. At baseline, conditioning stimuli over the left PPC potentiated MEPs from left M1 when ISI was 8 ms. This interaction significantly attenuated at 60 min after left parietal ccPAS. Additional experiments showed that parietal ccPAS induced plasticity was timing-dependent, was absent if ISI was 100 ms, and could also be seen in the right hemisphere. Our results suggest that parietal ccPAS can modulate M1 excitability and PPC–M1 connectivity and is a newapproach to modify motor excitability and sensorimotor interaction.
KW - associative plasticity
KW - corticocortical paired-associative stimulation
KW - motor cortex
KW - parietal motor connectivity
KW - posterior parietal cortex
U2 - 10.1093/cercor/bht230
DO - 10.1093/cercor/bht230
M3 - Journal article
C2 - 23968834
VL - 25
SP - 365
EP - 373
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 2
ER -
ID: 162342930