Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
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Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. / Vogelezang, Suzanne; Bradfield, Jonathan P; Early Growth Genetics Consortium ; Ahluwalia, Tarun Veer Singh; Liu, Xueping; Schnurr, Theresia Maria; Frithioff-Bøjsøe, Christine; Bønnelykke, Klaus; Lind, Mads Vendelbo; Lauritzen, Lotte; Michaelsen, Kim F.; Lund, Morten Asp Vonsild; Melbye, Mads; Morgen, Camilla Schmidt; Pedersen, Oluf Borbye; Holm, Jens-Christian; Grarup, Niels; Hansen, Torben; Nohr, Ellen A; Bisgaard, Hans; Grant, Struan F A; Felix, Janine F; Jaddoe, Vincent W V.
In: BMC Medical Genomics, Vol. 15, 124, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
AU - Vogelezang, Suzanne
AU - Bradfield, Jonathan P
AU - Early Growth Genetics Consortium
AU - Ahluwalia, Tarun Veer Singh
AU - Liu, Xueping
AU - Schnurr, Theresia Maria
AU - Frithioff-Bøjsøe, Christine
AU - Bønnelykke, Klaus
AU - Lind, Mads Vendelbo
AU - Lauritzen, Lotte
AU - Michaelsen, Kim F.
AU - Lund, Morten Asp Vonsild
AU - Melbye, Mads
AU - Morgen, Camilla Schmidt
AU - Pedersen, Oluf Borbye
AU - Holm, Jens-Christian
AU - Grarup, Niels
AU - Hansen, Torben
AU - Nohr, Ellen A
AU - Bisgaard, Hans
AU - Grant, Struan F A
AU - Felix, Janine F
AU - Jaddoe, Vincent W V
N1 - © 2022. The Author(s).
PY - 2022
Y1 - 2022
N2 - Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
AB - Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
KW - Head circumference
KW - Infancy
KW - Genetic correlations
KW - Genome-Wide Association Study
U2 - 10.1186/s12920-022-01281-1
DO - 10.1186/s12920-022-01281-1
M3 - Journal article
C2 - 35659227
VL - 15
JO - BMC Medical Genomics
JF - BMC Medical Genomics
SN - 1755-8794
M1 - 124
ER -
ID: 309200587