Food-based concepts used for appetite manipulation in humans – A systematic review of systematic reviews with meta-analyses
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Food-based concepts used for appetite manipulation in humans – A systematic review of systematic reviews with meta-analyses. / Hansen, Thea Toft; Astrup, Arne; Sjödin, Anders.
In: Obesity Medicine, Vol. 22, 100322, 2021.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Food-based concepts used for appetite manipulation in humans – A systematic review of systematic reviews with meta-analyses
AU - Hansen, Thea Toft
AU - Astrup, Arne
AU - Sjödin, Anders
N1 - CURIS 2021 NEXS 060
PY - 2021
Y1 - 2021
N2 - Aims: Strategies to reduce appetite may provide tools to help people with obesity to manage their body weight. The aim of this systematic review was to summarize the existing systematic reviews with meta-analyses on specific food-based concepts’ potential effects on appetite. Methods: A systematic literature search in PubMed identified 141 reviews with 10 meeting the inclusion criteria. A thorough risk of bias assessment was performed based on the critical appraisal tool for systematic reviews, AMSTAR 2. Results: Based on the included reviews, the food-based concepts were divided into the following categories: Manipulations of macronutrient content (including fibers) (7 reviews/85 unique studies); Ketogenic diets (1 review/12 studies); Bioactive components (1 review/8 studies); Changes in food structures (1 review/16 studies). The dietary fiber polydextrose, dietary pulses, dairy products, ketogenic diets, the bioactive component capsaiconioids, and manipulation of food structure using vegetable oil formulation (Fabuless™/Olibra®), were found to have the potential to reduce appetite. Conclusion: Overall, these concepts resulted in rather moderate, but still potentially meaningful, reductions in appetite. Thereby, new food-based concepts may be effective tools to fill the “therapeutic gap” between traditional body weight management interventions and pharmaceutical or surgical approaches.
AB - Aims: Strategies to reduce appetite may provide tools to help people with obesity to manage their body weight. The aim of this systematic review was to summarize the existing systematic reviews with meta-analyses on specific food-based concepts’ potential effects on appetite. Methods: A systematic literature search in PubMed identified 141 reviews with 10 meeting the inclusion criteria. A thorough risk of bias assessment was performed based on the critical appraisal tool for systematic reviews, AMSTAR 2. Results: Based on the included reviews, the food-based concepts were divided into the following categories: Manipulations of macronutrient content (including fibers) (7 reviews/85 unique studies); Ketogenic diets (1 review/12 studies); Bioactive components (1 review/8 studies); Changes in food structures (1 review/16 studies). The dietary fiber polydextrose, dietary pulses, dairy products, ketogenic diets, the bioactive component capsaiconioids, and manipulation of food structure using vegetable oil formulation (Fabuless™/Olibra®), were found to have the potential to reduce appetite. Conclusion: Overall, these concepts resulted in rather moderate, but still potentially meaningful, reductions in appetite. Thereby, new food-based concepts may be effective tools to fill the “therapeutic gap” between traditional body weight management interventions and pharmaceutical or surgical approaches.
KW - Body weight management
KW - Hunger
KW - Motivation to eat
KW - Obesity
KW - Overweight
KW - Satiety
U2 - 10.1016/j.obmed.2021.100322
DO - 10.1016/j.obmed.2021.100322
M3 - Review
AN - SCOPUS:85099992047
VL - 22
JO - Obesity Medicine
JF - Obesity Medicine
SN - 2451-8476
M1 - 100322
ER -
ID: 256571475