Enhanced insulin sensitivity after acute exercise is not associated with changes in high-molecular weight adiponectin concentration in plasma
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Background and objective: The effect of exercise on the plasma concentration of high-molecular weight (HMW) adiponectin (i.e. the biologically active form of circulating adiponectin) and the possible role of HMW adiponectin in mediating the exercise-induced enhancement of insulin action are not known. The aim of this study was to evaluate the relationship between the post-exercise increase in insulin sensitivity and plasma HMW adiponectin concentration.
Design and methods: We measured total and HMW adiponectin concentrations in plasma using an ELISA kit, and insulin sensitivity using the updated homeostasis model assessment of insulin sensitivity (HOMA2-IS) score in the basal, overnight fasted state, once approximately 12 h after a single bout of moderate-intensity endurance exercise and once after an equivalent period of rest, in 27 healthy men and women (age: 29+/-1 years and body mass index: 24.7+/-0.8 kg/m(2)).
Results: The HOMA2-IS score was 18+/-7% greater after exercise than after rest (229+/-20 and 196+/-17 respectively; P=0.006), whereas the concentrations of total adiponectin (7.8+/-0.5 and 7.7+/-0.5 mg/l respectively; P=0.597) and HMW adiponectin (3.0+/-0.3 and 3.0+/-0.3 mg/l respectively; P=0.625) were not different. The exercise-induced change in HOMA2-IS score was not related to changes in total and HMW adiponectin concentrations (P>0.3).
Conclusions: Changes in HMW adiponectin concentration are not involved in the acute exercise-induced enhancement of insulin action.
Original language | English |
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Journal | European Journal of Endocrinology |
Volume | 162 |
Issue number | 1 |
Pages (from-to) | 61-66 |
Number of pages | 6 |
ISSN | 0804-4643 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |
- Adiponectin/blood, Adult, Blood Glucose/metabolism, Exercise/physiology, Female, Homeostasis/physiology, Humans, Insulin/blood, Insulin Resistance/physiology, Male, Time Factors
Research areas
ID: 290670949