Effect of β-glucan supplementation on acute postprandial changes in fatty acid profile of lymph and serum in pigs
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Effect of β-glucan supplementation on acute postprandial changes in fatty acid profile of lymph and serum in pigs. / Lærke, Helle Nygaard; Mikkelsen, Lasse Sommer; Jørgensen, Henry; Jensen, Søren Krogh.
In: International Journal of Molecular Sciences, Vol. 15, No. 8, 2014, p. 13881-13891.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of β-glucan supplementation on acute postprandial changes in fatty acid profile of lymph and serum in pigs
AU - Lærke, Helle Nygaard
AU - Mikkelsen, Lasse Sommer
AU - Jørgensen, Henry
AU - Jensen, Søren Krogh
N1 - (Ekstern)
PY - 2014
Y1 - 2014
N2 - Triglycerides are absorbed by the lymphatic system and have various functions in the body. It has been shown that some types of β-glucans have a positive effect on the systemic concentrations of cholesterol and lipid, presumably through interference with the absorption of lipid and/or reabsorption of bile acids. In the current study we investigated the acute effects of ingesting 2 g of β-glucan concentrates derived from barley β-(1→3)(1→4)-D-glucan or yeast β-(1→3)(1→6)-D-glucan on fatty acid content and composition in lymph and serum of 10 female pigs (initial weight 34.7±1.1 kg) fitted with a permanent catheter in the jejunal lymphatic trunk in a cross-over design. Lymph was collected continuously for 8 h followed by a spot sample taken 24 h after. A significant effect of time after feeding was observed for all fatty acids in serum and for 18:0, 18:2ω6 and 18:3ω3 in lymph, but a significant effect of β-glucan was only observed for 14:0 (p=0.049) and 22:6ω3 (p=0.048) in lymph and 18:0 (p=0.019) in serum. While the concentration of dietary fatty acids increased postprandially in lymph, the concentration of arachidonic and docahexanoic acid tended to decrease. Furthermore, there was a drop in concentration of all fatty acid in serum 1 h after the meal.
AB - Triglycerides are absorbed by the lymphatic system and have various functions in the body. It has been shown that some types of β-glucans have a positive effect on the systemic concentrations of cholesterol and lipid, presumably through interference with the absorption of lipid and/or reabsorption of bile acids. In the current study we investigated the acute effects of ingesting 2 g of β-glucan concentrates derived from barley β-(1→3)(1→4)-D-glucan or yeast β-(1→3)(1→6)-D-glucan on fatty acid content and composition in lymph and serum of 10 female pigs (initial weight 34.7±1.1 kg) fitted with a permanent catheter in the jejunal lymphatic trunk in a cross-over design. Lymph was collected continuously for 8 h followed by a spot sample taken 24 h after. A significant effect of time after feeding was observed for all fatty acids in serum and for 18:0, 18:2ω6 and 18:3ω3 in lymph, but a significant effect of β-glucan was only observed for 14:0 (p=0.049) and 22:6ω3 (p=0.048) in lymph and 18:0 (p=0.019) in serum. While the concentration of dietary fatty acids increased postprandially in lymph, the concentration of arachidonic and docahexanoic acid tended to decrease. Furthermore, there was a drop in concentration of all fatty acid in serum 1 h after the meal.
KW - Animals
KW - Dietary Supplements
KW - Fatty Acids/blood
KW - Female
KW - Lymph/metabolism
KW - Swine
KW - Time Factors
KW - beta-Glucans/pharmacology
U2 - 10.3390/ijms150813881
DO - 10.3390/ijms150813881
M3 - Journal article
C2 - 25116686
VL - 15
SP - 13881
EP - 13891
JO - International Journal of Molecular Sciences (CD-ROM)
JF - International Journal of Molecular Sciences (CD-ROM)
SN - 1424-6783
IS - 8
ER -
ID: 290678459