Brain on fire: Incentive salience, hedonic hot spots, dopamine, obesity, and other hunger games
Research output: Contribution to journal › Review › Research › peer-review
Standard
Brain on fire : Incentive salience, hedonic hot spots, dopamine, obesity, and other hunger games. / Cameron, Jameason D; Chaput, Jean-Philippe; Sjödin, Anders Mikael; Goldfield, Gary S.
In: Annual Review of Nutrition, Vol. 37, 2017, p. 183-205.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Brain on fire
T2 - Incentive salience, hedonic hot spots, dopamine, obesity, and other hunger games
AU - Cameron, Jameason D
AU - Chaput, Jean-Philippe
AU - Sjödin, Anders Mikael
AU - Goldfield, Gary S
N1 - CURIS 2017 NEXS 161
PY - 2017
Y1 - 2017
N2 - This review examines human feeding behavior in light of psychological motivational theory and highlights the importance of midbrain dopamine (DA). Prospective evidence of both reward surfeit and reward deficit pathways to increased body weight are evaluated, and we argue that it is more complex than an either/or scenario when examining DA's role in reward sensitivity, eating, and obesity. The Taq1A genotype is a common thread that ties the contrasting models of DA reward and obesity; this genotype related to striatal DA is not associated with obesity class per se but may nevertheless confer an increased risk of weight gain. We also critically examine the concept of so-called food addiction, and despite growing evidence, we argue that there is currently insufficient human data to warrant this diagnostic label. The surgical and pharmacological treatments of obesity are discussed, and evidence is presented for the selective use of DA-class drugs in obesity treatment. Expected final online publication date for the Annual Review of Nutrition Volume 37 is August 21, 2017. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
AB - This review examines human feeding behavior in light of psychological motivational theory and highlights the importance of midbrain dopamine (DA). Prospective evidence of both reward surfeit and reward deficit pathways to increased body weight are evaluated, and we argue that it is more complex than an either/or scenario when examining DA's role in reward sensitivity, eating, and obesity. The Taq1A genotype is a common thread that ties the contrasting models of DA reward and obesity; this genotype related to striatal DA is not associated with obesity class per se but may nevertheless confer an increased risk of weight gain. We also critically examine the concept of so-called food addiction, and despite growing evidence, we argue that there is currently insufficient human data to warrant this diagnostic label. The surgical and pharmacological treatments of obesity are discussed, and evidence is presented for the selective use of DA-class drugs in obesity treatment. Expected final online publication date for the Annual Review of Nutrition Volume 37 is August 21, 2017. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
KW - Energy intake
KW - Food reward
KW - Food addiction
KW - BMI
KW - fMRI
KW - Obesity surgery
KW - Liking
U2 - 10.1146/annurev-nutr-071816-064855
DO - 10.1146/annurev-nutr-071816-064855
M3 - Review
C2 - 28564556
VL - 37
SP - 183
EP - 205
JO - Annual Review of Nutrition
JF - Annual Review of Nutrition
SN - 0199-9885
ER -
ID: 179364004