Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss
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Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss. / Su, Xiong; Magkos, Faidon; Zhou, Dequan; Eagon, J Christopher; Fabbrini, Elisa; Okunade, Adewole L; Klein, Samuel.
In: Obesity, Vol. 23, No. 2, 2015, p. 329-334.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss
AU - Su, Xiong
AU - Magkos, Faidon
AU - Zhou, Dequan
AU - Eagon, J Christopher
AU - Fabbrini, Elisa
AU - Okunade, Adewole L
AU - Klein, Samuel
N1 - © 2014 The Obesity Society.
PY - 2015
Y1 - 2015
N2 - Objectives: An increase in circulating branched-chain amino acids (BCAA) is associated with insulin resistance. Adipose tissue is a potentially important site for BCAA metabolism. It was evaluated whether monomethyl branched-chain fatty acids (mmBCFA) in adipose tissue, which are likely derived from BCAA catabolism, are associated with insulin sensitivity.Methods: Insulin-stimulated glucose disposal was determined by using the hyperinsulinemic-euglycemic clamp procedure with stable isotope glucose tracer infusion in nine lean and nine obese subjects, and in a separate group of nine obese subjects before and 1 year after Roux-en-Y gastric bypass (RYGB) surgery (38% weight loss). Adipose tissue mmBCFA content was measured in tissue biopsies taken in the basal state.Results: Total adipose tissue mmBCFA content was ∼30% lower in obese than lean subjects (P = 0.02) and increased by ∼65% after weight loss in the RYGB group (P = 0.01). Adipose tissue mmBCFA content correlated positively with skeletal muscle insulin sensitivity (R2 =35%, P = 0.01, n = 18).Conclusions: These results demonstrate a novel association between adipose tissue mmBCFA content and obesity-related insulin resistance. Additional studies are needed to determine whether the association between adipose tissue mmBCFA and muscle insulin sensitivity is causal or a simple association.
AB - Objectives: An increase in circulating branched-chain amino acids (BCAA) is associated with insulin resistance. Adipose tissue is a potentially important site for BCAA metabolism. It was evaluated whether monomethyl branched-chain fatty acids (mmBCFA) in adipose tissue, which are likely derived from BCAA catabolism, are associated with insulin sensitivity.Methods: Insulin-stimulated glucose disposal was determined by using the hyperinsulinemic-euglycemic clamp procedure with stable isotope glucose tracer infusion in nine lean and nine obese subjects, and in a separate group of nine obese subjects before and 1 year after Roux-en-Y gastric bypass (RYGB) surgery (38% weight loss). Adipose tissue mmBCFA content was measured in tissue biopsies taken in the basal state.Results: Total adipose tissue mmBCFA content was ∼30% lower in obese than lean subjects (P = 0.02) and increased by ∼65% after weight loss in the RYGB group (P = 0.01). Adipose tissue mmBCFA content correlated positively with skeletal muscle insulin sensitivity (R2 =35%, P = 0.01, n = 18).Conclusions: These results demonstrate a novel association between adipose tissue mmBCFA content and obesity-related insulin resistance. Additional studies are needed to determine whether the association between adipose tissue mmBCFA and muscle insulin sensitivity is causal or a simple association.
KW - Adipose Tissue/metabolism
KW - Adult
KW - Cross-Sectional Studies
KW - Fatty Acids/metabolism
KW - Female
KW - Gastric Bypass
KW - Glucose Clamp Technique
KW - Humans
KW - Insulin/metabolism
KW - Insulin Resistance/physiology
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Obesity/metabolism
KW - Weight Loss/physiology
U2 - 10.1002/oby.20923
DO - 10.1002/oby.20923
M3 - Journal article
C2 - 25328153
VL - 23
SP - 329
EP - 334
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 2
ER -
ID: 289963282