Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: Protocol for a multicentre, cross-over, RCT in people with overweight/obesity - the SWEET Project
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Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: Protocol for a multicentre, cross-over, RCT in people with overweight/obesity - the SWEET Project. / Gibbons, Catherine; O'Hara, Beverley; O'Connor, Dominic; Hardman, Charlotte; Wilton, Moon; Harrold, Joanne A; Almiron-Roig, Eva; Navas-Carretero, Santiago; Hodgkins, Charo E; Nazare, Julie Anne; Alligier, Maud; Martínez, José Alfredo; Scott, Corey; Kjølbæk, Louise; Normand, Mie; Rannou, Cécile; Blaak, Ellen E; Feskens, Edith; Moshoyiannis, Hariklia; Raben, Anne; Halford, Jason C.G.; Beaulieu, Kristine; Finlayson, Graham.
In: BMJ Open, Vol. 12, No. 12, e063903, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: Protocol for a multicentre, cross-over, RCT in people with overweight/obesity - the SWEET Project
AU - Gibbons, Catherine
AU - O'Hara, Beverley
AU - O'Connor, Dominic
AU - Hardman, Charlotte
AU - Wilton, Moon
AU - Harrold, Joanne A
AU - Almiron-Roig, Eva
AU - Navas-Carretero, Santiago
AU - Hodgkins, Charo E
AU - Nazare, Julie Anne
AU - Alligier, Maud
AU - Martínez, José Alfredo
AU - Scott, Corey
AU - Kjølbæk, Louise
AU - Normand, Mie
AU - Rannou, Cécile
AU - Blaak, Ellen E
AU - Feskens, Edith
AU - Moshoyiannis, Hariklia
AU - Raben, Anne
AU - Halford, Jason C.G.
AU - Beaulieu, Kristine
AU - Finlayson, Graham
N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2022
Y1 - 2022
N2 - Introduction: Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes. Methods and analysis: A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&SE blends and no added sugar). Participants (body mass index 25-35 kg/m2; aged 18-60 years) will consume each formulation for 14 days. The primary endpoint is composite appetite score (hunger, inverse of fullness, desire to eat and prospective food consumption) over a 3-hour postprandial incremental area under the curve during clinical investigation days on days 1 and 14. Ethics and dissemination: The trial has been approved by national ethical committees and will be conducted in accordance with the Declaration of Helsinki. Results will be published in international peer-reviewed open-access scientific journals. Research data from the trial will be deposited in an open-access online research data archive. Trial registration number: NCT04633681.
AB - Introduction: Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes. Methods and analysis: A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&SE blends and no added sugar). Participants (body mass index 25-35 kg/m2; aged 18-60 years) will consume each formulation for 14 days. The primary endpoint is composite appetite score (hunger, inverse of fullness, desire to eat and prospective food consumption) over a 3-hour postprandial incremental area under the curve during clinical investigation days on days 1 and 14. Ethics and dissemination: The trial has been approved by national ethical committees and will be conducted in accordance with the Declaration of Helsinki. Results will be published in international peer-reviewed open-access scientific journals. Research data from the trial will be deposited in an open-access online research data archive. Trial registration number: NCT04633681.
KW - General endocrinology
KW - Nutrition & dietetics
KW - Protocols & guidelines
KW - Public health
KW - Sweeteners
KW - Sweetness enhancers
KW - Appetite
KW - Overweight
KW - Obesity
U2 - 10.1136/bmjopen-2022-063903
DO - 10.1136/bmjopen-2022-063903
M3 - Journal article
C2 - 36564114
AN - SCOPUS:85144635488
VL - 12
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 12
M1 - e063903
ER -
ID: 332046029