A standard calculation methodology for human doubly labeled water studies
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A standard calculation methodology for human doubly labeled water studies. / Speakman, John R; Yamada, Yosuke; Sagayama, Hiroyuki; Sjödin, Anders Mikael; the IAEA DLW database group.
In: Cell Reports Medicine, Vol. 2, No. 2, 100203, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A standard calculation methodology for human doubly labeled water studies
AU - Speakman, John R
AU - Yamada, Yosuke
AU - Sagayama, Hiroyuki
AU - Berman, Elena S F
AU - Ainslie, Philip N
AU - Andersen, Lene F
AU - Anderson, Liam J.
AU - Arab, Lenore
AU - Baddou, Issaad
AU - Bedu-Addo, Kweku
AU - Blaak, Ellen E.
AU - Blanc, Stephane
AU - Bonomi, Alberto G.
AU - Bouten, Carlijn V.C.
AU - Bovet, Pascal
AU - Buchowski, Maciej S.
AU - Butte, Nancy F.
AU - Camps, Stefan G.J.A.
AU - Close, Graeme L.
AU - Cooper, Jamie A.
AU - Creasy, Seth A.
AU - Das, Sai Krupa
AU - Cooper, Richard
AU - Dugas, Lara R.
AU - Ebbeling, Cara B.
AU - Ekelund, Ulf
AU - Entringer, Sonja
AU - Forrester, Terrence
AU - Fudge, Barry W.
AU - Goris, Annelies H.
AU - Gurven, Michael
AU - Hambly, Catherine
AU - El Hamdouchi, Asmaa
AU - Hoos, Marije B.
AU - Hu, Sumei
AU - Joonas, Noorjehan
AU - Joosen, Annemiek M.
AU - Katzmarzyk, Peter
AU - Kempen, Kitty P.
AU - Kimura, Misaka
AU - Kraus, William E.
AU - Kushner, Robert F.
AU - Lambert, Estelle V.
AU - Leonard, William R.
AU - Lessan, Nader
AU - Ludwig, David S.
AU - Martin, Corby K.
AU - Medin, Anine C
AU - Sjödin, Anders Mikael
AU - Wood, Brian M
AU - the IAEA DLW database group
N1 - CURIS 2021 NEXS 088
PY - 2021
Y1 - 2021
N2 - The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.
AB - The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO2 over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.
KW - Doubly labeled water
KW - Free-living
KW - Total energy expenditure
KW - Validation
UR - http://www.scopus.com/inward/record.url?scp=85100971338&partnerID=8YFLogxK
U2 - 10.1016/j.xcrm.2021.100203
DO - 10.1016/j.xcrm.2021.100203
M3 - Journal article
C2 - 33665639
AN - SCOPUS:85100971338
VL - 2
JO - Cell Reports Medicine
JF - Cell Reports Medicine
SN - 2666-3791
IS - 2
M1 - 100203
ER -
ID: 257744607