Trans, and n-3 polyunsaturated fatty acids and vascular function - a yin yang situation?

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Standard

Trans, and n-3 polyunsaturated fatty acids and vascular function - a yin yang situation? / Dyerberg, Jørn; Christensen, Jeppe H.; Eskesen, Dorte; Astrup, Arne; Stender, Steen.

I: Atherosclerosis - Supplements, Bind 7, Nr. 2, 2006, s. 33-35.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Dyerberg, J, Christensen, JH, Eskesen, D, Astrup, A & Stender, S 2006, 'Trans, and n-3 polyunsaturated fatty acids and vascular function - a yin yang situation?', Atherosclerosis - Supplements, bind 7, nr. 2, s. 33-35. https://doi.org/10.1016/j.atherosclerosissup.2006.04.017

APA

Dyerberg, J., Christensen, J. H., Eskesen, D., Astrup, A., & Stender, S. (2006). Trans, and n-3 polyunsaturated fatty acids and vascular function - a yin yang situation? Atherosclerosis - Supplements, 7(2), 33-35. https://doi.org/10.1016/j.atherosclerosissup.2006.04.017

Vancouver

Dyerberg J, Christensen JH, Eskesen D, Astrup A, Stender S. Trans, and n-3 polyunsaturated fatty acids and vascular function - a yin yang situation? Atherosclerosis - Supplements. 2006;7(2):33-35. https://doi.org/10.1016/j.atherosclerosissup.2006.04.017

Author

Dyerberg, Jørn ; Christensen, Jeppe H. ; Eskesen, Dorte ; Astrup, Arne ; Stender, Steen. / Trans, and n-3 polyunsaturated fatty acids and vascular function - a yin yang situation?. I: Atherosclerosis - Supplements. 2006 ; Bind 7, Nr. 2. s. 33-35.

Bibtex

@article{b4032280a1c011ddb6ae000ea68e967b,
title = "Trans, and n-3 polyunsaturated fatty acids and vascular function - a yin yang situation?",
abstract = "Trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (n-3 PUFA) have opposite effects on several biological functions. We report a study on the effects on risk markers for cardiovascular disease. Eighty-seven healthy males were randomly assigned to 8 weeks of daily intake of either 20 g of industrially produced TFA (IP-TFA), 4 g n-3 PUFA, or control fat, incorporated in bakery products as part of the daily food.High-density lipoprotein cholesterol decreased in the TFA-group, triglycerides and mean arterial blood pressure decreased in the n-3 group. Heart rate variability (HRV), arterial dilatory capacity, flow mediated vasodilation, compliance, and distensibility were unchanged.Post hoc, we did a subgroup analysis of the results from the subjects with normal initial HRV. In these, 24-h heart rate (HR) was significantly increased by approximately three beats/min in the TFA group, with a decrease of the same magnitude in the n-3 group. A high HR is associated to an increased mortality and vice versa.Our results thus support the notion that IP-TFA and n-3 PUFA affect risk for cardiovascular mortality via mechanisms not only related to changes in plasma concentrations of lipids and lipoproteins.",
author = "J{\o}rn Dyerberg and Christensen, {Jeppe H.} and Dorte Eskesen and Arne Astrup and Steen Stender",
year = "2006",
doi = "10.1016/j.atherosclerosissup.2006.04.017",
language = "English",
volume = "7",
pages = "33--35",
journal = "Journal of atherosclerosis research",
issn = "1567-5688",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Trans, and n-3 polyunsaturated fatty acids and vascular function - a yin yang situation?

AU - Dyerberg, Jørn

AU - Christensen, Jeppe H.

AU - Eskesen, Dorte

AU - Astrup, Arne

AU - Stender, Steen

PY - 2006

Y1 - 2006

N2 - Trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (n-3 PUFA) have opposite effects on several biological functions. We report a study on the effects on risk markers for cardiovascular disease. Eighty-seven healthy males were randomly assigned to 8 weeks of daily intake of either 20 g of industrially produced TFA (IP-TFA), 4 g n-3 PUFA, or control fat, incorporated in bakery products as part of the daily food.High-density lipoprotein cholesterol decreased in the TFA-group, triglycerides and mean arterial blood pressure decreased in the n-3 group. Heart rate variability (HRV), arterial dilatory capacity, flow mediated vasodilation, compliance, and distensibility were unchanged.Post hoc, we did a subgroup analysis of the results from the subjects with normal initial HRV. In these, 24-h heart rate (HR) was significantly increased by approximately three beats/min in the TFA group, with a decrease of the same magnitude in the n-3 group. A high HR is associated to an increased mortality and vice versa.Our results thus support the notion that IP-TFA and n-3 PUFA affect risk for cardiovascular mortality via mechanisms not only related to changes in plasma concentrations of lipids and lipoproteins.

AB - Trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (n-3 PUFA) have opposite effects on several biological functions. We report a study on the effects on risk markers for cardiovascular disease. Eighty-seven healthy males were randomly assigned to 8 weeks of daily intake of either 20 g of industrially produced TFA (IP-TFA), 4 g n-3 PUFA, or control fat, incorporated in bakery products as part of the daily food.High-density lipoprotein cholesterol decreased in the TFA-group, triglycerides and mean arterial blood pressure decreased in the n-3 group. Heart rate variability (HRV), arterial dilatory capacity, flow mediated vasodilation, compliance, and distensibility were unchanged.Post hoc, we did a subgroup analysis of the results from the subjects with normal initial HRV. In these, 24-h heart rate (HR) was significantly increased by approximately three beats/min in the TFA group, with a decrease of the same magnitude in the n-3 group. A high HR is associated to an increased mortality and vice versa.Our results thus support the notion that IP-TFA and n-3 PUFA affect risk for cardiovascular mortality via mechanisms not only related to changes in plasma concentrations of lipids and lipoproteins.

U2 - 10.1016/j.atherosclerosissup.2006.04.017

DO - 10.1016/j.atherosclerosissup.2006.04.017

M3 - Journal article

C2 - 16713391

VL - 7

SP - 33

EP - 35

JO - Journal of atherosclerosis research

JF - Journal of atherosclerosis research

SN - 1567-5688

IS - 2

ER -

ID: 8019896