The hyperaemic response to passive leg movement is dependent on nitric oxide: a new tool to evaluate endothelial nitric oxide function

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Standard

The hyperaemic response to passive leg movement is dependent on nitric oxide : a new tool to evaluate endothelial nitric oxide function. / Mortensen, Stefan Peter; Askew, Christopher D; Walker, Meegan; Nyberg, Michael Permin; Hellsten, Ylva.

I: Journal of Physiology, Bind 590, Nr. 17, 2012, s. 4391-4400.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mortensen, SP, Askew, CD, Walker, M, Nyberg, MP & Hellsten, Y 2012, 'The hyperaemic response to passive leg movement is dependent on nitric oxide: a new tool to evaluate endothelial nitric oxide function', Journal of Physiology, bind 590, nr. 17, s. 4391-4400. https://doi.org/10.1113/jphysiol.2012.235952

APA

Mortensen, S. P., Askew, C. D., Walker, M., Nyberg, M. P., & Hellsten, Y. (2012). The hyperaemic response to passive leg movement is dependent on nitric oxide: a new tool to evaluate endothelial nitric oxide function. Journal of Physiology, 590(17), 4391-4400. https://doi.org/10.1113/jphysiol.2012.235952

Vancouver

Mortensen SP, Askew CD, Walker M, Nyberg MP, Hellsten Y. The hyperaemic response to passive leg movement is dependent on nitric oxide: a new tool to evaluate endothelial nitric oxide function. Journal of Physiology. 2012;590(17):4391-4400. https://doi.org/10.1113/jphysiol.2012.235952

Author

Mortensen, Stefan Peter ; Askew, Christopher D ; Walker, Meegan ; Nyberg, Michael Permin ; Hellsten, Ylva. / The hyperaemic response to passive leg movement is dependent on nitric oxide : a new tool to evaluate endothelial nitric oxide function. I: Journal of Physiology. 2012 ; Bind 590, Nr. 17. s. 4391-4400.

Bibtex

@article{b35971439a6a44acbbd2c9caeb8f4ec8,
title = "The hyperaemic response to passive leg movement is dependent on nitric oxide: a new tool to evaluate endothelial nitric oxide function",
abstract = "Key points Passive leg movement is associated with a ~3-fold increase in blood flow to the leg, but the underlying mechanisms remain unknown. Passive leg movement increased venous levels of metabolites of nitric oxide (NO) in young subjects, whereas they remained unaltered in the muscle interstitial space. Inhibition of NO synthesis lowered the vasodilatory response to passive leg movement by ~90%. The increase in leg blood flow was lower in elderly subjects compared to young subjects and leg blood flow did not increase when passive leg movement was performed by elderly with peripheral artery disease. The results suggest that the hyperaemia induced by passive leg movement is NO dependent. The hyperaemic response to passive leg movement and to ACh was also assessed in elderly subjects and patients with peripheral artery disease.",
author = "Mortensen, {Stefan Peter} and Askew, {Christopher D} and Meegan Walker and Nyberg, {Michael Permin} and Ylva Hellsten",
note = "CURIS 2012 5200 131",
year = "2012",
doi = "10.1113/jphysiol.2012.235952",
language = "English",
volume = "590",
pages = "4391--4400",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "17",

}

RIS

TY - JOUR

T1 - The hyperaemic response to passive leg movement is dependent on nitric oxide

T2 - a new tool to evaluate endothelial nitric oxide function

AU - Mortensen, Stefan Peter

AU - Askew, Christopher D

AU - Walker, Meegan

AU - Nyberg, Michael Permin

AU - Hellsten, Ylva

N1 - CURIS 2012 5200 131

PY - 2012

Y1 - 2012

N2 - Key points Passive leg movement is associated with a ~3-fold increase in blood flow to the leg, but the underlying mechanisms remain unknown. Passive leg movement increased venous levels of metabolites of nitric oxide (NO) in young subjects, whereas they remained unaltered in the muscle interstitial space. Inhibition of NO synthesis lowered the vasodilatory response to passive leg movement by ~90%. The increase in leg blood flow was lower in elderly subjects compared to young subjects and leg blood flow did not increase when passive leg movement was performed by elderly with peripheral artery disease. The results suggest that the hyperaemia induced by passive leg movement is NO dependent. The hyperaemic response to passive leg movement and to ACh was also assessed in elderly subjects and patients with peripheral artery disease.

AB - Key points Passive leg movement is associated with a ~3-fold increase in blood flow to the leg, but the underlying mechanisms remain unknown. Passive leg movement increased venous levels of metabolites of nitric oxide (NO) in young subjects, whereas they remained unaltered in the muscle interstitial space. Inhibition of NO synthesis lowered the vasodilatory response to passive leg movement by ~90%. The increase in leg blood flow was lower in elderly subjects compared to young subjects and leg blood flow did not increase when passive leg movement was performed by elderly with peripheral artery disease. The results suggest that the hyperaemia induced by passive leg movement is NO dependent. The hyperaemic response to passive leg movement and to ACh was also assessed in elderly subjects and patients with peripheral artery disease.

U2 - 10.1113/jphysiol.2012.235952

DO - 10.1113/jphysiol.2012.235952

M3 - Journal article

C2 - 22733658

VL - 590

SP - 4391

EP - 4400

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 17

ER -

ID: 41054090