TY - JOUR

T1 - The effect of nutritional supplementation on quality of life in people living with HIV

T2 - a randomized controlled trial

AU - Tesfaye Woldeyohannes, Markos

AU - Kæstel, Pernille

AU - Olsen, Mette Frahm

AU - Girma, Tsinuel

AU - Yilma, Daniel

AU - Abdissa, Alemseged

AU - Ritz, Christian

AU - Michaelsen, Kim F.

AU - Hanlon, Charlotte

AU - Friis, Henrik

N1 - CURIS 2016 NEXS 138

PY - 2016

Y1 - 2016

N2 - OBJECTIVE: To determine the effects of lipid-based nutrient supplements (LNS) on the quality of life of people living with HIV (PLHIV) during the first 3 months of antiretroviral treatment (ART), and to investigate the effects of timing of supplementation by comparing with supplementation during the subsequent 3 months.METHODS: Randomized controlled trial in three ART clinics within public health facilities in Jimma, Ethiopia. Participants were PLHIV eligible to start ART with body mass index >17kg/m(2) and given daily supplements of 200 grams of LNS containing whey or soy either during the first 3 months or the subsequent months of ART. The outcome was measured in terms of total quality of life scores on the adapted version of the WHOQOL-HIV-BREF assessed at baseline, 3 and 6 months.RESULTS: Of the 282 participants, 186 (66.0%) were women. The mean age (standard deviation SD) was 32.8 (±9.0) years, and the mean (SD) total quality of life score was 82.0 (±14.8) at baseline assessment. At 3 months, participants who received LNS showed better quality of life than those who only received ART without LNS [β=6.2, 95% confidence interval: 2.9: 9.6]. At 6 months, there was no difference in total quality of life score between the early and delayed supplementation groups [β=3.0, 95% confidence interval: -0.4: 6.4]. However, the early supplementation group showed higher scores on the social and spirituality domains than the delayed group.CONCLUSIONS: LNS given during the first 4 months of ART improves the quality of life of PLHIV. This article is protected by copyright. All rights reserved.

AB - OBJECTIVE: To determine the effects of lipid-based nutrient supplements (LNS) on the quality of life of people living with HIV (PLHIV) during the first 3 months of antiretroviral treatment (ART), and to investigate the effects of timing of supplementation by comparing with supplementation during the subsequent 3 months.METHODS: Randomized controlled trial in three ART clinics within public health facilities in Jimma, Ethiopia. Participants were PLHIV eligible to start ART with body mass index >17kg/m(2) and given daily supplements of 200 grams of LNS containing whey or soy either during the first 3 months or the subsequent months of ART. The outcome was measured in terms of total quality of life scores on the adapted version of the WHOQOL-HIV-BREF assessed at baseline, 3 and 6 months.RESULTS: Of the 282 participants, 186 (66.0%) were women. The mean age (standard deviation SD) was 32.8 (±9.0) years, and the mean (SD) total quality of life score was 82.0 (±14.8) at baseline assessment. At 3 months, participants who received LNS showed better quality of life than those who only received ART without LNS [β=6.2, 95% confidence interval: 2.9: 9.6]. At 6 months, there was no difference in total quality of life score between the early and delayed supplementation groups [β=3.0, 95% confidence interval: -0.4: 6.4]. However, the early supplementation group showed higher scores on the social and spirituality domains than the delayed group.CONCLUSIONS: LNS given during the first 4 months of ART improves the quality of life of PLHIV. This article is protected by copyright. All rights reserved.

U2 - 10.1111/tmi.12705

DO - 10.1111/tmi.12705

M3 - Journal article

C2 - 27115126

VL - 21

SP - 735

EP - 742

JO - Tropical Medicine & International Health

JF - Tropical Medicine & International Health

SN - 1360-2276

IS - 6

ER -