First-pass metabolism of ethanol in human beings: Effect of intravenous infusion of fructose
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First-pass metabolism of ethanol in human beings : Effect of intravenous infusion of fructose. / Parlesak, Alexandr; Billinger, Michael Hans Ulrich; Schäfer, Christian; Wehner, Heinz Dieter; Bode, Christiane; Bode, Johann Christian.
I: Alcohol, Bind 34, Nr. 2-3, 2004, s. 121-125.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - First-pass metabolism of ethanol in human beings
T2 - Effect of intravenous infusion of fructose
AU - Parlesak, Alexandr
AU - Billinger, Michael Hans Ulrich
AU - Schäfer, Christian
AU - Wehner, Heinz Dieter
AU - Bode, Christiane
AU - Bode, Johann Christian
N1 - (Ekstern) Funding Information: We are indebted to Dr. David G. Levitt for his generous support in the calculation of the pharmacokinetic values of ethanol catabolism with PKQuest. The study was generously supported by the Robert-Bosch-Foundation and by Deutsche Krebshilfe (70-1881-Bo 1).
PY - 2004
Y1 - 2004
N2 - Intravenous infusion of fructose has been shown to enhance reduced form of nicotinamide adenine dinucleotide reoxidation and, thereby, to enhance the metabolism of ethanol. In the current study, the effect of fructose infusion on first-pass metabolism of ethanol was studied in human volunteers. A significantly higher first-pass metabolism of ethanol was obtained after administration of fructose in comparison with findings for control experiments with an equimolar dose of glucose. Because fructose is metabolized predominantly in the liver and can be presumed to have virtually no effects in the stomach, results of the current study support the assumption that only a negligible part of first-pass metabolism of ethanol occurs in the stomach.
AB - Intravenous infusion of fructose has been shown to enhance reduced form of nicotinamide adenine dinucleotide reoxidation and, thereby, to enhance the metabolism of ethanol. In the current study, the effect of fructose infusion on first-pass metabolism of ethanol was studied in human volunteers. A significantly higher first-pass metabolism of ethanol was obtained after administration of fructose in comparison with findings for control experiments with an equimolar dose of glucose. Because fructose is metabolized predominantly in the liver and can be presumed to have virtually no effects in the stomach, results of the current study support the assumption that only a negligible part of first-pass metabolism of ethanol occurs in the stomach.
KW - Alcohol
KW - Ethanol
KW - First-pass metabolism
KW - Fructose
KW - Gastric
KW - Liver
U2 - 10.1016/j.alcohol.2004.06.009
DO - 10.1016/j.alcohol.2004.06.009
M3 - Journal article
C2 - 15902905
AN - SCOPUS:14344264562
VL - 34
SP - 121
EP - 125
JO - Alcohol
JF - Alcohol
SN - 0741-8329
IS - 2-3
ER -
ID: 306558359