Effect of angiotensin-converting enzyme inhibition on cardiovascular adaptation to exercise training
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Effect of angiotensin-converting enzyme inhibition on cardiovascular adaptation to exercise training. / Sjúrðarson, Tórur; Bejder, Jacob; Breenfeldt Andersen, Andreas; Bonne, Thomas; Kyhl, Kasper; Róin, Tóra; Patursson, Poula; Oddmarsdóttir Gregersen, Noomi; Skoradal, May-Britt; Schliemann, Michael; Lindegaard, Malte; Weihe, Pál; Mohr, Magni; Nordsborg, Nikolai Baastrup.
I: Physiological Reports, Bind 10, Nr. 13, e15382, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effect of angiotensin-converting enzyme inhibition on cardiovascular adaptation to exercise training
AU - Sjúrðarson, Tórur
AU - Bejder, Jacob
AU - Breenfeldt Andersen, Andreas
AU - Bonne, Thomas
AU - Kyhl, Kasper
AU - Róin, Tóra
AU - Patursson, Poula
AU - Oddmarsdóttir Gregersen, Noomi
AU - Skoradal, May-Britt
AU - Schliemann, Michael
AU - Lindegaard, Malte
AU - Weihe, Pál
AU - Mohr, Magni
AU - Nordsborg, Nikolai Baastrup
N1 - © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
PY - 2022
Y1 - 2022
N2 - Angiotensin-converting enzyme (ACE) activity may be one determinant of adaptability to exercise training, but well-controlled studies in humans without confounding conditions are lacking. Thus, the purpose of the present study was to investigate whether ACE inhibition affects cardiovascular adaptations to exercise training in healthy humans. Healthy participants of both genders (40 ± 7 years) completed a randomized, double-blind, placebo-controlled trial. Eight weeks of exercise training combined with placebo (PLA, n = 25) or ACE inhibitor (ACEi, n = 23) treatment was carried out. Before and after the intervention, cardiovascular characteristics were investigated. Mean arterial blood pressure was reduced (p < 0.001) by -5.5 [-8.4; -2.6] mmHg in ACEi , whereas the 0.7 [-2.0; 3.5] mmHg fluctuation in PLA was non-significant. Maximal oxygen uptake increased (p < 0.001) irrespective of ACE inhibitor treatment by 13 [8; 17] % in ACEi and 13 [9; 17] % in PLA. In addition, skeletal muscle endurance increased (p < 0.001) to a similar extent in both groups, with magnitudes of 82 [55; 113] % in ACEi and 74 [48; 105] % in PLA. In contrast, left atrial volume decreased (p < 0.05) by -9 [-16; -2] % in ACEi , but increased (p < 0.01) by 14 [5; 23] % in PLA. Total hemoglobin mass was reduced (p < 0.01) by -3 [-6; -1] % in ACEi , while a non-significant numeric increase of 2 [-0.4; 4] % existed in PLA. The lean mass remained constant in ACEi but increased (p < 0.001) by 3 [2; 4] % in PLA. In healthy middle-aged adults, 8 weeks of high-intensity exercise training increases maximal oxygen uptake and skeletal muscle endurance irrespective of ACE inhibitor treatment. However, ACE inhibitor treatment counteracts exercise training-induced increases in lean mass and left atrial volume. ACE inhibitor treatment compromises total hemoglobin mass.
AB - Angiotensin-converting enzyme (ACE) activity may be one determinant of adaptability to exercise training, but well-controlled studies in humans without confounding conditions are lacking. Thus, the purpose of the present study was to investigate whether ACE inhibition affects cardiovascular adaptations to exercise training in healthy humans. Healthy participants of both genders (40 ± 7 years) completed a randomized, double-blind, placebo-controlled trial. Eight weeks of exercise training combined with placebo (PLA, n = 25) or ACE inhibitor (ACEi, n = 23) treatment was carried out. Before and after the intervention, cardiovascular characteristics were investigated. Mean arterial blood pressure was reduced (p < 0.001) by -5.5 [-8.4; -2.6] mmHg in ACEi , whereas the 0.7 [-2.0; 3.5] mmHg fluctuation in PLA was non-significant. Maximal oxygen uptake increased (p < 0.001) irrespective of ACE inhibitor treatment by 13 [8; 17] % in ACEi and 13 [9; 17] % in PLA. In addition, skeletal muscle endurance increased (p < 0.001) to a similar extent in both groups, with magnitudes of 82 [55; 113] % in ACEi and 74 [48; 105] % in PLA. In contrast, left atrial volume decreased (p < 0.05) by -9 [-16; -2] % in ACEi , but increased (p < 0.01) by 14 [5; 23] % in PLA. Total hemoglobin mass was reduced (p < 0.01) by -3 [-6; -1] % in ACEi , while a non-significant numeric increase of 2 [-0.4; 4] % existed in PLA. The lean mass remained constant in ACEi but increased (p < 0.001) by 3 [2; 4] % in PLA. In healthy middle-aged adults, 8 weeks of high-intensity exercise training increases maximal oxygen uptake and skeletal muscle endurance irrespective of ACE inhibitor treatment. However, ACE inhibitor treatment counteracts exercise training-induced increases in lean mass and left atrial volume. ACE inhibitor treatment compromises total hemoglobin mass.
KW - Adult
KW - Angiotensin-Converting Enzyme Inhibitors (administration & dosage)
KW - Cardiovascular health
KW - Hypertension
KW - Exercise
KW - Female
KW - Hemoglobins
KW - Humans
KW - Male
KW - Middle Aged
KW - Oxygen
U2 - 10.14814/phy2.15382
DO - 10.14814/phy2.15382
M3 - Journal article
C2 - 35822425
VL - 10
JO - Physiological Reports
JF - Physiological Reports
SN - 2051-817X
IS - 13
M1 - e15382
ER -
ID: 315172882