TY - JOUR

T1 - Beneficial role of antioxidants on clinical outcomes and erythrocyte antioxidant parameters in rheumatoid arthritis patients

AU - Jalili, Mahsa

AU - Kolahi, Sousan

AU - Aref-Hosseini, Seyed Rafi

AU - Mamegani, Mehrangiz Ebrahimi

AU - Hekmatdoost, Azita

N1 - (Ekstern)

PY - 2014

Y1 - 2014

N2 - Background: This study aims to investigate the effect of antioxidants supplement on clinical outcomes and antioxidant parameters in rheumatoid arthritis (RA). Methods: The pre-post study was conducted on 40 female patients with RA in 12 weeks that taken daily one "Selenplus" capsule contained 50 μg selenium, 8 mg zinc, 400 μg vitamin A, 125 mg vitamin C, and 40 mg vitamin E. About 5 mL venous blood sample was taken from all participants and disease activity score (DAS) was determined by DAS-28 formula and high-sensitive C-reactive protein (hs-CRP). Glutathione peroxidase (GPX) and superoxide dismutase (SOD) were measured by spectrophotometric kit and catalase (CAT) was measured by Abei method. Total antioxidant capacity (TAC) was determined by spectrophotometric kit. Distribution of the variables was assessed using histogram with normal curve as well as Kolmogorov-Smirnov test and data were analyzed with paired t-test for differences between pre-post data using SPSS software version 13.5. Results: Out of 40 patients, 39 completed the study. DAS-28 score and hs-CRP have changed (P < 0.01 for both), while the number of swollen and painful joints did not reduce significantly. TAC, GPX, SOD, and CAT increased significantly (P < 0.01 for all variables). Conclusions: Our findings showed that antioxidants may improve disease activity significantly, but it did not affect the number of painful and swollen joints and increased erythrocyte antioxidant levels. Antioxidants may be useful for controlling of clinical outcomes and oxidative stress in RA.

AB - Background: This study aims to investigate the effect of antioxidants supplement on clinical outcomes and antioxidant parameters in rheumatoid arthritis (RA). Methods: The pre-post study was conducted on 40 female patients with RA in 12 weeks that taken daily one "Selenplus" capsule contained 50 μg selenium, 8 mg zinc, 400 μg vitamin A, 125 mg vitamin C, and 40 mg vitamin E. About 5 mL venous blood sample was taken from all participants and disease activity score (DAS) was determined by DAS-28 formula and high-sensitive C-reactive protein (hs-CRP). Glutathione peroxidase (GPX) and superoxide dismutase (SOD) were measured by spectrophotometric kit and catalase (CAT) was measured by Abei method. Total antioxidant capacity (TAC) was determined by spectrophotometric kit. Distribution of the variables was assessed using histogram with normal curve as well as Kolmogorov-Smirnov test and data were analyzed with paired t-test for differences between pre-post data using SPSS software version 13.5. Results: Out of 40 patients, 39 completed the study. DAS-28 score and hs-CRP have changed (P < 0.01 for both), while the number of swollen and painful joints did not reduce significantly. TAC, GPX, SOD, and CAT increased significantly (P < 0.01 for all variables). Conclusions: Our findings showed that antioxidants may improve disease activity significantly, but it did not affect the number of painful and swollen joints and increased erythrocyte antioxidant levels. Antioxidants may be useful for controlling of clinical outcomes and oxidative stress in RA.

KW - Antioxidants

KW - Dietary supplements

KW - Nutrition

KW - Oxidative stress

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=84904198667&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:84904198667

VL - 5

SP - 835

EP - 840

JO - International Journal of Preventive Medicine

JF - International Journal of Preventive Medicine

SN - 2008-7802

IS - 7

ER -